Involvement of claudin-7 in HIV infection of CD4(-) cells

Zheng, Junying; Xie, Yiming; Campbell, Richard A.; Jun, Sangook; Massachi, Samira; Razi, Miriam; Chiu, Robert; Berenson, James R.; Yang, Otto O.; Chen, Irvin S. Y.; Pang, Shen

doi:10.1186/1742-4690-2-79

Cited by 22 publications

(7 citation statements)

References 37 publications

(53 reference statements)

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“…50 Perhaps the most novel use of claudins as adhesion receptors is in HIV infection, where the virus was shown to anchor claudin-7 to its envelop and use this protein to adhere-to and infect CD4(-) target cells. 51 Thus, while the expression of claudins at the basal membrane function to regulate beneficial cell/ECM interactions and cell signaling, this important function can also be used to promote cellular adhesion in disease processes that are not beneficial such as the adhesion of metastatic cells to promote cancer progression or to promote HIV infection.…”

Section: Basal Membrane Claudins-cellular/extracellular Matrix Interactionsmentioning

confidence: 99%

Non-canonical functions of claudin proteins: Beyond the regulation of cell-cell adhesions

Hagen

2017

Tissue Barriers

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Tight junctions form a barrier to the diffusion of apical and basolateral membrane proteins thus regulating membrane polarity. They also regulate the paracellular movement of ions and water across epithelial and endothelial cells so that functionally they constitute an important permselective barrier. Permselectivity at tight junctions is regulated by claudins, which confer anion or cation permeability, and tightness or leakiness, by forming several highly regulated pores within the apical tight junction complex. One interesting feature of claudins is that they are, more often than not, localized to the basolateral membrane, in intracellular cytoplasmic vesicles, or in the nucleus rather than to the apical tight junction complex. These intracellular pools of claudin molecules likely serve important functions in the epithelium. This review will address the widespread prevalence of claudins that are not associated with the apical tight junction complex and discuss the important and emerging non-traditional functions of these molecules in health and disease.

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Section: Basal Membrane Claudins-cellular/extracellular Matrix Interactionsmentioning

confidence: 99%

Non-canonical functions of claudin proteins: Beyond the regulation of cell-cell adhesions

Hagen

2017

Tissue Barriers

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“…Known targets are for example claudin 1, claudin 6 and claudin 9, which have been identified as coreceptors for hepatitis C virus (HCV) entry [64]. Claudin 7 is involved in the infection of CD4(-) cells through HIV-1 [65] and the HIV-1 Tat protein is held to be responsible for an increased permeability of the BBB by influencing claudins [66], [67]. Possibly, disturbance of the BBB could be enhanced by an interaction of Nef and CLDN10.…”

Section: Discussionmentioning

confidence: 99%

Brain Transcriptome-Wide Screen for HIV-1 Nef Protein Interaction Partners Reveals Various Membrane-Associated Proteins

et al. 2012

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HIV-1 Nef protein contributes essentially to the pathology of AIDS by a variety of protein-protein-interactions within the host cell. The versatile functionality of Nef is partially attributed to different conformational states and posttranslational modifications, such as myristoylation. Up to now, many interaction partners of Nef have been identified using classical yeast two-hybrid screens. Such screens rely on transcriptional activation of reporter genes in the nucleus to detect interactions. Thus, the identification of Nef interaction partners that are integral membrane proteins, membrane-associated proteins or other proteins that do not translocate into the nucleus is hampered. In the present study, a split-ubiquitin based yeast two-hybrid screen was used to identify novel membrane-localized interaction partners of Nef. More than 80% of the hereby identified interaction partners of Nef are transmembrane proteins. The identified hits are GPM6B, GPM6A, BAP31, TSPAN7, CYB5B, CD320/TCblR, VSIG4, PMEPA1, OCIAD1, ITGB1, CHN1, PH4, CLDN10, HSPA9, APR-3, PEBP1 and B3GNT, which are involved in diverse cellular processes like signaling, apoptosis, neurogenesis, cell adhesion and protein trafficking or quality control. For a subfraction of the hereby identified proteins we present data supporting their direct interaction with HIV-1 Nef. We discuss the results with respect to many phenotypes observed in HIV infected cells and patients. The identified Nef interaction partners may help to further elucidate the molecular basis of HIV-related diseases.

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“…This protein can serve as a receptor for HIV-1 infection of CD4(-) cells or as a ligand on the viral envelope (Zheng et al 2005). …”

Section: Discussionmentioning

confidence: 99%

Expression of Claudin-7 Molecule in Canine Perianal GlandTumours

et al. 2010

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The present study evaluated the expression of claudin-7 in 10 intact perianal gland and 67 hyperplastic and neoplastic lesions of the canine perianal (hepatoid) gland. The results have shown intense typical membrane expression of claudin-7 in intact perianal glands, hyperplasia, adenoma, differentiated and anaplastic carcinoma of this gland. In intact glands, hyperplasias, adenomas of the hepatoid gland, normal, hyperplastic and neoplastic basal cells never expressed claudin-7 molecule. Epitheliomas of the hepatoid gland were negative for claudin-7 molecule. Intense membrane-bound claudin-7 immunoreactivity was found in well-differentiated carcinomas, in addition claudin-7 overexpression in poorly differentiated carcinomas of the canine hepatoid gland. Claudin-7 seems to be one of the integral constituents of tight junction structures of intact perianal gland. In addition, claudin-7 seems to be helpful in distinguishing well-differentiated carcinomas and poorly differentiated carcinomas from epitheliomas of the gland; and in distinguishing well-differentiated carcinomas from adenoma of the perianal gland. Canine, hepatoid gland tumours, claudin-7, immunohistochemistryPerianal or hepatoid glands are modified sebaceous glands in canines located mainly in perianal skin but they also occur in the skin lateral to the prepuce, in the dorsal lumbosacral region, along the ventral midline area, and circumferentially around the proximal third of the tail. The cells of the lobules of these glands can be divided into two groups: mature hepatoid cells and peripheral basal reserve cells (Isitior and Weinman 1979). The function of the hepatoid glands is unknown. The perianal glands have been of interest to veterinarians because they frequently give rise to tumours. The proliferative and neoplastic lesions of the hepatoid gland include hyperplasia, adenoma, epithelioma, well differentiated and poorly differentiated carcinoma. The hepatoid gland hyperplasia and adenoma are common lesions in canines and account for 8% to 18% of all canine skin tumours (Goldschmidt and Hendrick 2000). The hepatoid gland epitheliomas are of low-grade malignancy. These neoplasms are characterized by the majority of cells being reserve cells, with fewer hepatoid cells (Goldschmidt and Shofer 1992). Well-differentiated hepatoid gland carcinomas have a similar histological architecture and morphology to adenomas, but infiltrative growth is present at the tumour margins. Small foci of well-differentiated carcinoma may occur within adenomas, which may represent carcinoma in situ. Poorly differentiated carcinomas of the perianal gland are invasive masses comprising trabeculae and cords of large, polygonal cells (Ihrke et al. 2006).Claudins are a relatively large family of 17-27 kDa integral membrane tight junction tetraspanin proteins that are classified on the basis of the size of the molecules that pass through the paracellular spaces between epithelial and endothelial cells. Phone: +36-1-478-4181 Fax: +36-1-478-4284 E-mail: Jakab.Csaba@aotk.szi...

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Involvement of claudin-7 in HIV infection of CD4(-) cells

Abstract: Background: Human immunodeficiency virus (HIV) infection of CD4(-) cells has been demonstrated, and this may be an important mechanism for HIV transmission.

Cited by 22 publications

References 37 publications

Non-canonical functions of claudin proteins: Beyond the regulation of cell-cell adhesions

Non-canonical functions of claudin proteins: Beyond the regulation of cell-cell adhesions

Brain Transcriptome-Wide Screen for HIV-1 Nef Protein Interaction Partners Reveals Various Membrane-Associated Proteins

Expression of Claudin-7 Molecule in Canine Perianal GlandTumours

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