“…1,18 FGFR-2 and associated receptors are known to be explicitly involved in eye development. [19][20][21][22] Sporadic cases of aniridia, anisocoria, blue sclera, cataract, corectopia, ectopia lentis, glaucoma, iris coloboma, megalocornea, microcornea have been described in Crouzon syndrome, whereas albinoid alterations of the fundus, among other conditions, have been associated with Apert syndrome. 4,15,23 Therefore, given the extensive connective tissue involvement seen with FGFR-2 mutations, and the receptor's role in extracellular matrix composition, including the role of FGFR-2 in the formation of corneal epithelium and periocular mesenchyme derived from cephalic neural crest cells, it is not surprising that globe development could be affected.…”