Involvement of ERK1/2 pathway in neuroprotective effects of pyrroloquinoline quinine against rotenone-induced SH-SY5Y cell injury

Pyrroloquinoline quinone (PQQ) producing Escherichia coli Nissle 1917 (EcN) alleviates age associated oxidative stress and hyperlipidemia, and improves mitochondrial function in ageing rats

“…These results are consistent with previous reports describing the role of PQQ in mitochondrial biogenesis pathway (Rucker et al, 2009;Chowanadisai et al, 2010) and its metabolism (Bauerly et al, 2011). Recently it was shown that PQQ protects neuronal cells against rotenone induced damage by ERK1/2 pathway (Zhang et al, 2014). Rotenone has been extensively used to develop Parkinson's disease (PD) rodent model.…”

“…Several recent studies indicated the protective role of PQQ against brain injury (Zhang et al, 2006(Zhang et al, , 2009(Zhang et al, , 2013(Zhang et al, , 2014. Zhang et al (2014) demonstrated the neuroprotective effect of PQQ against rotenone in neuronal cell culture. It is reasonable to say that PQQ might be involved in modulation of animal behaviour and might provide protection against rotenone induced changes in brain physiology.…”

Inhibition of Endoplasmic Reticulum Stress is Involved in the Neuroprotective Effect of bFGF in the 6-OHDA-Induced Parkinson’s Disease Model

“…The PI3K/Akt pathway is necessary for mediating the trophic factor-induced survival of several neuronal cell types [33]. Activated Erk kinase has also been shown to induce the neuronal transdifferentiation of dopaminergic neuron cells [34,35].…”

Pyrroloquinoline quinone-conferred neuroprotection in rotenone models of Parkinson’s disease

“…Unfortunately, most of the commonly used antioxidants have had a limited success in the treatment of PD, possibly because ROS generation from the ETC complex I, II and III is modulated in an insult-specific manner and the ETC sites are differentially accessible to those common antioxidants (Liu and Schubert, 2009). Our recent study has shown that ROS produced by complex I and III inhibitors could be attenuated by PQQ, suggesting these two ROS-generating sites might be accessible to PQQ (Zhang et al, 2014).…”