Involvement of glutamate and cytokine pathways on antinociceptive effect of Pfaffia glomerata in mice

Freitas, Cristina Setim; Baggio, Cristiane Hatsuko; Twardowschy, André; Santos, Ana Cristina dos; Mayer, Bárbara; Luiz, Ana Paula; Santos, Cid Aimbiré de Moraes; Marques, Maria Consuelo Andrade; Santos, Adair Roberto Soares

doi:10.1016/j.jep.2009.01.033

Cited by 13 publications

(7 citation statements)

References 33 publications

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“…Studies of molecules with antinociceptive action, both peripheral and central, demonstrated an interaction with mechanisms dependent on glutamate and Transient Receptor Potential (TRP) receptors . It is well established that various forms of glutamatergic neurotransmission contribute to the development and/or maintenance of hyperalgesia.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the anti‐inflammatory and antinociceptive effects of myrtenol, a plant‐derived monoterpene alcohol, in mice

Silva

Salvadori

Sousa

et al. 2014

Flavour & Fragrance J

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Inflammation is characterized by vasodilatation, increase of blood flow and vascular permeability, migration of leucocytes to the inflammatory site, and production of cytokines. The aim of this study was evaluate the anti‐inflammatory and antinociceptive effects of (−)‐myrtenol, a plant‐derived monoterpene alcohol, in mice and its possible mechanisms. Myrtenol was used in classical models of inflammation (paw oedema induced by different agents, carrageenan‐induced peritonitis, myeloperoxidase levels and cytokine measurement) and nociception (acetic acid‐induced writhing, hot‐plate test, and paw licking induced by formalin, glutamate, and capsaicin). Pretreatment with myrtenol effectively inhibited paw oedema induced by carrageenan, compound 48/80, histamine, serotonin and prostaglandin E2. Myrtenol also reduced the cell counts, myeloperoxidase activity and cytokine levels (interleukin 1β, but not tumour necrosis factor‐α) of the peritoneal cavity induced by carrageenan. In addition, myrtenol inhibited acetic acid‐induced writhing, did not significantly prolong the latency time in the hot‐plate test, decreased licking time caused by an intraplantar injection of formalin (only in the second phase), glutamate and capsaicin. Myrtenol reduces the inflammatory response and nociception in mice due to the inhibition of the release of inflammatory mediators, cell migration and also to the signalling pathway of receptors involved in the transmission of pain. Copyright © 2014 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the anti‐inflammatory and antinociceptive effects of myrtenol, a plant‐derived monoterpene alcohol, in mice

Silva

Salvadori

Sousa

et al. 2014

Flavour & Fragrance J

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“…This indicates that eugenol affects inflammatory pain. The cytokines released during an inflammatory response, such as TNF‐α, IL‐1β, and IFN‐γ, are capable of inducing nociceptive behavior when injected in the absence of peripheral nociceptive stimulation . In the central nervous system, TNF‐α is upregulated during peripheral inflammation, and it can inhibit the uptake of glutamate into astrocytes, therefore increasing its synaptic availability and transmission .…”

Section: Discussionmentioning

confidence: 99%

Eugenol reduces acute pain in mice by modulating the glutamatergic and tumor necrosis factor alpha (TNF‐α) pathways

Bó

Luiz

Martins

et al. 2012

Fundamemntal Clinical Pharma

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Eugenol is utilized together with zinc oxide in odontological clinical for the cementation of temporary prostheses and the temporary restoration of teeth and cavities. This work explored the antinociceptive effects of the eugenol in different models of acute pain in mice and investigated its possible modulation of the inhibitory (opioid) and excitatory (glutamatergic and pro-inflammatory cytokines) pathways of nociceptive signaling. The administration of eugenol (3-300 mg/kg, p.o., 60 min or i.p., 30 min) inhibited 82 ± 10% and 90 ± 6% of the acetic acid-induced nociception, with ID₅₀ values of 51.3 and 50.2 mg/kg, respectively. In the glutamate test, eugenol (0.3-100 mg/kg, i.p.) reduced the response behavior by 62 ± 5% with an ID₅₀ of 5.6 mg/kg. In addition, the antinociceptive effect of eugenol (10 mg/kg, i.p.) in the glutamate test was prevented by the i.p. treatment for mice with naloxone. The pretreatment of mice with eugenol (10 mg/kg, i.p.) was able to inhibit the nociception induced by the intrathecal (i.t.) injection of glutamate (37 ± 9%), kainic (acid kainite) (41 ± 12%), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) (55 ± 5%), and substance P (SP) (39 ± 8%). Furthermore, eugenol (10 mg/kg, i.p.) also inhibited biting induced by tumor necrosis factor alpha (TNF-α, 65 ± 8%). These results extend our current knowledge of eugenol and confirm that it promotes significant antinociception against different mouse models of acute pain. The mechanism of action appears to involve the modulation of the opioid system and glutamatergic receptors (i.e., kainate and AMPA), and the inhibition of TNF-α. Thus, eugenol could represent an important compound in the treatment for acute pain.

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“…Mice were observed individually for 15 min following an injection of glutamate and the amount of time spent licking the injected paw was recorded using a chronometer. Morphine (2.5 mg/kg, subcutaneously), administered 30 min before the test, was used as a positive control (Freitas et al, 2009).…”

Section: Glutamate-induced Nociceptionmentioning

confidence: 99%

Bis(phenylimidazoselenazolyl) diselenide

Chagas¹,

Bortolatto²,

Wilhelm³

et al. 2013

Behavioural Pharmacology

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The present study examined the effect of peroral administration of bis(phenylimidazoselenazolyl) diselenide (BPIS) in thermal and chemical models of pain in mice. The involvement of the opioid system in the BPIS antinociceptive effect was also examined, as well as potential nonspecific disturbances in locomotor activity or signs of acute toxicity. BPIS (25-100 mg/kg) induced an increase in tail-immersion response latency and this effect was significant at pretreatment times of 15 min to 4 h, but not at 8 h. The hot-plate response latency was also increased by the administration of BPIS (25-100 mg/kg). BPIS, at doses of 25 and 50 mg/kg, inhibited writhing behaviour caused by an intraperitoneal acetic acid injection. Both early and late phases of nociception caused by the intraperitoneal formalin injection were inhibited by BPIS (10-50 mg/kg). BPIS, administered at doses equal to or greater than 10 and 25 mg/kg, reduced nociception produced by an intraperitoneal injection of capsaicin and glutamate, respectively. The antinociceptive effect of BPIS, when assessed in the tail-immersion test, was not abolished by naloxone. BPIS (10-50 mg/kg) did not alter alanine transaminase and aspartate transaminase activities (parameters of hepatic function) or urea and creatinine levels (parameters of renal function), and did not affect motor activity in the open-field test. The results indicate that BPIS produced an antinociceptive action without causing motor disturbances or toxicity. Moreover, opioidergic mechanisms seem not to be involved in the antinociceptive action of BPIS. Here, BPIS has been found to be a novel organoselenium compound with antinociceptive properties; however, more studies are required to examine its therapeutic potential for pain treatment.

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Involvement of glutamate and cytokine pathways on antinociceptive effect of Pfaffia glomerata in mice

Cited by 13 publications

References 33 publications

Evaluation of the anti‐inflammatory and antinociceptive effects of myrtenol, a plant‐derived monoterpene alcohol, in mice

Evaluation of the anti‐inflammatory and antinociceptive effects of myrtenol, a plant‐derived monoterpene alcohol, in mice

Eugenol reduces acute pain in mice by modulating the glutamatergic and tumor necrosis factor alpha (TNF‐α) pathways

Bis(phenylimidazoselenazolyl) diselenide

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