Involvement of bombesin in spermine-induced corticosterone secretion and intestinal maturation in suckling rats

Kaouass, Mohammadi; Deloyer, Patricia; Dandrifosse, Guy

doi:10.1677/joe.0.1530429

Cited by 10 publications

(9 citation statements)

References 22 publications

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“…The nervous system target has not been identified, but we know that spermine can be transformed into γ-aminobutyric acid (Laschet et al 1998) and can act directly on the γ-aminobutyric acid receptor. Results also suggest that neurosecretion of bombesin is affected (Kaouass et al 1997a). As a result, intestinal motility would be decreased, as observed in vitro in rat pups and reported in adult animals.…”

Section: Information From Studies Performed Using Sucking Ratssupporting

confidence: 72%

“…In the rat the most recent findings in the field (for example, see Dufour et al 1988;Georges et al 1990;Dandrifosse et al 1991;Romain et al 1992Romain et al , 1998Wery et al 1992Wery et al , 1996aButs et al 1993Buts et al , 1994Kaouass et al 1993Kaouass et al , 1994Kaouass et al , 1996Kaouass et al , 1997aDeloyer et al 1996;Peulen et al 1997Peulen et al , 1998aLaschet et al 1998) have led to a working hypothesis explaining the effect of spermine on the maturation of the digestive tract, especially at the level of the intestine (Luk et al 1980;Dufour et al 1988;Georges et al 1990;Buts et al 1993;Dandrifosse et al 1999). In this organ two phases characterize the effect of spermine (Wery et al 1992(Wery et al , 1996aWery & Dandrifosse, 1993;Kaouass et al 1996;Peulen et al 1998b;Dandrifosse et al 1999;; desquamation of the intestinal epithelium is followed by a hormonal cascade.…”

Section: Information From Studies Performed Using Sucking Ratsmentioning

confidence: 99%

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Are milk polyamines preventive agents against food allergy?

et al. 2000

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Insufficient polyamine intake could play a role in the induction of sensitization to dietary allergens. This proposal is based essentially on investigations made in sucking rats and in children. In sucking rats it has been established that oral administration of spermine can induce all the modifications occurring in the digestive tract at weaning. In the intestine events occur in two phases. The early event consists of desquamation of the epithelium resulting from an activation of apoptosis. The late event appears to involve an hormonal cascade in which adrenocorticotropic hormone, cytokines, bombesin and corticosterone are included. Observations in human subjects show that: (1) the spermine and spermidine concentrations are generally lower in infant formulas than in human breast milk. Mothers seem consistently to have relatively high or relatively low concentrations of spermine and spermidine in their milk. These individual variations may be due to diet, lifestyle or genetic background; (2) the probability of developing allergy can reach 80 % if the mean spermine concentration in the milk is lower than 2 nmol/ml milk. It is approximately 0 % if the mean spermine concentration is higher than 13 nmol/ml milk; (3) preliminary results show that the intestinal permeability to macromolecules differs in premature babies when they are fed on breast milk compared with infant formulas (J Senterre, J Rigo, G Forget, G Dandrifosse and N Romain, unpublished results). This difference does not seem to be present when powdered milk is supplemented with polyamines at the concentration found in breast milk; (4) spermine increases proliferation and differentiation of lymphocytes isolated from the tonsils of children.

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Section: Information From Studies Performed Using Sucking Ratssupporting

confidence: 72%

Section: Information From Studies Performed Using Sucking Ratsmentioning

confidence: 99%

Are milk polyamines preventive agents against food allergy?

et al. 2000

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“…On the one hand, the results support an HPA‐independent control mechanism for this enzyme (Freund et al 1990, 1991; Krasinski et al 1994). On the other hand, the control of lactase SA may be influenced by interleukin‐2 (Peulen & Dandrifosse, 2004) or gastrointestinal (GI) hormones such as bombesin (Kaouass et al 1997 a ). These GI hormones or interleukin could be secreted without interruption during the spermine‐induced maturation process.…”

Section: Discussionmentioning

confidence: 99%

Intestinal effects of long‐lasting spermine ingestion by suckling rats

Deloyer

Peulen

Dandrifosse

2005

Experimental Physiology

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Spermine ingestion induces the precocious maturation of the small intestine in suckling rats. Previous observations suggest that spermine-induced intestinal maturation is a two-step phenomenon. The first step is the elimination of immature enterocytes (4-10 h post spermine ingestion) and the second step is the replacement of previous immature cells by adult-type enterocytes (2-3 days post initial spermine administration). The spermine-induced maturation is reversible when spermine administration is stopped. This work was undertaken in order to check whether the extension of polyamine administration (for 3-7 days) after the appearance of spermine-induced maturation can retain the mature state of the small intestine. Our results indicate that extension of spermine administration does not prevent some parameters (sucrase and maltase specific activities) reverting to a typical 'immature' value while others remain at a typical 'mature' level (mucosal weight and lactase specific activity). Our results show that there are at least two different mechanisms in required for the control of spermine-induced maturation of the small intestine.

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“…However, we found in this and in a previous study (18) that intestinal wet weight does not decrease until after 1 wk after adrenalectomy. Other studies have also suggested that adrenalectomy has no short-term effect on intestinal weight of suckling rats (42).…”

Section: Asbt Development Requires Thyroxinementioning

confidence: 98%

Ontogenetic Development of Rat Intestinal Bile Acid Transport Requires Thyroxine But Not Corticosterone

2004

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Absorption of bile acids by the distal ileum is an essential component of the enterohepatic circulation. In neonatal rats, the appearance of the apical sodium-dependent bile acid transporter (ASBT) at 17 d of age coincides with increases in serum corticosterone and thyroxine. We tested the hypothesis that these hormones modulate ASBT expression during ileal development. Taurocholate uptake into the isolated ileum of normal 20-d-old pups exhibited saturable (K m ϭ 0.52 mM, J max ϭ 0.34 pmol mg/min) and nonsaturable (K diff ϭ 0.015 min Ϫ1 ) components and was two to five times greater than uptake in the proximal intestine. Hypothyroid or euthyroid pups received daily thyroxine injections starting at 6 d of age. At 12 d of age, serum concentrations of thyroxine, ileal abundance of ASBT mRNA, and ileal rates of taurocholate uptake were low in hypothyroid pups that received an injection of vehicle (HTϪ) or thyroxine (HTϩ) and in euthyroid pups that received an injection of vehicle (ETϪ) or thyroxine (ETϩ). At 20 and 26 d, ileal ASBT mRNA abundance and taurocholate uptake rate remained low in HTϪ pups but increased dramatically in ETϪ and ETϩ pups, paralleling the increase in serum thyroxine. Restoration of normal plasma thyroxine in HTϪ pups by thyroxine injections (HTϩ) restored normal ASBT development. Sodium-glucose co-transporter activity and mRNA expression were independent of serum thyroxine levels. Corticosterone levels were significantly lower in pups that were adrenalectomized at 10 d of age. ASBT mRNA abundance and taurocholate uptake rate increased markedly with age but were the same in adrenalectomized, sham-operated, and nonoperated pups. Hence, endogenous thyroxine but not corticosterone regulates the developmentally timed appearance of ASBT. Bile acids expelled from the gallbladder into the intestinal lumen emulsify dietary lipids to aid digestion, then form micelles with the products of lipid digestion to facilitate absorption. Synthesis of bile acids by the liver is insufficient to meet physiologic needs, and bile acids are recycled in a process that involves their absorption from the intestinal lumen back into the circulation and eventual resecretion from the liver. Bile acids are absorbed passively and in modest amounts in the jejunum (1) but are absorbed actively and in greater amounts in the distal ileum by the apical sodium-dependent transporter (ASBT) located at the brush border membrane of the enterocyte (2). It is not clear when active bile acid absorption begins during ontogenetic development of the small intestine. Sodium-dependent uptake of the bile acid taurocholate has been observed in the small intestine of an 8-mo-old child but not in that of a fetus or a neonate (3). Because reabsorption in the distal small intestine of neonates is inefficient or absent,~10 -20% of fat intake in the formula-fed newborn is thought to be malabsorbed, even though the rate of bile acid synthesis in the neonatal liver is markedly higher than that of older age groups. In rat pups, ASBT mRNA, protein, and ac...

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Involvement of bombesin in spermine-induced corticosterone secretion and intestinal maturation in suckling rats

Cited by 10 publications

References 22 publications

Are milk polyamines preventive agents against food allergy?

Are milk polyamines preventive agents against food allergy?

Intestinal effects of long‐lasting spermine ingestion by suckling rats

Ontogenetic Development of Rat Intestinal Bile Acid Transport Requires Thyroxine But Not Corticosterone

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