Involvement of Gaba and Cannabinoid Receptors in Central Food Intake Regulation in Neonatal Layer Chicks: Role of CB1 and Gabaa Receptors

Zendehdel, Morteza; Tirgari, Farrokh; Shohre, B; Deldar, Hamid; Hassanpour, Shahin

doi:10.1590/1806-9061-2016-0438

Cited by 8 publications

(7 citation statements)

References 46 publications

(76 reference statements)

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“…In this respect, the significant attenuating effect of β 2 antagonist on hypophagia induced by ghrelin and leptin has been detected in broiler chickens (Zendehdel and Hassanpour 2014a, b;. Moreover, as mentioned earlier, NE interacts with opioid, 5-HT, oxytocin (OT), and DA (Nayebzadeh et al 2020;Zendehdel et al 2017c;Mirnaghizadeh et al 2017;Zanganeh et al 2020).…”

Section: Norepinephrine (Ne)mentioning

confidence: 90%

“…Also, an interplay has been observed between DA and 5-HT; hypophagic effect of D 1 was attenuated by 5-HT 2C antagonist (Zendehdel et al 2014a). Besides, anorexigenic effect of this ligand is amplified by GABA A receptor antagonist and α 2 receptor antagonist whereas attenuated by NMDA, AMPA/Kainate receptor antagonist, and β 2 receptor antagonist (Zendehdel et al 2017c;Mortezaei et al 2013). Additionally, some receptors of 5-HT (5-HT 2a and 5-HT 2c ) can decrease the anorexigenic effect of harmaline on food desire (Zendehdel et al 2013b).…”

Section: Serotonin (5-hydroxytryptamine 5-ht)mentioning

confidence: 99%

“…NT S are kinds of mediators secreted by neuronal terminals, influencing pre-/postsynaptically. Some of them, such as DA, 5-HT, and ghrelin, decrease food intake in birds, while N/OFQ, CBs, and GABA increase it (Denbow et al 2000;Bungo et al 2009;Zendehdel et al 2014aZendehdel et al , 2017cZendehdel et al , 2013cZendehdel et al , 2019Zendehdel et al , 2017aZendehdel et al , 2008. Among the NT S involved with the food intake regulation, epinephrine, NE, DA, 5-HT, and histamine belong to the subgroup of biogenic amines; however, GABA and glutamate are amino acids, NPY and opioids are recognized as neuropeptides.…”

Section: Introductionmentioning

confidence: 99%

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The Crosstalk Between Brain Mediators Regulating Food Intake Behavior in Birds: A Review

Rahmani

Ghashghayi

Zendehdel

et al. 2021

Int J Pept Res Ther

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Appetite is controlled by a complex system of central and peripheral signals interacting to modulate the ingestion response. Several brain mediators with complex networks adjust food intake in birds. Based on the available literature, these mediators have interactions with a number of other neurotransmitters (NT S ) involved in feed intake. It means that, NT S regulate feeding behavior through mediating other peptide and NTs activity. In birds, insulin known as a hypophagic hormone that is interplaying with neuropeptide Y (NPY), pro-opiomelanocortin (POMC), and corticotropin-releasing factor (CRF) in brain. Another hormone ghrelin, inhibits food intake in birds and other mediators, such as glutamate, endocannabinoid system (ECS), serotonin (5-hydroxytryptamine, 5-HT), and norepinephrine (NE), which play a key role in ghrelin-induced hypophagia. Another involved peptide on feeding behavior in chickens called nociceptin/orphanin FQ (N/OFQ) is modulated by histamine, glutamate, dopamine (DA), gamma-aminobutyric acid (GABA), agouti-related protein (AgRP), and cocaine and amphetamine-regulated transcript (CART). Some of the NT S such as opioid have both orexigenic and anorexigenic effects in birds while has interaction with NE, glutamate, histamine, DA, and cannabinoids (CBs). Thus, interaction among mediators is a prominent process needs to be considered in order to understanding the mechanisms underlying feed intake regulation in birds. This review aims to investigate the role of major regulators and their mediatory interactions with one another in poultry feeding behavior. According to mentioned interactions, it seems that dopamine, serotonin, and glutamate have the most interactions with other NT systems. Therefore, they play an axial role in the central regulation of food intake in CNS.

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Section: Norepinephrine (Ne)mentioning

confidence: 90%

Section: Serotonin (5-hydroxytryptamine 5-ht)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Crosstalk Between Brain Mediators Regulating Food Intake Behavior in Birds: A Review

Rahmani

Ghashghayi

Zendehdel

et al. 2021

Int J Pept Res Ther

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“…27 Another relevant point is that drugs, such as marijuana, are appetite stimulants, so they can increase the consumption of foods, including chocolate. 28,29 Chocolate consumption and infarction Int J Cardiovasc Sci. 2019;32(6):576-582…”

Section: Discussionmentioning

confidence: 99%

Association Between Chocolate Consumption and Severity of First Infarction

Duarte

Oliveira

Jung

et al. 2019

International Journal of Cardiovascular Sciences

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Background: Cardiovascular diseases, such as acute myocardial infarction, are the main causes of death in the world. The flavonoids present in chocolate can have benefits for people who have risk factors to the development of cardiovascular diseases and have a coadjuvant effect on known therapies. Objective: To analyze the association between chocolate consumption, severity of coronary lesions, risk factors and severity of the first infarction in patients attended at the Cardiology Institute of Santa Catarina and other hospitals in the State of Santa Catarina. Methods: Subanalysis of the Catarina Heart Study cohort, evaluated 350 patients with first myocardial infarction. We evaluated clinical, echocardiographic, hemodynamic laboratorial variables. We used chi square test to evaluate qualitative variables, t student test in the case of parametric variables and U Mann Whitney test in non-parametric variables. We considered significant p < 0,05. Results: Lower prevalence of hypertension (43.2% % vs. 62.3% p = 0.003), diabetes mellitus (13.5% vs. 25.7%, p = 0.027) and smoking (24.3% vs. 37.7%, p = 0.032) among those who consume chocolate. Higher use of alcohol (40.5% vs. 26.4%, p = 0.018) and drugs (9.5% vs. 3.3%, p = 0.023) among those who consumed chocolate. Among the patients who consumed chocolate, there was a negative correlation between amount consumed and Syntax (r =-0.296, p = 0.019). Conclusion: There was association between chocolate consumption and lower prevalence of hypertension, diabetes and smoking. There was no association between amount of chocolate consumed and post-infarction ventricular function and TIMI frame count. Higher prevalence of alcohol and drug use among those who consume chocolate. Negative correlation between Syntax and the amount of chocolate consumed.

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“…Feed intake, satiety and energy expenditure regulates via diverse signals from central and peripheral tissues (Hassanpour et al, 2015;Zendehdel et al, 2017). Neurotransmitters interact by a wide distributed neurological network on feed intake regulation in the central nervous system (CNS) (D'Addario et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

CRF1/CRF2 and MC3/MC4 Receptors Affect Glutamate- Induced Food Intake in Neonatal Meat-Type Chicken

Ahmadi

Zendehdel

Babapour

et al. 2019

Braz. J. Poult. Sci.

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Central glutamate, melanocortin and corticotropin systems have mediatory role on several physiologic functions in the brain, but their interactions on appetite regulation are not fully elicited. So, the aim of the current study was to determine interaction of the glutamate with melanocortin and corticotropin systems on food intake in 3-h food-deprived (FD 3 ) neonatal meat-type chicken. In experiment 1, chicken intracerebroventricular (ICV) injected (A) phosphate-buffered saline (PBS), (B) glutamate (75 nmol), (C) glutamate (150 nmol) and (D) glutamate (300 nmol). In experiment 2, (A) PBS, (B) astressin-B (CRF 1 /CRF 2 receptors antagonist, 30 µg), (C) glutamate (300 nmol) and (D) astressin-B+glutamate were ICV injected. Experiments 3-5 were similar to experiment 2, except birds were injected with astressin2-B (CRF 2 receptor antagonist, 30 µg), SHU9119 (MC 3 /MC 4 receptor antagonist, 0.5 nmol) and MCL0020 (MC 4 receptor antagonist, 0.5 nmol) instead of the astressin-B. In experiment 6, the injections were (A) PBS, (B) MTII (MC 3 /MC 4 receptor agonist, 2.5ng), (C) glutamate (75nmol) and (D) MTII+glutamate. Then, cumulative feed intake was recorded at 30, 60 and 120 minutes after injection. According to the results, dose dependent hypophagia observed by ICV injection of the glutamate (75, 150 and 300nmol) compared to control group in neonatal broiler chicken (p<0.05). Co-injection of the astressin-B+glutamate and astressin2-B+glutamate decreased glutamateinduced hypophagia in neonatal broiler chicken (p<0.05). Coinjection of the glutamate+MC 3 /MC 4 receptors antagonist decreased hypophagic effect of the glutamate (p<0.05). These results suggested hypophagic effect of the glutamate mediates via CRF 1 /CRF 2 and MC 3 / MC 4 receptors in chickens.

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Involvement of Gaba and Cannabinoid Receptors in Central Food Intake Regulation in Neonatal Layer Chicks: Role of CB1 and Gabaa Receptors

Cited by 8 publications

References 46 publications

The Crosstalk Between Brain Mediators Regulating Food Intake Behavior in Birds: A Review

The Crosstalk Between Brain Mediators Regulating Food Intake Behavior in Birds: A Review

Association Between Chocolate Consumption and Severity of First Infarction

CRF1/CRF2 and MC3/MC4 Receptors Affect Glutamate- Induced Food Intake in Neonatal Meat-Type Chicken

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