Involvement of Gamma Aminobutyric Acid in the Anticonvulsant Effect of the Leaf Methanol Extract of Ruta graveolens L. (Rutaceae) in Mice

Ahmad, A.H.; Amabeoku, G.J.

doi:10.3923/ijp.2013.134.142

Cited by 6 publications

(1 citation statement)

References 24 publications

(19 reference statements)

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“…It is a disorder with psychosocial stigmatization and about 80% of the populations are living in the developing countries. The continuous search of novel compounds with potential biological activity is a routine exercise by researchers to discover therapeutic effect of new or already existing 2,3,4 compounds . The search of novel antiepileptic agent is a global concern because of the side effect, chronic toxicity associated with already existing drugs.…”

Section: Introductionmentioning

confidence: 99%

Anticonvulsant appraisal of benzylideneacetophenone analogues in Swiss mice

2022

PSNNJP

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Background: Diketones and α,β-unsaturated ketone are useful intermediates for the synthesis of antiepileptic moieties. Epilepsy is a neurological disorder that affects about fifty million people worldwide. The aim of the study was to assess benzylideneacetophenone analogues for their potential antiepileptic effects in mice. Methods: The compounds used in the pharmacological assay which include; 4-G), were assayed using three models; Strychnine, Pentylenetetrazole (PTZ) and Maximal Electroshock (MES). The samples were given at 500, 1000 and 1500 mg/kg while standard drug diazepam and distilled water were given at 5 mg and 10 ml/kg intraperitoneal respectively. Convulsion inducing agents (Strychnine 2 mg/kg and PTZ, 100 mg/kg) were administered intraperitoneal 1hour after the administration of test samples while MES model electroconvulsive shock was applied using electroconvulsive machine. Results:The samples (A-G) showed significant (P<0.03, 0.003, 0.0007 and 0.0001) effect in delaying onset of seizure compared to control in strychnine model, while in PTZ model samples (A-F) evaluated at 500,1000 and 1500 mg/kg are equipotent at all the doses by significantly (P<0.0001) and sample G (P<0.0007) reduced the onset of seizure compared to control. However in MES model samples (A-F and G) evaluated at 500, 1000 and 1500 mg/kg are equipotent at all the doses by significantly (P<0.0001; 0.0007), reduced the duration of seizure compared to control respectively. Conclusion: Benzylideneacetophenone analogues showed various effects in control of seizure in all the models used.This effect is due to delayed onset and reduction of seizure duration. The samples could act by stimulating the glycine, Gamma Aminobutyric acid (GABA) receptor, inhibition of GABA Aminotransferase and prolong inactivation of sodium ion channel.

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Section: Introductionmentioning

confidence: 99%

Anticonvulsant appraisal of benzylideneacetophenone analogues in Swiss mice

2022

PSNNJP

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Ruta graveolens: Phytochemistry, Pharmacology, and Biotechnology

Malik¹,

Moraes²,

Amaral³

et al. 2016

Transgenesis and Secondary Metabolism

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Ruta graveolens: Phytochemistry, Pharmacology, and Biotechnology

Malik

Moraes

Amaral

et al. 2016

Reference Series in Phytochemistry

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This reference works series provides a platform for all information on plant metab-olites and phytochemicals, their chemistry, properties, applications, and methods. By the strictest definition, phytochemicals are chemicals derived from plants. However, the term is often used to describe the large number of secondary metabolic compounds found in and derived from plants. These metabolites exhibit a number of nutritional and protective functions for human welfare such as colorants, fragrances and flavorings, amino acids, pharmaceuticals, hormones, vitamins and agrochemi-cals. Besides food, fibers, fuel, cloth and shelter, a vast number of wild plants can hence provide important sources for medicines, especially in developing countries for their traditional health systems. Natural products have inspired and provided the foundation to the bulk of FDA-approved compounds and there is tremendous increase in natural products and natural products derived compounds that have been registered against many prevailing diseases. Natural product industry has shown tremendous growth and is expected to continue to do so in the near future. The present series compiles reference information on various topics and aspects about phytochemicals, including their potential as natural medicine, their role as chemo-preventers, in plant defense, their ecological role, their role in plants as well as for pathogen adaptation, and disease resistance. Volumes in the series also contain information on methods such as metabolomics, genetic engineering of pathways, molecular farming, and obtaining metabolites from lower organisms and marine organisms besides higher plants. The books in the series are hence of relevance in various fields, from chemistry, biology, biotechnology, to pharmacognosy, pharma-cology, botany, or medicine. Each volume is edited by leading experts and contains authoritative contributions by renowned authors. More information about this series at:

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Involvement of Gamma Aminobutyric Acid in the Anticonvulsant Effect of the Leaf Methanol Extract of Ruta graveolens L. (Rutaceae) in Mice

Cited by 6 publications

References 24 publications

Anticonvulsant appraisal of benzylideneacetophenone analogues in Swiss mice

Anticonvulsant appraisal of benzylideneacetophenone analogues in Swiss mice

Ruta graveolens: Phytochemistry, Pharmacology, and Biotechnology

Ruta graveolens: Phytochemistry, Pharmacology, and Biotechnology

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