Involvement of catecholamine neurotransmission in the rat anterior cingulate in effort-related decision making.

Schweimer, Judith; Saft, Simone; Hauber, Wolfgang

doi:10.1037/0735-7044.119.6.1687

Cited by 90 publications

(59 citation statements)

References 22 publications

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“…IC 3 shows remarkable overlap with the network suggested to underlie ''stable maintenance of task mode and strategy'' found in a functional connectivity analysis (43). Based on animal studies, it has been suggested that both the OFC and pMFC code the cost and benefit of actions in terms of reward delay (OFC) and effort (pMFC) (6,44,45). Accordingly, the network reflected in IC 3 appears to be involved in evaluating task-related costs and maintaining effort.…”

Section: Resultsmentioning

confidence: 99%

Prediction of human errors by maladaptive changes in event-related brain networks

Eichele

Debener

Calhoun

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

430

393

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Humans engaged in monotonous tasks are susceptible to occasional errors that may lead to serious consequences, but little is known about brain activity patterns preceding errors. Using functional MRI and applying independent component analysis followed by deconvolution of hemodynamic responses, we studied error preceding brain activity on a trial-by-trial basis. We found a set of brain regions in which the temporal evolution of activation predicted performance errors. These maladaptive brain activity changes started to evolve Ϸ30 sec before the error. In particular, a coincident decrease of deactivation in default mode regions of the brain, together with a decline of activation in regions associated with maintaining task effort, raised the probability of future errors. Our findings provide insights into the brain network dynamics preceding human performance errors and suggest that monitoring of the identified precursor states may help in avoiding human errors in critical real-world situations.deconvolution ͉ performance monitoring ͉ default mode ͉ frontal lobe H uman behavior may be strongly determined by the ongoing intrinsic dynamics of regional brain networks (1-3). Although it is conceivable that patterns of brain activity preceding action execution are causally responsible for the behavioral outcome, previous research of human performance monitoring typically focused on brain activity evoked by and occurring after behavioral errors and the ensuing adaptive compensatory mechanisms (4-6). It is not known yet how far ahead in time the state of cortical brain networks impacts on behavioral performance; some EEG and functional MRI (fMRI) evidence exists suggesting that activity in the preceding trial foreshadows subsequent errors but not earlier than that (7-10). The present study investigated this question by means of a single-trial analysis of event-related independent components (IC) in fMRI data during a visual task requiring rapid responses.We analyzed patterns of evoked brain activity across trials that preceded erroneous behavior and may thus be instrumental in causing errors. Errors in this simple repetitive forced-choice task in a controlled setting may principally have two mutually nonexclusive causes: One source of errors consists simply of random failures to implement the correct behavior, which may be generated by momentary fluctuations in neural activity during stimulus processing and response selection in a given trial (1, 11). Although it is possible to make predictions about adaptive behavior in trials succeeding an error, it would be largely impossible in this condition to anticipate future errors from current brain states. Another possibility is that a proportion of errors may be caused by a systematic maladjustment in cognitive control systems that develops more slowly over time, and which thus affords a prediction about future behavior, in particular the likelihood of an erroneous response from analyzing trends in the history of activity across trials. Models of cognitive control propose a p...

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Section: Resultsmentioning

confidence: 99%

Prediction of human errors by maladaptive changes in event-related brain networks

Eichele

Debener

Calhoun

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

430

393

View full text Add to dashboard Cite

show abstract

“…Dopamine function, which has long been implicated in willingness to expend effort (Salamone, 2009;Salamone et al, 2007;Treadway et al, 2012b), may also act on these regions to affect effortful decision making (Schweimer and Hauber, 2006;Schweimer et al, 2005), and thus its contribution to cognitive effort is currently under study. The overlapping-yet-distinct effects observed in the present experiments suggest that regions not required for physical effort-based decision making, such as the prefrontal cortex, may in fact be necessary for decision making with cognitive effort costs (Schmidt et al, 2012), and the NAc' prevalence in the effort literature warrants future consideration of its involvement in choice on the rCET.…”

Section: Discussionmentioning

confidence: 99%

Dissociable Contributions of Anterior Cingulate Cortex and Basolateral Amygdala on a Rodent Cost/Benefit Decision-Making Task of Cognitive Effort

Hosking

Cocker

Winstanley

2014

Neuropsychopharmacol

117

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Personal success often requires the choice to expend greater effort for larger rewards, and deficits in such effortful decision making accompany a number of illnesses including depression, schizophrenia, and attention-deficit/hyperactivity disorder. Animal models have implicated brain regions such as the basolateral amygdala (BLA) and anterior cingulate cortex (ACC) in physical effort-based choice, but disentangling the unique contributions of these two regions has proven difficult, and effort demands in industrialized society are predominantly cognitive in nature. Here we utilize the rodent cognitive effort task (rCET), a modification of the five-choice serial reactiontime task, wherein animals can choose to expend greater visuospatial attention to obtain larger sucrose rewards. Temporary inactivation (via baclofen-muscimol) of BLA and ACC showed dissociable effects: BLA inactivation caused hard-working rats to 'slack off' and 'slacker' rats to work harder, whereas ACC inactivation caused all animals to reduce willingness to expend mental effort. Furthermore, BLA inactivation increased the time needed to make choices, whereas ACC inactivation increased motor impulsivity. These data illuminate unique contributions of BLA and ACC to effort-based decision making, and imply overlapping yet distinct circuitry for cognitive vs physical effort. Our understanding of effortful decision making may therefore require expanding our models beyond purely physical costs.

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“…Accordingly, local blockade of DA receptors, in particular the D 4 subtype, impairs both acquisition and extinction of a conditioned fear response (Pezze et al, 2003;Laviolette et al, 2005;Pfeiffer and Fendt, 2006). Similarly, different forms of decision making dependent on BLA-mPFC circuits are also impaired by depletion of DA or blockade of D 1 , D 2 , or D 4 receptors in the mPFC (Schweimer et al, 2005;Floresco and Magyar, 2006;Floresco and Ghods-Sharifi, 2007). These findings indicate that dopaminergic mediation of excitatory and inhibitory transmission in the BLA 3 mPFC pathway plays an important role in mediating emotional and cognitive processes governed by temporalfrontal lobe circuitry.…”

Section: Functional Implicationsmentioning

confidence: 99%

Dopaminergic Regulation of Inhibitory and Excitatory Transmission in the Basolateral Amygdala–Prefrontal Cortical Pathway

Floresco¹,

Tse²

2007

J. Neurosci.

191

149

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Projections from the basolateral amygdala (BLA) and dopamine (DA) input from the ventral tegmental area (VTA) converge in the medial prefrontal cortex (mPFC), forming a neural circuit implicated in certain cognitive and emotional processes. However, the role that DA plays in modulating activity in the BLA-mPFC pathway is unknown. The present study investigated the mechanisms by which DA modulates BLA-evoked changes in mPFC neural activity, using extracellular single-unit recordings in urethane-anesthetized rats.

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Involvement of catecholamine neurotransmission in the rat anterior cingulate in effort-related decision making.

Cited by 90 publications

References 22 publications

Prediction of human errors by maladaptive changes in event-related brain networks

Prediction of human errors by maladaptive changes in event-related brain networks

Dissociable Contributions of Anterior Cingulate Cortex and Basolateral Amygdala on a Rodent Cost/Benefit Decision-Making Task of Cognitive Effort

Dopaminergic Regulation of Inhibitory and Excitatory Transmission in the Basolateral Amygdala–Prefrontal Cortical Pathway

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