“…[35] After these seminal studies, several groups described 4-substituted isoxazoline rearrangements under thermal conditions and found that the efficiency of formation and the stability of 2-acylaziridines depend significantly on the nature of their substituents (Scheme 4). [38][39][40][41][42][43] Thermolysis of 2-acylaziridines (sometimes under the conditions of their formation) can take place through azomethine ylide formation to produce 4-oxazolines (see Scheme 2), pyrroles, enamines or carbonyl compounds as a myriad of side products. [19,20] The isomerization of 2-acylaziridines into azomethine ylides can be retarded by various factors such as the steric hindrance or electronic properties of their N-substituents.…”