Involvement of Ghrelin Dynamics in Stress-Induced Eating Disorder: Effects of Sex and Aging

Yamada, Chihiro

doi:10.3390/ijms222111695

Cited by 8 publications

(9 citation statements)

References 124 publications

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“…In the already-mentioned Korean study ( Baek et al , 2018 ), 36 out of 142 patients with BE (25%) were men compared with 22% in the overall sample. In the last few years, research has shed more light on the role of sex in EDs, pointing to differences in stress hormones and the ghrelin system ( Yamada, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Clinical correlates and prognostic impact of binge-eating symptoms in major depressive disorder

Olgiati

Fanelli

Atti

et al. 2022

International Clinical Psychopharmacology

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Binge-eating (BE) symptoms are relatively common in major depressive disorder (MDD), but their prognostic role is not fully understood. This study compared two groups of patients with MDD experiencing or not BE symptoms to ascertain differences in terms of clinical manifestations, presence of bipolar features, and antidepressant treatment outcomes. The study involved 482 outpatients collected within the Combining Medications to Enhance Depression Outcomes (CO-MED) trial, who were assessed with scales for depressive and hypomanic symptomatology, suicidality, comorbid mental disorders, and childhood traumas. BE symptoms were reported in 95 patients (20%). Patients with MDD experiencing BE symptoms were characterized by higher scores of negative self-outlook (P = 0.0018), negative outlook of future (P = 0.0014), irritability (P = 0.0043), comorbid anxiety disorders (generalized anxiety disorder: P = 0.0006; panic disorder: P < 0.0001; social phobia: P < 0.0001), obsessive-compulsive disorder (P = 0.0053), hypomanic symptoms (increased talkativeness: P = 0.0029; reduced need for sleep: P = 0.0171), and suicidality (suicidal propensity: P = 0.0013; suicidal risk: P = 0.0148; lifetime suicidal behavior: P = 0.0052). BE symptoms (OR = 2.02; 95% CI = 1.06-3.84) and depression severity (OR = 1.04; 95% CI = 1.00-1.08) were independently associated with lifetime attempted suicide. The presence of BE symptoms might indicate higher severity of depressive disorder. Suicidal risk is a major issue in these patients, whereas the association between BE and bipolar features needs further research.

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Section: Discussionmentioning

confidence: 99%

Clinical correlates and prognostic impact of binge-eating symptoms in major depressive disorder

Olgiati

Fanelli

Atti

et al. 2022

International Clinical Psychopharmacology

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“…[6] reported that the GHRL gene SNPs contributed with many genetic factors to create genetic variation in carcass quality in beef cattle while [7] mentioned that the gene is considered one of candidate genes for milk production traits in water buffalo. [8] referred that the gene polymorphism plays an important role to enhance stress tolerance and support appetite under stress conditions. The major aim of the current study is to investigate of single nucleotide polymorphism effect in GHRL gene on milk production and components as an efficient method of indirect selection or markers assisted selection in dairy herds).…”

Section: Introductionmentioning

confidence: 99%

Relationship of GHRL Gene Polymorphism with Milk Production and Components in Holstein Cows

Shnawa,

Al- Khuzai,

Al-Yaseri

2023

IOP Conf. Ser.: Earth Environ. Sci.

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The current study was conducted in private station located in the middle of Iraq by using 100 samples of blood to determine the effect of GHRL gene polymorphism on milk traits in Holstein cows. Results showed two alleles with co-dominance and three genotypes was detected in the site -97, the allele frequency was 0.72 and 0.28 for G and A allele respectively. Results showed a significant effect of SNP on lactation period length (P<0.01). The cows with mutant genotype (AA) were the longest lactation period (241 day) while the cows with wild genotype were the shortest lactation period. Total milk yield affected significantly (P<0.01) by allele type, the highest quantity of milk yield was in cows with mutant genotype namely, 3366.77 Kg. High significant differences in daily milk yield were reported in cows according the alleles type, AA cows genotypes achieved 13.97 Kg /day compared with the cows with GG genotype which achieved 8.82 kg/day. Milk components such as lactose and protein were affected significantly (P<0.01) by GHRL gene SNP, the highest rate of lactose and protein were noticed in cows with wild genotype namely, 5.45 and 3.60% respectively. Milk fat differed significantly (P<0.05) in cows depending on its genotype, the highest rate was recorded in cows with wild genotype (GG) namely 3.90%.

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“…Стресові фактори можуть впливати на апетит, рухову активність шлунково-кишкового тракту і функцію травлення. Фізіологічна реакція на стрес різниться залежно від того, чи є стрес гострим, чи хронічним [8,9] Гострий стрес зазвичай вважається адаптивним механізмом організму, але хронічний стрес може викликати різні порушення біологічних функцій. Деякі фактори впливають на реакцію апетиту на стресори у парадоксальний спосіб.…”

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Eating disorders in children as a consequence of stress caused by war: general results of the study

Hulich,

Petrenko,

Antomonov

et al. 2023

Dovkil Zdor

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The purpose of the study is to determine eating disorders based on the results of a survey of parents and an analysis of the perception of the behavior of children aged 5-17 in conditions of stress caused by war. Research materials and methods. A large-scale cross-sectional survey of parents of school-age children who were in Ukraine at the time of the start of the war (February 24, 2022) was conducted. A total of 5,165 parents took part in the survey. The survey concerned eating disorders and included information about the gender, age, place and conditions of the child's stay, financial support and the family's access to food, general mental manifestations of stress, eating disorders that arose as a result of military operations, changes in the child's physique, etc. The work uses a specially developed questionnaire based on standardized questionnaires about children's stress and eating disorders. This stage of the work determines the peculiarities of the child's whereabouts in relation to military events (staying in occupied territories, in close proximity to hostilities, in peaceful territory, moving within Ukraine or going abroad) and their impact on the eating behavior of school-aged children. The processing of the results included descriptive statistics, as well as the analysis of the relationships of the variables using conjugation tables by calculating the Spearman's rank coefficient and Pearson's chi-square for qualitative variables. The results. It was established that the absence or decrease of appetite, rapid satiety, change in attitude to food are general stress disorders inherent in the entire studied cohort of children. Statistical analysis revealed that the frequency and duration of eating disorders, appetite, delayed satiety, capriciousness or lack of understanding, somato-vegetative manifestations, the formation of disgust or passion for certain food products in school-age children are related to the intensity and nature of the experienced military stress. Being in occupied territories or near hostilities and subsequent displacement has the greatest impact on the frequency and duration of eating disorders. The formation of long-term eating disorders in all groups is actually a deepening of unhealthy eating habits of schoolchildren, which were demonstrated in previous studies. It is expected that these violations will lead to an increase in the frequency of chronic non-communicable diseases in later life. Conclusions. The obtained results are important for the further interpretation of the results in the framework of the study of children's eating disorders under the conditions of stress caused by the war in Ukraine and providing recommendations for the correction of the detected violations. The research has an important social significance for Ukraine, as it is aimed at solving the psychological and medical consequences of the war.

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Involvement of Ghrelin Dynamics in Stress-Induced Eating Disorder: Effects of Sex and Aging

Cited by 8 publications

References 124 publications

Clinical correlates and prognostic impact of binge-eating symptoms in major depressive disorder

Clinical correlates and prognostic impact of binge-eating symptoms in major depressive disorder

Relationship of GHRL Gene Polymorphism with Milk Production and Components in Holstein Cows

Eating disorders in children as a consequence of stress caused by war: general results of the study

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