Involvement of C‐X‐C chemokine receptor type 4 signaling in the efficiency of intercellular transmission of human T‐lymphotropic virus type I

Nakamura, Tatsufumi; Satoh, Katsuya; Fukushima, Naomi

doi:10.1111/cen3.12278

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…Rap1, a small GTPase that functions in a complex with adaptor molecules, such as RAPL, talin1, and kindlin-3, facilitates the inside-out signaling for integrin signaling, leading to increased adhesion to integrin ligands [ 51 , 52 ]. Activation of Rap1 through C-X-C chemokine receptor type 4 signaling was observed in the analysis of an HTLV-1-infected T cell line derived from a HAM/TSP patient [ 53 ].…”

Section: The Role Of Small Gtpase Activation Leading To the Heightene...mentioning

confidence: 99%

HAM/TSP Pathogenesis: The Transmigration Activity of HTLV-1-Infected T Cells into Tissues

Nakamura

2023

Pathogens

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Slowly progressive spastic paraparesis with bladder dysfunction, the main clinical feature of human T-cell leukemia virus-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), is induced by chronic inflammation in the spinal cord, mainly the lower thoracic cord. A long-standing bystander mechanism, such as the destruction of surrounding tissues by inflammatory cytokines, etc., induced under the interaction between infiltrated HTLV-1-infected CD4+ T cells and HTLV-1-specific CD8+ cytotoxic T cells, has been considered implicated for the induction of chronic inflammation. As this bystander mechanism is triggered conceivably by the transmigration of HTLV-1-infected CD4+ T cells to the spinal cord, heightened transmigrating activity of HTLV-1-infected CD4+ T cells to the spinal cord might play a crucial role as the first responder in the development of HAM/TSP. This review evaluated the functions of HTLV-1-infected CD4+ T cells in HAM/TSP patients as the prerequisite for the acquisition of the activity such as adhesion molecule expression changes, small GTPases activation, and expression of mediators involved in basement membrane disruption. The findings suggest that HTLV-1-infected CD4+ T cells in HAM/TSP patients have enough potential to facilitate transmigration into the tissues. Future HAM/TSP research should clarify the molecular mechanisms leading to the establishment of HTLV-1-infected CD4+ T cells as the first responder in HAM/TSP patients. In addition, a regimen with an inhibitory activity against the transmigration of HTLV-1-infected CD4+ T cells into the spinal cord might be recommended as one of the therapeutic strategies against HAM/TSP patients.

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Section: The Role Of Small Gtpase Activation Leading To the Heightene...mentioning

confidence: 99%

HAM/TSP Pathogenesis: The Transmigration Activity of HTLV-1-Infected T Cells into Tissues

Nakamura

2023

Pathogens

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Role of Integrin Signaling Activation on the Development of Human T Cell Leukemia Virus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis: Its Relationship to HTLV-1-Infected CD4⁺T Cell Transmigrating Activity into the Tissues

Nakamura

Satoh

Nakamura

et al. 2018

AIDS Research and Human Retroviruses

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The main clinical feature of human T cell leukemia virus-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is slowly progressive spastic paraparesis with bladder dysfunction. HAM/TSP is induced by chronic inflammation in the spinal cord, mainly the lower thoracic cord. A long-standing bystander mechanism, such as the destruction of surrounding tissues by the interaction between infiltrated Th1-like, HTLV-1-infected CD4 T cells and HTLV-1-specific CD8 cytotoxic T cells (CTL), is probably critical for the induction of chronic inflammation. Although the HTLV-1-infected CD4 T cells in HAM/TSP appear to play a crucial role in the initial pathogenesis of HAM/TSP, the exact mechanisms of how these cells acquire their function as the first responders in the pathogenesis of HAM/TSP still remain unresolved. Herein, we propose the importance of the activation of both outside-in signals from integrin signaling and inside-out signals for integrin signaling in the HTLV-1-infected CD4 T cells of HAM/TSP patients.

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Involvement of C‐X‐C chemokine receptor type 4 signaling in the efficiency of intercellular transmission of human T‐lymphotropic virus type I

Cited by 2 publications

References 18 publications

HAM/TSP Pathogenesis: The Transmigration Activity of HTLV-1-Infected T Cells into Tissues

HAM/TSP Pathogenesis: The Transmigration Activity of HTLV-1-Infected T Cells into Tissues

Role of Integrin Signaling Activation on the Development of Human T Cell Leukemia Virus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis: Its Relationship to HTLV-1-Infected CD4⁺T Cell Transmigrating Activity into the Tissues

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Involvement of C‐X‐C chemokine receptor type 4 signaling in the efficiency of intercellular transmission of human T‐lymphotropic virus type I

Cited by 2 publications

References 18 publications

HAM/TSP Pathogenesis: The Transmigration Activity of HTLV-1-Infected T Cells into Tissues

HAM/TSP Pathogenesis: The Transmigration Activity of HTLV-1-Infected T Cells into Tissues

Role of Integrin Signaling Activation on the Development of Human T Cell Leukemia Virus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis: Its Relationship to HTLV-1-Infected CD4+T Cell Transmigrating Activity into the Tissues

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Role of Integrin Signaling Activation on the Development of Human T Cell Leukemia Virus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis: Its Relationship to HTLV-1-Infected CD4⁺T Cell Transmigrating Activity into the Tissues