Involvement of brain dopamine in prolactin secretion induced by a synthetic Met5-enkephalin analogue in rats.

Matsushita, Norio; Kato, Yuzuru; Katakami, Hideki; Shimatsu, Akira; Imura, Hiroo

doi:10.1507/endocrj1954.29.277

Endocrinol Japon

1982

DOI: 10.1507/endocrj1954.29.277

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Involvement of brain dopamine in prolactin secretion induced by a synthetic Met5-enkephalin analogue in rats.

Norio Matsushita

Yuzuru Kato

Hideki Katakami

et al.

Abstract: Abstract

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Cited by 8 publications

(1 citation statement)

References 37 publications

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“…9 pophyseal portal blood (8). Opioid peptides and dopamine antagonists stimulate PRL release by possibly inhibiting hypothalamic dopamine release (9)(10)(11)(12)(13)(14) and by blocking the dopamine action at the pituitary (15,16), respectively.…”

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confidence: 99%

Central Inhibitory Action of TRH on Prolactin Secretion in the Rat

Ohta

Kato

Matsushita

et al. 1985

Experimental Biology and Medicine

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Intravenous (iv) injection of FK33-824 ( [D-Ala2, MePhe4, Met-(0)5-ol]-enkephalin, 8 and 16 nmole/l00 g body wt), a potent Met5-enkephalin analog, and domperidone (1.2, 2.4, and 24 nmole/100 g body wt), a dopamine antagonist, resulted in a dose-related increase in plasma prolactin (PRL) levels in urethane-anesthetized male rats. PRL release induced by FK33-824 (16 nmole/100 g body wt, iv) was inhibited by intraventricular (icv) injection of TRH (0.6 nmole/rat). DN-14 17 (y-butyrolactone-y-carbonyl-histidyl-prolinamide citrate, 0.6 nmole/rat, icv), a TRH analog, also blunted PRL release induced by FK33-824. PRL release induced by a smaller dose of domperidone (1.2 nmole/100 g body wt, iv) was blunted by TRH and DN-1417, whereas both peptides failed to suppress elevated PRL levels induced by larger doses of domperidone. These results suggest that TRH not only stimulates PRL secretion by acting directly at the pituitary, but has an inhibitory action on PRL release through activation Of the central dopaminergic mechanism.

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Central Inhibitory Action of TRH on Prolactin Secretion in the Rat

Ohta

Kato

Matsushita

et al. 1985

Experimental Biology and Medicine

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From macroprolactinoma to concomitant ACTH-PRL hypersecretion with Cushing’s disease

Barausse

Attanasio

Dallabonzana

et al. 2000

J Endocrinol Invest

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Multiple pituitary hormone hypersecretions have been already described, but the combination of PRL and ACTH excess is rare. This report deals with a 42-yr-old woman affected by macroprolactinoma (PRL 12,720 microg/l, huge tumor with extrasellar extension at imaging). After one year on dopaminergic treatment causing PRL normalization and tumor shrinkage, she developed hypercortisolism (UFC 1,000 microg/24 h, ACTH 200 ng/l). Cushing's disease was diagnosed. After neurosurgery (at immunocytochemistry mixed ACTH-PRL adenoma was shown) hypercortisolism remitted, whereas pathological hyperprolactinemia with tumor remnant in cavernous sinus persisted and hypopituitarism developed. The patient reported seems atypical for the following reasons: 1) the concomitant PRL and ACTH hypersecretions; 2) the clinical presentation with hypercortisolism following hyperprolactinemia; 3) the surgical cure of hypercortisolism with persisting hyperprolactinemia.

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The hypothalamic anterior pituitary relationships and their tumors

VanGilder

1988

Surgical Neurology

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Involvement of brain dopamine in prolactin secretion induced by a synthetic Met5-enkephalin analogue in rats.

Abstract: Abstract

Cited by 8 publications

References 37 publications

Central Inhibitory Action of TRH on Prolactin Secretion in the Rat

Central Inhibitory Action of TRH on Prolactin Secretion in the Rat

From macroprolactinoma to concomitant ACTH-PRL hypersecretion with Cushing’s disease

The hypothalamic anterior pituitary relationships and their tumors

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