Involvement of central and peripheral cannabinoid receptors on antinociceptive effect of tetrahydrocannabinol in muscle pain

Bagüés, Ana; Martı́n, Marı́a Isabel; Sánchez, Esteban Fernández

doi:10.1016/j.ejphar.2014.10.016

Cited by 22 publications

(9 citation statements)

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“…in a rat model of acute muscle pain produced antinociceptive effects, which was blocked by the CB 1 R antagonist AM281 and to a lesser extent by the CB 2 R antagonist AM630 (0.5 mg/kg i.p.). 40 Furthermore, in a model of inflammatory and neuropathic pain, mice lacking CB 1 R in peripheral nociceptive neurons showed a reduced analgesic effect to local and systemic administration of the cannabinoid WIN55,212-2. With intrathecal application, the analgesic effect of WIN55,212-2 was absent, suggesting that peripheral CB 1 R in nociceptive neurons plays an important role in producing the analgesic effects of cannabinoids.…”

Section: Discussionmentioning

confidence: 99%

The Cannabinoids Δ⁸THC, CBD, and HU-308 Act via Distinct Receptors to Reduce Corneal Pain and Inflammation

Thapa

Cairns

Szczesniak

et al. 2018

Cannabis and Cannabinoid Research

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Background and Purpose: Corneal injury can result in dysfunction of corneal nociceptive signaling and corneal sensitization. Activation of the endocannabinoid system has been reported to be analgesic and anti-inflammatory. The purpose of this research was to investigate the antinociceptive and anti-inflammatory effects of cannabinoids with reported actions at cannabinoid 1 (CB1R) and cannabinoid 2 (CB2R) receptors and/or noncannabinoid receptors in an experimental model of corneal hyperalgesia.Methods: Corneal hyperalgesia (increased pain response) was generated using chemical cauterization of the corneal epithelium in wild-type (WT) and CB2R knockout (CB2R−/−) mice. Cauterized eyes were treated topically with the phytocannabinoids Δ8-tetrahydrocannabinol (Δ8THC) or cannabidiol (CBD), or the CBD derivative HU-308, in the presence or absence of the CB1R antagonist AM251 (2.0 mg/kg i.p.), or the 5-HT1A receptor antagonist WAY100635 (1 mg/kg i.p.). Behavioral pain responses to a topical capsaicin challenge at 6 h postinjury were quantified from video recordings. Mice were euthanized at 6 and 12 h postcorneal injury for immunohistochemical analysis to quantify corneal neutrophil infiltration.Results: Corneal cauterization resulted in hyperalgesia to capsaicin at 6 h postinjury compared to sham control eyes. Neutrophil infiltration, indicative of inflammation, was apparent at 6 and 12 h postinjury in WT mice. Application of Δ8THC, CBD, and HU-308 reduced the pain score and neutrophil infiltration in WT mice. The antinociceptive and anti-inflammatory actions of Δ8THC, but not CBD, were blocked by the CB1R antagonist AM251, but were still apparent, for both cannabinoids, in CB2R−/− mice. However, the antinociceptive and anti-inflammatory actions of HU-308 were absent in the CB2R−/− mice. The antinociceptive and anti-inflammatory effects of CBD were blocked by the 5-HT1A antagonist WAY100635.Conclusion: Topical cannabinoids reduce corneal hyperalgesia and inflammation. The antinociceptive and anti-inflammatory effects of Δ8THC are mediated primarily via CB1R, whereas that of the cannabinoids CBD and HU-308, involve activation of 5-HT1A receptors and CB2Rs, respectively. Cannabinoids could be a novel clinical therapy for corneal pain and inflammation resulting from ocular surface injury.

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Section: Discussionmentioning

confidence: 99%

The Cannabinoids Δ⁸THC, CBD, and HU-308 Act via Distinct Receptors to Reduce Corneal Pain and Inflammation

Thapa

Cairns

Szczesniak

et al. 2018

Cannabis and Cannabinoid Research

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“…In addition, the role of the CB2 receptors (which are mostly peripherally distributed) in muscle and tendon pain relief in fibromyalgia following cannabis treatment is not clear. There are nearly no reports about the existence of CB2 receptors in the muscles or tendons [ 20 ]. One of the theories behind the pathogenesis of fibromyalgia, however, is endocannabinoid deficiency.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Medical Cannabis on Pain Level and Quality of Sleep among Rheumatology Clinic Outpatients

Khazin¹,

Artul

2021

Pain Research and Management

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Introduction. Medical cannabis (MC) is becoming increasingly popular for the treatment of chronic pain conditions. In this study, we evaluated the effect of MC treatment on pain level and quality of sleep of patients with different medical conditions at the rheumatology clinic. Methods. Patients licensed for the use of MC at the rheumatology clinics at different settings were located and contacted. Their demographic and clinical parameters were documented, including type of medical cannabis consumed, way of consumption, and current monthly consumed amount. These patients were contacted by phone and asked about the effect on pain level and quality of sleep. Results. A total of 351 patients were located, and 319 completed the questionnaire. Mean age was 46 ± 12 years, 76% were female, 82% had fibromyalgia, ∼9% had mechanical problems, ∼4% had inflammatory problems, ∼4% had neurological problems, and ∼1% had other problems. The average monthly consumed dose of MC was 31, 35, 36, and 32 g, with mean pain level reduction of 77%, 82%, 83%, and 57%, and mean sleep quality improvement of 78%, 71%, 87%, and 76% among patients with fibromyalgia, mechanical, neuropathic, and inflammatory problems, respectively. Mean THC and CBD contents were 18.38% ± 4.96 and 2.62% ± 4.87, respectively. The THC concentration, duration of MC consumption, and MC consumption dose had independent significant correlations with pain reduction while only the duration of MC consumption had an independent significant correlation with sleep quality improvement. Conclusions. MC had a favorable effect on pain level and quality of sleep among all spectrums of problems at the rheumatology clinic.

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“…Cannabinoid agonists and endocannabinoids exhibited strong antinociceptive activity via activation of CB1 in spinal cord level in different animal models of pain (31)(32)(33).…”

Section: Discussionmentioning

confidence: 99%

Involvement of Spinal CB1 Cannabinoid Receptors on the Antinociceptive Effect of Celecoxib in Rat Formalin Test

Rezaeian

Vardanjani

Pashmforoosh

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: The pivotal role of cyclooxygenase-2 (COX-2) inhibitors in inflammatory pain is well documented, but its mechanism is not entirely clear. Nonsteroidal anti-inflammatory drugs (NSAIDs) as inhibitors of COX could inhibit fatty acid amide hydrolase, the enzyme responsible for the metabolism of endocannabinoids. Therefore, it is expected that celecoxib administration (selective COX-2 inhibitor) preserve the increased level of endocannabinoids after noxious stimuli, which leads to more pain suppression. Objectives: This study was designed to evaluate the interaction between the intrathecally administered celecoxib in combination with rimonabant, a selective cannabinoid CB1 receptor antagonist/reverse agonist on the pain behavior induced by formalin test in rat. Materials and Methods: Male Wistar rats with inserted lumbar intrathecal catheters were randomly grouped and tested in blinded

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Involvement of central and peripheral cannabinoid receptors on antinociceptive effect of tetrahydrocannabinol in muscle pain

Cited by 22 publications

References 50 publications

The Cannabinoids Δ⁸THC, CBD, and HU-308 Act via Distinct Receptors to Reduce Corneal Pain and Inflammation

The Cannabinoids Δ⁸THC, CBD, and HU-308 Act via Distinct Receptors to Reduce Corneal Pain and Inflammation

The Effect of Medical Cannabis on Pain Level and Quality of Sleep among Rheumatology Clinic Outpatients

Involvement of Spinal CB1 Cannabinoid Receptors on the Antinociceptive Effect of Celecoxib in Rat Formalin Test

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Involvement of central and peripheral cannabinoid receptors on antinociceptive effect of tetrahydrocannabinol in muscle pain

Cited by 22 publications

References 50 publications

The Cannabinoids Δ8THC, CBD, and HU-308 Act via Distinct Receptors to Reduce Corneal Pain and Inflammation

The Cannabinoids Δ8THC, CBD, and HU-308 Act via Distinct Receptors to Reduce Corneal Pain and Inflammation

The Effect of Medical Cannabis on Pain Level and Quality of Sleep among Rheumatology Clinic Outpatients

Involvement of Spinal CB1 Cannabinoid Receptors on the Antinociceptive Effect of Celecoxib in Rat Formalin Test

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Resources

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The Cannabinoids Δ⁸THC, CBD, and HU-308 Act via Distinct Receptors to Reduce Corneal Pain and Inflammation

The Cannabinoids Δ⁸THC, CBD, and HU-308 Act via Distinct Receptors to Reduce Corneal Pain and Inflammation