Involvement of CD44, a Molecule with a Thousand Faces, in Cancer Dissemination

Naor, David; Wallach-Dayan, Shulamit B.; Zahalka, Muayad A.; Sionov, Ronit Vogt

doi:10.1016/b978-012374178-3.10008-0

Cited by 73 publications

(92 citation statements)

References 56 publications

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“…As tumor cells get in contact with the ecm via several cell surface adhesion molecules such as cD44, integrins and cadherins it is likely that these proteins are also needed for metastatic processes (27). As cD44 obviously gets in contact with the ecm it is imaginable that there is a cD44 -dependent assembly and organization of the ecm, which might be useful to protect tumor cells from immune defence (28,29). pre-treatment of chondrocytes with an anti-cD44 antibody blocked their interaction with the ecm (30).…”

Section: Discussionmentioning

confidence: 99%

CD44 as a stem cell marker in head and neck squamous cell carcinoma

Faber

Barth²,

Hörmann³

et al. 2011

Oncol Rep

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Abstract. In the recent past, evidence is increasing indicating the existence of a subpopulation of resistant tumor cells in head and neck squamous cell carcinoma (Hnscc) that cannot be eradicated by established antineoplastic treatments. these cancer stem cells (cscs) have features of somatic stem cells such as selfrenewal, proliferation and differentiation. cD44 + cells in tumors of the head and neck are referred to as cscs of Hnscc. expression profiling of cD44 in 29 HNSCC tumors was performed by fluorescence microscopy. elIsA analysis was performed to detect concentration of soluble cD44 in the peripheral blood of 29 Hnscc patients and 11 healthy controls. expression of cD44 was determined in all Hnscc tissue samples (n=29). In all samples a surface staining pattern was found. the concentration of cD44 in the peripheral blood of HNSCC patients was significantly higher compared to a healthy control group (m Hnscc =13.5±0.5 ng/ ml; m cont =9.3±0.6 ng/ml; p=0.6x10 -12 ). the role of cD44 as a marker for cscs in Hnscc remains to be ascertained. Further experiments might reveal its role as a diagnostic and prognostic factor, and possibly as a therapeutic target.

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Section: Discussionmentioning

confidence: 99%

CD44 as a stem cell marker in head and neck squamous cell carcinoma

Faber

Barth²,

Hörmann³

et al. 2011

Oncol Rep

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show abstract

“…The cytoplasmic tail embodies 6 putative serine phosphorylation sites and provides a connection to the cytoskeleton and to the tyrosine kinase family [rev. by [2,4,5,12,13]. Recent experiments assume that the juxtamembrane region of the cytoplasmic tail runs parallel to the negatively charged inner membrane because of its mostly basic residues.…”

Section: Protein Structurementioning

confidence: 99%

CD44 in hematological neoplasias

2011

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“…CD44, a specific receptor for hyaluronic acid and adhesion/homing molecule (Naor et al, 2008;Jaggupilli and Elkord, 2012), is a multifunctional class I transmembrane glycoprotein expressed in almost all normal and cancer cells (Naor et al, 2008;Jaggupilli and Elkord, 2012). In several previous studies, CD44 individually or in combination with other putative CSC markers has been applied to isolate CSCs in various solid tumors including breast (Al-Hajj et al, 2003), prostate, pancreas (Immervoll et al, 2011), ovarian, colorectal (Wielenga et al, 1993;Woodman et al, 1996;Choi et al, 2009), head and neck (Satpute et al, 2013) and bladder cancers (Yang and Chang, 2008;Chan et al, 2009;Slomiany et al, 2009;Lee et al, 2010;Su et al, 2010;Jaggupilli and Elkord, 2012).…”

Section: Introductionmentioning

confidence: 99%