1999
DOI: 10.1046/j.1365-2443.1999.00259.x
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Involvement of CRM1, a nuclear export receptor, in mRNA export in mammalian cells and fission yeast

Abstract: Background: CRM1, an evolutionarily conserved protein, was shown to be a receptor for leucinerich nuclear export signal (NES)-dependent protein transport. In lower eukaryotes CRM1 is reported to be required for the export of mRNA, however, involvement of the NES-dependent transport pathway in mRNA export in higher eukaryotes has not been established.

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Cited by 41 publications
(36 citation statements)
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References 29 publications
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“…However, there has been little information on the effects of these drugs on the expression of exportins, which might be correlated to their growth inhibitory activity. Therefore, in the present study, we examined the effects of DVD on expression of XPO1 (14,17) and XPOt (8) which play essential roles in the transport namics Tokyo Ltd., Tokyo, Japan) as described previously (9,11,15). The results indicated that the gene expression of XPO1 was reduced time-dependently by 20% and that of XPOt by 40% after 72 h of the DVD treatment (Fig.…”
mentioning
confidence: 66%
“…However, there has been little information on the effects of these drugs on the expression of exportins, which might be correlated to their growth inhibitory activity. Therefore, in the present study, we examined the effects of DVD on expression of XPO1 (14,17) and XPOt (8) which play essential roles in the transport namics Tokyo Ltd., Tokyo, Japan) as described previously (9,11,15). The results indicated that the gene expression of XPO1 was reduced time-dependently by 20% and that of XPOt by 40% after 72 h of the DVD treatment (Fig.…”
mentioning
confidence: 66%
“…To examine whether eIF4G, eIF4E, and the eIF4E kinase, Mnk1, actively shuttle between the nucleus and the cytoplasm using this pathway, we treated cells with LMB, an inhibitor of CRM1-/exportin 1-mediated nuclear export (28,55). NIH 3T3 cells were transfected with vectors containing either FLAG-tagged eIF4GI (46) or a myctagged version of Mnk1 (56). After 48 h, cells were treated with LMB for 3 h and the endogenous eIF4E and eIF4GI or transfected FLAG-eIF4GI or myc-Mnk1 was localized using the appropriate antibody (Fig.…”
Section: Vol 21 2001 Eif4g Interacts With Cbc In the Nucleus 3635mentioning
confidence: 99%
“…Studies in Scizosaccharomyces pombe identified the cellular target of LMB as the CRM1 (chromosomal region maintenance)/exportin 1 protein (11), which is critical for the export of RNA and proteins containing a nuclear export sequence (NES). In the case of RNA export, CRM1 binds to ribonuclear proteins containing the NES motif (12)(13)(14)(15). For example, the export of Rev-response element-containing human immunodeficiency virus (HIV) RNA is inhibited by LMB (13).…”
mentioning
confidence: 99%