Involvement of glucagon-like peptide 1 in the glucose homeostasis regulation in obese and pituitary-dependent hyperadrenocorticism affected dogs

Miceli, Diego Daniel; Blatter, M.F. Cabrera; Gallelli, María Florencia; Pignataro, Omar Pedro; Castillo, V.

doi:10.1016/j.rvsc.2014.07.014

Cited by 10 publications

(10 citation statements)

References 38 publications

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“…The dogs showed the characteristic signs of Cushing Syndrome: polydipsia, polyuria, polyphagia, thin inelastic skin, hair loss, large abdomen, weight gain. The diagnosis was confirmed using the cortisol:creatinine relationship in urine before and after oral administration of dexamethasone (Galac et al, 1997), ACTH stimulation (basal cortisol measurements and 1 h after intravenous administration of 0.25 mg ACTH), plasma ACTH measurements, abdominal ultrasonography to evaluate the morphology and size of the adrenal glands, and Magnetic Resonance of the sellar region (Gallelli et al, 2010;Kooistra and Galac, 2012;Miceli et al, 2014). None of these patients had concurrent diseases (heart disease, clinically evident kidney disease, urinary infections, diabetes mellitus, neoplasia nor systemic infectious diseases) nor were they receiving or had received treatment for PDH prior to this diagnosis.…”

Section: Population Under Study Population With Pdhmentioning

confidence: 99%

Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism

et al. 2018

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Hyperadrenocorticism is a frequent disease in dogs. The excess of circulating cortisol affects different organs and metabolic pathways, producing severe adverse effects that endanger the animal’s life. Among these effects, hypertension and renal damage can be mentioned. A group of 20 dogs with pituitary dependent hyperadrenocorticism (PDH) and 12 control dogs were used to study the following parameters: cortisol and nitric oxide (NO nit/nit) concentrations, diastolic and systolic blood pressure, renal artery resistance index by Doppler ultrasound, the rate of glomerular filtration by radio-renogram excretion and the presence of proteins in urine. Dogs with PDH showed a significantly lower NO nit/nit (P<0.0001) than the controls and this correlated with high values of diastolic and systolic pressure (r = -0.87; P<0.0001 and r = -0.81; P<0.0001 respectively). Most dogs (80%) are hypertensive mainly due to an increase in diastolic pressure, which correlated positively with the UPC (r = 0.8; P<0.001) and negatively with the glomerular rate of filtration (r = -0.58; P=0.007). Systolic pressure only increased in 60% of the cases and did not correlate with the mentioned variables. In PDH the decrease of NO affects blood pressure. The diastolic pressure would seem to have the greatest impact on the kidneys, therefore its evaluation and control are important to avoid and/or control renal damage.

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Section: Population Under Study Population With Pdhmentioning

confidence: 99%

Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism

et al. 2018

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“…Several dogs in the present study were overweight. In people and rodents, obesity can impact enteroendocrine hormone concentrations as well as LPS absorption from the GIT, [42][43][44] but a similar impact of obesity in dogs has not been described and might have a different magnitude or even a different direction. Importantly, the crossover study design should have helped to minimize, if not abolish, the effects of individual variation in body condition as well as other dog-specific factors.…”

Section: Discussionmentioning

confidence: 99%

Effects of oral Akkermansia muciniphila supplementation in healthy dogs following antimicrobial administration

Jugan

Rudinsky

Gordon

et al. 2018

ajvr

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OBJECTIVE To measure effects of oral Akkermansia muciniphila administration on systemic markers of gastrointestinal permeability and epithelial damage following antimicrobial administration in dogs. ANIMALS 8 healthy adult dogs. PROCEDURES Dogs were randomly assigned to receive either A muciniphila (10 cells/kg; n = 4) or vehicle (PBS solution; 4) for 6 days following metronidazole administration (12.5 mg/kg, PO, q 12 h for 7 d). After a 20-day washout period, the same dogs received the alternate treatment. After another washout period, experiments were repeated with amoxicillin-clavulanate (13.5 mg/kg, PO, q 12 h) instead of metronidazole. Fecal consistency was scored, a quantitative real-time PCR assay for A muciniphila in feces was performed, and plasma concentrations of cytokeratin-18, lipopolysaccharide, and glucagon-like peptides were measured by ELISA before (T0) and after (T1) antimicrobial administration and after administration of A muciniphila or vehicle (T2). RESULTS A muciniphila was detected in feces in 7 of 8 dogs after A muciniphila treatment at T2 (3/4 experiments) but not at T0 or T1. After metronidazole administration, mean change in plasma cytokeratin-18 concentration from T1 to T2 was significantly lower with vehicle than with A muciniphila treatment (-0.27 vs 2.4 ng/mL). Mean cytokeratin-18 concentration was lower at T1 than at T0 with amoxicillin-clavulanate. No other significant biomarker concentration changes were detected. Probiotic administration was not associated with changes in fecal scores. No adverse effects were attributed to A muciniphila treatment. CONCLUSIONS AND CLINICAL RELEVANCE Detection of A muciniphila in feces suggested successful gastrointestinal transit following oral supplementation in dogs. Plasma cytokeratin-18 alterations suggested an effect on gastrointestinal epithelium. Further study is needed to investigate effects in dogs with naturally occurring gastrointestinal disease.

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“…The HOMAinsulin sensitivity and HOMAβ-cell function were calculated with nonlinear formulas (Levy et al, 1998) Miceli et al Open Veterinary Journal, (2018), Vol. 8(2): 193-199 ________________________________________________________________________________________________________ 195 http://www.dtu.ox.ac.uk/index.php?maindoc_/homa/) according to the methods previously described (Verkest et al, 2010;Miceli et al, 2014). In those cases in which insulin concentrations exceeded the maximum value allowed by the HOMA calculator, the mathematical formula (Matthews et al, 1985) was used to calculate the aforementioned indices:…”

Section: Homa For Insulin Sensitivity and β-Cell Functionmentioning

confidence: 99%

“…Cortisol antagonises various functions of insulin, and high levels may predispose an individual to insulin resistance, a condition in which the peripheral tissues have a reduced response to insulin (Andrews and Walker, 1999;Miceli et al, 2014;Mazziotti et al, 2017). Indeed, the antagonism of insulin by cortisol is so potent that the glucocorticoid effects are referred to as "diabetogenic" (Van Raalte et al, 2009;Van Raalte and Diamant, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Homeostatic Model Assessment indices (HOMA) are used to evaluate both peripheral insulin sensitivity (HOMAinsulin sensitivity) and the function of pancreatic βcells to produce insulin (HOMAβ-cell function) (Matthews et al, 1985;Verkest et al, 2010;Miceli et al, 2014). Metformin is a biguanide that is commonly used as an oral antidiabetic medication for the treatment of type 2 diabetes mellitus in humans (Herman et al, 2005;Aroda et al, 2015;American Diabetes Association, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism

Miceli¹,

Vidal²,

Batter³

et al. 2018

Open Vet J.

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Hypercortisolism induces a state of insulin resistance that can occur concurrently with fasting hyperglycaemia, dyslipidaemia and diabetes mellitus. Metformin reduces hepatic glucose production and insulin resistance of the skeletal muscle and adipose tissue. The aim of this study was to evaluate the effects of metformin on the control of metabolic disorders of dogs with hyperadrenocorticism (HAC). Twenty-three dogs with HAC were randomly divided into two groups, consisting of a control group and a metformin group (10 mg metformin/kg/12 h). Both groups received the same treatment for HAC. At baseline and 3 months, blood glucose, total cholesterol, triglycerides and insulin concentrations, in addition to urinary cortisol:creatinine ratio, Homeostatic Model Assessment (HOMA) for insulin sensitivity and β-cell function were measured. Dogs treated with metformin showed significantly reduced glycaemia, cholesterolaemia and triglyceridaemia. They also presented reduced hyperinsulinism and insulin resistance, as well as improved pancreatic β-cell function. The implementation of metformin as an adjuvant therapy is effective for the normalisation of metabolic disorders of dogs with HAC.

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Involvement of glucagon-like peptide 1 in the glucose homeostasis regulation in obese and pituitary-dependent hyperadrenocorticism affected dogs

Cited by 10 publications

References 38 publications

Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism

Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism

Effects of oral Akkermansia muciniphila supplementation in healthy dogs following antimicrobial administration

Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism

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