Involvement of GABAA receptors in the regulation of the prefrontal cortex on dopamine release in the rat dorsolateral striatum

Matsumoto, Machiko; Kanno, Manabu; Togashi, Hiroko; Ueno, Kenichi; Otani, Hiroshi; Mano, Yukio; Yoshioka, Mitsuhiro

doi:10.1016/j.ejphar.2003.10.003

Cited by 31 publications

(30 citation statements)

References 31 publications

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“…If the primary effect of EA while DA is at an excess state is to produce a persistent increase in striatal GABA levels, then one expects the DA release to be diminished and this is indeed what we observed. These data are consistent with prior literature showing the effects of GABA and GABA agonists on DA release [9,22]. Our hypothesis is also in line with the finding that high-frequency activation of corticostriatal fibers led to either long-term depression or long-term potentiation of excitatory transmission (LTD or LTP) depending on the subclass of glutamate receptor and neurons activated [4].…”

Section: Discussionsupporting

confidence: 94%

Inhibition of stimulated dopamine release and hemodynamic response in the brain through electrical stimulation of rat forepaw

Chen

Ren

Wang

et al. 2008

Neuroscience Letters

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The subcortical response to peripheral somatosensory stimulation is not well studied. Prior literature suggests that somatosensory stimulation can affect dopaminergic tone. We studied the effects of electrical stimulation near the median nerve on the response to an amphetamine induced increase in synaptic dopamine. We applied the electrical stimulation close to the median nerve 20 minutes after administration of 3mg/kg amphetamine. We used fMRI and microdialysis to measure markers of DA release, together with the release of associated neurotransmitters of striatal Glutamate (Glu) and GABA.Result-1) Changes in cerebral blood volume (CBV), a marker used in fMRI, indicate that electrical stimulation significantly attenuated increased DA release (due to AMPH) in the striatum, thalamus, medial prefrontal and cingulate cortices. 2) Microdialysis showed that electrical stimulation increased Glu and GABA release and attenuated the AMPH-enhanced DA release. The striatal DA dynamics correlated with the CBV response.Conclusion-These results demonstrate that electrical stimulation near the median nerve activates Glu/GABA release which subsequently attenuate excess striatal DA release. These data provide evidence for physiologic modulation caused by electroacupuncture at points near the median nerve.

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Section: Discussionsupporting

confidence: 94%

Inhibition of stimulated dopamine release and hemodynamic response in the brain through electrical stimulation of rat forepaw

Chen

Ren

Wang

et al. 2008

Neuroscience Letters

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“…There is a crucial relationship between the dopamine level in the prefrontal cortex and the rearing behavior in rodents [13] . Microdialysis study in rodents revealed that bupropion significantly increases the dopamine release in the prefrontal cortex [8] and that diazepam significantly decreases it [14] .…”

Section: Resultsmentioning

confidence: 99%

Pharmacologically Distinctive Behaviors other than Burying Marbles during the Marble Burying Test in Mice

Kuratani

Kinoshita

Hara³

2010

Pharmacology

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In the marble burying test, we focused on the 5 distinctive behavioral parameters of mice other than burying marbles, i.e. digging, latency to the first digging, exploration around marbles, rearing and locomotor activity. Typical anxiolytics or antidepressants with different mechanisms, fluvoxamine (30 mg/kg, selective serotonin reuptake inhibitor), bupropion (60 mg/kg, noradrenaline and dopamine reuptake inhibitor), imipramine (60 mg/kg, tricyclic antidepressant) and diazepam (10 mg/kg, benzodiazepine) were used to examine whether these behavioral parameters are sensitive to pharmacological treatments. Each of the drugs demonstrated an individual action pattern on the 4 behavioral parameters (latency to the first digging, exploration around marbles, rearing and locomotor activity). On the other hand, all 4 drugs reduced burying marbles and digging, which were correlated with each other. These results suggest that the former 4 behavioral parameters are sensitive to pharmacological treatment and that pharmacological regulation mechanisms of them may be different from burying marbles and digging. They could be useful to identify the type of action of a test drug like selective serotonin reuptake inhibitor, noradrenaline and dopamine reuptake inhibitor, tricyclic antidepressant or benzodiazepine.

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“…The NMDA/ GABA interaction is important in the regulation of DA levels in the PFC and striatum (Balla et al, 2009). Reducing GABA transmission in the mPFC with the GABA A receptor antagonist bicuculline or infusion of GLU increased DA release in the dorsal-STR and these effects were abolished by intracortical infusion of MK801 or the GABA A agonist muscimol (Matsumoto et al, 2003). Activation of NMDA receptors on striatal GABA neurons also facilitated GABA release (Morari et al, 1996;Morari et al, 1993Morari et al, , 1994Young and Bradford, 1993).…”

Section: Blockade Of Nmda Receptors In the Mpfc Causes Hyperactivity mentioning

confidence: 95%

Dopamine D1-Like and D2-Like Receptors in the Dorsal Striatum Control Different Aspects of Attentional Performance in the Five-Choice Serial Reaction Time Task Under a Condition of Increased Activity of Corticostriatal Inputs

Agnoli

Mainolfi

Invernizzi

et al. 2012

Neuropsychopharmacol

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We investigated the interaction between the corticostriatal glutamatergic afferents and dopamine D1-like and D2-like receptors in the dorsomedial striatum (dm-STR) in attention and executive response control in the five-choice serial reaction time (5-CSRT) task. The competitive NMDA receptor antagonist 3-(R)-2-carboxypiperazin-4-propyl-1-phosphonic acid (CPP) injected in the mPFC impaired accuracy and increased premature and perseverative responding, raising GLU, DA, and GABA release in the dm-STR. The D1-like antagonist SCH23390 injected in the dm-STR reversed the CPP-induced accuracy deficit but did not affect the increase in perseverative responding. In contrast, the D2-like antagonist haloperidol injected in the dm-STR reduced the CPP-induced increase in perseverative responding but not the accuracy deficit. The different roles of dorsal striatal D1-like and D2-like receptor were further supported by the finding that activation of D1-like receptor in the dm-STR by SKF38393 impaired accuracy but not perseverative responding while the D2-like agonist quinpirole injected in the dm-STR increased perseverative responding but did not affect accuracy. These findings suggest that integration of cortical information by D1-like receptors in the dm-STR is a key mechanism of the input selection process of attention while the integration of corticostriatal signals by D2-like receptors preserves the ability to switch from one act/response to the next in a complex motor sequence, thus providing for behavioral flexibility.

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Involvement of GABAA receptors in the regulation of the prefrontal cortex on dopamine release in the rat dorsolateral striatum

Cited by 31 publications

References 31 publications

Inhibition of stimulated dopamine release and hemodynamic response in the brain through electrical stimulation of rat forepaw

Inhibition of stimulated dopamine release and hemodynamic response in the brain through electrical stimulation of rat forepaw

Pharmacologically Distinctive Behaviors other than Burying Marbles during the Marble Burying Test in Mice

Dopamine D1-Like and D2-Like Receptors in the Dorsal Striatum Control Different Aspects of Attentional Performance in the Five-Choice Serial Reaction Time Task Under a Condition of Increased Activity of Corticostriatal Inputs

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