Involvement of dopamine, but not norepinephrine, in the sex-specific regulation of juvenile socially rewarding behavior by vasopressin

Bredewold, Remco; Nascimento, Nara F.; Ro, Grace S; Cieslewski, Shannon E; Reppucci, Christina J.; Veenema, Alexa H.

doi:10.1038/s41386-018-0100-2

Cited by 29 publications

(15 citation statements)

References 42 publications

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“…AVP fiber density in the LS is significantly higher in male than in female rats, 51 and female rats show higher V 1A binding density than males. 52 Also, Bredewold and colleagues 20 showed that manipulation of the AVP system in the LS is associated with sex-specific responses in social play behavior, a natural reward. In addition, different responses in AVP LS content were observed in male and female rats after acute AMPH administration.…”

Section: Discussionmentioning

confidence: 99%

Vasopressin in the lateral septum decreases conditioned place preference to amphetamine and nucleus accumbens dopamine release

et al. 2019

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The lateral septum (LS) is a limbic nucleus interconnected with several brain areas involved in the regulation of mood and reward. Vasopressin (AVP) is a neuropeptide that has been related to the effects of drugs of abuse, but its role in the addictive process is poorly understood. LS expresses a high density of AVP 1A receptors (V 1A). The aim of this work was to examine whether the modulation of LS AVP system affects the behavioral and neurochemical responses to amphetamine (AMPH) in male rats. Our results show that AMPH-induced conditioned place preference (CPP) produces a decrease in LS AVP content. Besides, we demonstrate that the microinjection of AVP in the LS impairs the expression of AMPH-induced CPP and that this effect is mediated by the activation of the V 1A receptor in the LS. AVP microinjection in the LS elicited a decrease in neuronal activity in the nucleus accumbens (NAc) in animals subjected to AMPH conditioning. Finally, AVP microinjection in the LS decreased dopamine (DA) release in the NAc. Overall, our data demonstrate that intra-LS AVP diminishes the expression of AMPH conditioning behavior while decreasing neuronal activity and DA release in the NAc. Presumably, the effects of AVP in the LS produce an inhibition of GABAergic projections to the VTA, increasing local inhibitory tone in this nucleus, which in turn reduces the activity of DA projections to NAc. Thus, these results contribute to the knowledge about the role of AVP in LS in regulating the reward circuit and addictive like behaviors.

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Section: Discussionmentioning

confidence: 99%

Vasopressin in the lateral septum decreases conditioned place preference to amphetamine and nucleus accumbens dopamine release

et al. 2019

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“…One possible site of OT-V1aR cross-talk is the lateral septum (LS). The dorsal LS has V1aR expression and abundant AVP and OT fibers (68), and V1aR modulate social play behavior by inducing dopamine release (69). Ventral LS has strong OTR expression as well as AVP and OT fibers (68).…”

Section: Oxytocin In Vta and Nac Facilitates Social Approachmentioning

confidence: 99%

Complementary Neural Circuits for Divergent Effects of Oxytocin: Social Approach Versus Social Anxiety

Steinman

Duque-Wilckens

Trainor

2019

Biological Psychiatry

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Oxytocin (OT) is widely known for promoting social interactions but there is growing appreciation that it can sometimes induce avoidance of social contexts. The social salience hypothesis posed an innovative solution to these apparently opposing actions, by proposing that OT enhances the salience of both positive and negative social interactions. The mesolimbic dopamine system was put forth as a likely system to evaluate social salience, due to its well described role in motivation. Evidence from several sources supports the premise that OT acting within the nucleus accumbens and ventral tegmental area facilitate social reward and approach behavior. However, in aversive social contexts, additional pathways play critical roles in mediating the effects of OT. Recent data indicate that OT acts in the bed nucleus of the stria terminalis to induce avoidance of potentially dangerous contexts. Here, we review evidence for neural circuits mediating the effects of OT in appetitive and aversive social contexts. Specifically, we propose that distinct but potentially overlapping neural circuits mediate OT-dependent social approach or social avoidance. We conclude that a broader and more inclusive consideration of neural circuits of social approach and avoidance is needed as the field continues to evaluate the potential of OT-based therapeutics.

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“…Lastly, while sex differences in the current set of behavioral experiments were minimal, we would encourage the continued use of both sexes in future investigations of the neural substrates underlying social versus food preference [52,53]. This is critical because an absence of sex differences in behavior could still be caused by sex differences in its neural underpinnings [54], and we and others have demonstrated that the neural mechanisms underlying motivated social behavior can differ in males and females [34,[55][56][57][58][59][60].…”

Section: The Social Versus Food Preference Test Is a Flexible Behavmentioning

confidence: 91%

Wistar rats and C57BL/6J mice differ in their motivation to seek social interaction versus food in the Social versus Food Preference Test

Reppucci

Brown

Chambers

et al. 2020

Preprint

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Here we characterized the Social versus Food Preference Test, a behavioral paradigm designed to investigate the competition between the choice to seek social interaction versus the choice to seek food. We assessed how this competition was modulated by internal cues (social isolation, food deprivation), external cues (time-of-testing, stimulus salience), sex (males, females), age (adolescents, adults), and rodent model (Wistar rats, C57BL/6J mice). We found that changes in stimulus preference in response to the internal and external cue manipulations were similar across cohorts. Specifically, social over food preference scores were reduced by food deprivation and social familiarly in Wistar rats and C57BL/6J mice of both sexes. Interestingly, the degree of food deprivation-induced changes in stimulus investigation patterns were greater in adolescents compared to adults in Wistar rats and C57BL/6J mice. Strikingly, baseline stimulus preference and investigation times varied greatly between rodent models: across manipulations, Wistar rats were generally more social-preferring and C57BL/6J mice were generally more food-preferring. Adolescent Wistar rats spent more time investigating the social and food stimuli than adult Wistar rats, while adolescent and adult C57BL/6J mice investigated the stimuli a similar amount. Neither social isolation nor time-of-testing altered behavior in the Social versus Food Preference Test. Together, our results indicate that the Social versus Food Preference Test is a flexible behavioral paradigm suitable for future interrogations of the peripheral and central systems that can coordinate the expression of stimulus preference related to multiple motivated behaviors.Running Head: SOCIAL VS. FOOD 3 HIGHLIGHTS  Rats prefer social over food when sated, and this is attenuated by food deprivation.  Mice have no preference when sated, and prefer food over social when food-deprived.  Rats prefer a familiar social stimulus or a novel social stimulus over food.  Mice prefer food over a familiar social stimulus.  Adolescent rats investigate social and food stimuli longer than adult rats. GRAPHICAL ABSTRACTRunning Head: SOCIAL VS. FOOD

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Involvement of dopamine, but not norepinephrine, in the sex-specific regulation of juvenile socially rewarding behavior by vasopressin

Cited by 29 publications

References 42 publications

Vasopressin in the lateral septum decreases conditioned place preference to amphetamine and nucleus accumbens dopamine release

Vasopressin in the lateral septum decreases conditioned place preference to amphetamine and nucleus accumbens dopamine release

Complementary Neural Circuits for Divergent Effects of Oxytocin: Social Approach Versus Social Anxiety

Wistar rats and C57BL/6J mice differ in their motivation to seek social interaction versus food in the Social versus Food Preference Test

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