Involvement of GABAergic, BDNF and Nox-2 mechanisms in the prevention and reversal of ketamine-induced schizophrenia-like behavior by morin in mice

Ben‐Azu, Benneth; Aderibigbe, Adegbuyi Oladele; Ajayi, Abayomi Mayowa; Eneni, Aya-Ebi Okubo; Umukoro, Solomon; Iwalewa, Ezekiel O.

doi:10.1016/j.brainresbull.2018.03.006

Cited by 54 publications

(30 citation statements)

References 80 publications

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“…These results suggest that morin, via its antioxidant and free radical scavenging activity, may reduce the ROS production and lipid peroxidation and may facilitate the maintenance of thiol status. Our results are consistent with various reports showing that morin is a potent antioxidant agent that can improve antioxidant status in various tissues, including the liver, brain, cardiovascular system, and lung (13,14,25,26). A recent study showed that morin increased protein expression and the activity of antioxidant enzymes and suppressed the ROS generation through the Nrf2/HO 1 signaling pathway in lung fibroblast cells (27).…”

Section: Discussionsupporting

confidence: 92%

Protective Effects of Morin Against Bleomycin-Induced Pulmonary Fibrosis in Mice

Hemmati

Pashmforosh

Tabandeh

et al. 2019

Jundishapur J Nat Pharm Prod

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Background: Idiopathic pulmonary fibrosis (IPF) is a fatal and incurable lung disease. Morin, a natural product with antioxidant and anti-inflammatory activity, could reduce lung inflammation induced by lipopolysaccharide (LPS) and liver fibrosis in previous studies. Objectives: The aim of this study was to evaluate the antifibrotic activity of morin in the pulmonary fibrosis induced by bleomycin in mice. Methods: Pulmonary fibrosis was induced by the intratracheal instillation of bleomycin (3 mg/kg) in C57Bl/6J mice. Morin (10, 20, and 40 mg/kg, p.o.) was given to mice from day 0 to 21 after bleomycin administration. The mice were sacrificed on day 21 to measure the total number of cells, the percentage of leukocytes in bronchoalveolar lavage fluid (BALF), lung hydroxyproline content, lung index, and oxidative stress markers. Histopathological changes were evaluated by the microscopic examination of sections stained with hematoxylin-eosin and Masson's trichrome. Results: Our data showed that treatment with morin significantly attenuated the infiltration of inflammatory cells, hydroxyproline content, lung index, and oxidative stress that were elevated in fibrotic lungs. In addition, morin could reduce the pathological changes induced by bleomycin. Conclusions: Based on the study, morin, probably by its anti-inflammatory and antioxidant activities, can attenuate pulmonary fibrosis induced by bleomycin in mice.

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Section: Discussionsupporting

confidence: 92%

Protective Effects of Morin Against Bleomycin-Induced Pulmonary Fibrosis in Mice

Hemmati

Pashmforosh

Tabandeh

et al. 2019

Jundishapur J Nat Pharm Prod

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“…Other systems linked to behavior are the GABAergic system and the concentration of Ca 2+ especially on the periodical muscle contraction which can regulate the cycle of defecation. These patterns can be altered by many natural compounds (Banerjee et al, 2021; Ben‐Azu et al., 2018; Podlešáková et al., 2019).…”

Section: Discussionmentioning

confidence: 99%

Pitaya fruit extract ameliorates the healthspan on copper‐induced toxicity of Caenorhabditis elegans

Tamagno

Santini

Santos

et al. 2022

Journal of Food Biochemistry

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Copper (Cu) is an essential metal and it is important for metabolism. However, in high concentrations, it becomes toxic. Metal‐induced toxicity is the cause of many neurodegenerative diseases. So it is necessary to search mechanisms to find ways of healthy aging. Natural compounds and diets based on fruits are increasingly common and could lead to a healthy life. Pitaya (Hylocereus undatus) is a tropical and Latin American, fruit that is gaining more popularity due to its antioxidant properties. Here, we evaluate the preventive and curative effect of different doses of microencapsulated pulp H. undatus extract on copper‐induced toxicity. For this we use the nematode Caenorhabditis elegans, to investigate the effects of pitaya extract on behavior, lipid peroxidation, antioxidant chaperon, and cholinergic nervous system (ColNS). Results showed behavioral changes, decreased cell death biomarkers, and lipid peroxidation caused by copper, and these toxic effects were prevented and reverted by Pitaya's extract. After all, the extract can be used in diet as a supplement and studied to treat or prevent specific diseases, some of them linked to contamination and senility‐related conditions. Practical applications This research has been aimed to provide the uses of Hylocereus undatus microencapsulated pulp extract for the prevention and treatment of copper‐induced toxicity. We have been shown that Pitaya is a good source of antioxidant compounds that can ameliorate the antioxidant system as well as the cholinergic nervous system avoiding behavior changes before and after the metal toxicity of copper. Therefore, the potential applications and common use of this extract can serve as food supplementation to prevent metal oxidative damage as well as to repair clinical cases of copper poisoning.

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“…The escape‐related mobility of rats was recorded for the next 5 min. Completely inert hind/forelimb indicated immobility (Ben‐Azu et al., 2018).…”

Section: Methodsmentioning

confidence: 99%

Neuroprotective effects of Olea europaea L. fruit extract against cigarette smoke‐induced depressive‐like behaviors in Sprague–Dawley rats

et al. 2021

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Depression is broadly acclaimed as a mental health anomaly and despite advancements in the development of antidepressant drugs, they are linked with side effects. Dietary modifications and medicinal plants like olives can be used as effective strategies due to their antioxidant, immune‐modulatory, antiinflammatory, and anticonvulsant properties. Considering the compositional alterations in olive fruits during ripening, the antidepressant potential of olive fruits at different degrees of ripeness, that is, un‐ripened (green) and ripened (black) was investigated. Rats were randomly divided into five groups: G0 (Normal diet), G1 (Normal diet + smoke exposure (SE), G2 (Normal diet + SE + Citalopram), G3 (Normal diet + SE + Green olive extract), and G4 (Normal diet + SE + Black olive extract). Depressive‐like behaviors were induced in all groups through cigarette smoke exposure except G0. Green and black olive extracts prevented depressive behaviors by reducing the immobility time of rats in forced swim test and tail suspension test while increased the latency to respond in hot plate assay. Moreover, lipid peroxidation in brain tissue was reduced with citalopram, green, and black olive extracts. Additionally, treatments also enhanced the antioxidant pool of brain tissues. Histological examination revealed that olive extracts and citalopram prevented cigarette smoke‐induced moderate to severe necrosis and congestion in the brain parenchyma and elucidated antidepressant potential by improving the expression of monoamine oxidase‐A, solute carrier family 6 member 4, and brain‐derived neurotrophic factor genes. Conclusively, olives may act as a promising antidepressant agent in ameliorating cigarette smoke‐induced depressive‐like behaviors. Practical applications Olive extracts at both ripening stages revealed an antidepressant‐like effect almost similar to the standard antidepressant drug and also prevented oxidative damages. Therefore, from the current findings, it can be recommended that food ingredients with antidepressant potential like olives should be incorporated in future interventions to combat depression/psychiatric anomalies and diet therapy should be encouraged to alleviate lifestyle‐related disorders.

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Involvement of GABAergic, BDNF and Nox-2 mechanisms in the prevention and reversal of ketamine-induced schizophrenia-like behavior by morin in mice

Cited by 54 publications

References 80 publications

Protective Effects of Morin Against Bleomycin-Induced Pulmonary Fibrosis in Mice

Protective Effects of Morin Against Bleomycin-Induced Pulmonary Fibrosis in Mice

Pitaya fruit extract ameliorates the healthspan on copper‐induced toxicity of Caenorhabditis elegans

Neuroprotective effects of Olea europaea L. fruit extract against cigarette smoke‐induced depressive‐like behaviors in Sprague–Dawley rats

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