Involvement of Dopamine in Development of Hypertension in Spontaneously Hypertensive Rat: Effect of Carbidopa, Inhibitor of Peripheral DOPA Decarboxylase

Yoshimura, Manabu; Kambara, Seiichi; Takahashi, Hakuo; Okabayashi, Hideoki; Ijichi, Hamao

doi:10.3109/10641968709159004

Cited by 11 publications

(5 citation statements)

References 18 publications

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“…There is considerable evidence that DA plays an important role in regulating blood pressure through a variety of central and peripheral dopaminergic mechanisms (Taylor et al 1983;Yoshimura et al 1987). In the periphery, DA is involved in the regulation of NA release from sympathetic nerves, regulation of natriuresis in the kidneys and the modulation of release of various hormones such as aldosterone (Yoshimura et al 1993b).…”

Section: Discussionmentioning

confidence: 99%

The effect of exposure to negative air ions on the recovery of physiological responses after moderate endurance exercise

Ryushi

Kita

Sakurai

et al. 1998

International Journal of Biometeorology

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This study examined the effects of negative air ion exposure on the human cardiovascular and endocrine systems during rest and during the recovery period following moderate endurance exercise. Ten healthy adult men were studied in the presence (8,000-10,000 cm-3) or absence (200-400 cm-3) of negative air ions (25 degrees C, 50% humidity) after 1 h of exercise. The level of exercise was adjusted to represent a 50-60% load compared with the subjects' maximal oxygen uptake, which was determined using a bicycle ergometer in an unmodified environment (22-23 degrees C, 30-35% humidity, 200-400 negative air ions.cm-3). The diastolic blood pressure (DBP) values during the recovery period were significantly lower in the presence of negative ions than in their absence. The plasma levels of serotonin (5-HT) and dopamine (DA) were significantly lower in the presence of negative ions than in their absence. These results demonstrated that exposure to negative air ions produced a slow recovery of DBP and decreases in the levels of 5-HT and DA in the recovery period after moderate endurance exercise. 5-HT is thought to have contributed to the slow recovery of DBP.

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Section: Discussionmentioning

confidence: 99%

The effect of exposure to negative air ions on the recovery of physiological responses after moderate endurance exercise

Ryushi

Kita

Sakurai

et al. 1998

International Journal of Biometeorology

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“…Urinary Excretion of DOPA and DA during Altered Dietary Intake Dietary salt loading increases urinary DA excretion in animals (21,29) and humans (30)(31)(32). Consistent with sodium-induced compensatory activation of a renal dopaminergic natriuretic system, administration of the DOPA decarboxylase inhibitor, carbidopa, impairs natriuresis acutely, with the magnitude of impairment correlated with the magnitude of decrease in DA excretion (33)(34)(35)(36). Dietary salt loading also increases urinary excretion of DOPA in animals (21) and humans (31,32).…”

Section: Da-inducedmentioning

confidence: 91%

Is There a Third Peripheral Catecholaminergic System? Endogenous Dopamine as an Autocrine/ Paracrine Substance Derived from Plasma DOPA and Inactivated by Conjugation

et al. 1995

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In mammals, the sympathetic neurotransmitter is norepinephrine (NE), and the main adrenomedullary hormone is epinephrine (EPI). The sources and physiological roles of the third endogenous catecholamine, dopamine (DA), outside the brain have been obscure. Several lines of evidence suggest that in the periphery, rather than DA serving only as the precursor for the active compounds, released from sympathetic nerves and the adrenal medulla, DA may also act as an autocrine/paracrine regulator of local organ function. Thus, in the kidneys, most of DA formation appears to be from proximal tubular uptake of plasma DOPA, and binding of locally formed DA to dopaminergic receptors decreases Na/K ATPase activity and thereby accentuates natriuresis. In the gastric mucosa, DA may modulate sodium absorption and acid secretion. Recent clinical and laboratory animal evidence has indicated that the lungs and mesenteric organs contribute substantially to total body production and metabolism of DA. Generation of DA in non-noradrenergic, non-adrenergic cells can explain why human urine contains higher concentrations of DA and its metabolites than of NE and its metabolites. The vast preponderance of plasma DA in humans is sulfoconjugated. Since patients with sympathoneural failure have normal plasma levels of DA sulfate, one may speculate that the sulfoconjugating mechanism is relatively independent of sympathetic nerves and acts to localize DA effects and inactivate DA entering the circulation. These considerations lead to the concept of a third peripheral catecholaminergic system, where DA derived from plasma DOPA acts as an autocrine/paracrine substance and is inactivated by conjugation.

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“…SHR kidneys show uncoupling between the D 1 -like receptor and its effector enzyme complex in proximal tubules, leading to a failure of dopamine to inhibit proximal tubular luminal sodium/hydrogen exchanger and sodium/potassium ATPase activity. Chronic inhibition of dopamine biosynthesis accelerates the development of hypertension in SHR [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Open-loop analysis on sympathetically mediated arterial pressure and urine output responses in spontaneously hypertensive rats: effect of renal denervation

et al. 2021

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Primary acute sympathetic activation (PASA) causes a subsequent arterial pressure (AP) elevation. In this case, an antidiuretic effect via the renal innervation and pressure diuresis can act antagonistically on the kidneys. We examined the effect of PASA on urine output in spontaneously hypertensive rats (SHR) 4–7 days after unilateral renal denervation (RDN) (n = 9). The slope of the plot of urine flow versus AP was positive (0.120 ± 0.031 μL min−1 kg−1 mmHg−1) on the intact side, but it was less than 1/3 of the slope observed previously in normotensive Wistar–Kyoto rats (WKY). RDN did not normalize the slope of urine flow versus AP (0.179 ± 0.025 μL min−1 kg−1 mmHg−1, P = 0.098 versus the intact side). The urine flow at the operating point of the AP tended to be greater on the denervated than the intact side (29.0 ± 1.8 vs. 25.3 ± 1.9 μL min−1 kg−1, P = 0.055). The percent increase (17.2 ± 7.2%) was not different from that observed previously in WKY. Although high-resting sympathetic nerve activity is prerequisite for maintaining hypertension in SHR, the effect of sympathetic innervation on the urine output function was not greater than that in WKY.

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Involvement of Dopamine in Development of Hypertension in Spontaneously Hypertensive Rat: Effect of Carbidopa, Inhibitor of Peripheral DOPA Decarboxylase

Cited by 11 publications

References 18 publications

The effect of exposure to negative air ions on the recovery of physiological responses after moderate endurance exercise

The effect of exposure to negative air ions on the recovery of physiological responses after moderate endurance exercise

Is There a Third Peripheral Catecholaminergic System? Endogenous Dopamine as an Autocrine/ Paracrine Substance Derived from Plasma DOPA and Inactivated by Conjugation

Open-loop analysis on sympathetically mediated arterial pressure and urine output responses in spontaneously hypertensive rats: effect of renal denervation

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