Involvement of ATP‐sensitive K+ channels in the peripheral antinociceptive effect induced by ketamine

Romero, Thiago Roberto Lima; Duarte, I.D.G.

doi:10.1111/vaa.12024

Cited by 19 publications

(11 citation statements)

References 37 publications

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“…In contrast to the present results, we have recently shown that in somatic inflammatory model of pain, NO plays a role in the mechanism of action of magnesium (Srebro et al, 2014). Other researchers have shown that activation of ATP-sensitive K + channel pathway has a role in ketamine-induced peripheral antinociceptive effects in the prostaglandin E2-induced hyperalgesia in the rat paw (Romero & Duarte, 2013). Also, Bulutcu et al (2002) demonstrated the contribution of NO-cGMP pathway to the antinociceptive effects of ketamine in the acetic acid-induced writhing test.…”

Section: Discussioncontrasting

confidence: 55%

The antinociceptive effects of magnesium sulfate and MK-801 in visceral inflammatory pain model: The role of NO/cGMP/K⁺ATP pathway

Vučković

Srebro

Vujović

et al. 2015

Pharmaceutical Biology

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Context: Magnesium and MK-801 (dizocilpine), antagonists of N-methyl-D-aspartate receptors, are involved in the processing of pain. Objective: This study determines whether magnesium sulfate (MS) and MK-801 affects visceral inflammatory pain and determines a possible mechanism of action. Materials and methods: Analgesic activity was assessed using the acetic acid-induced writhing test in rats. MS (1-45 mg/kg) or MK-801 (0.005-0.03 mg/kg) was administrated subcutaneously (s.c.). To assess possible mechanisms of action, we examined the effects of L-NAME (10 mg/kg, intraperitoneal), methylene blue (0.5 mg/kg, s.c.), and glibenclamide (3 mg/kg, s.c.) on the effect of MS or MK-801. Results: MS and MK-801 showed biphasic and linear dose-response pattern, respectively. MS reduces the number of writhing on the dose of 1, 5, and 15 mg/kg by 60, 50, and 78%, respectively, while it has no effects on the doses of 30 and 45 mg/kg. MK-801 (0.005-0.03 mg/kg) showed decrease in the number of writhing by 33-79%. The mean effective doses of MS and MK-801 were 6.6 (first phase) and 0.009 mg/kg, respectively. Both drugs did not impair the rotarod performance. L-NAME, methylene blue, and glybenclamide reduced the effect of MK-801 by 100, 43, and 64%, respectively, but not the effect of MS. Conclusions:The results suggest that MS and MK-801 may be useful analgesics in the management of visceral inflammatory pain, at doses that do not induce motor impairment. The modulation of NO/cGMP/K+ATP pathway plays an important role in the antinociceptive mechanism of MK-801, but does not contribute to the antinociceptive effect of MS.

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Section: Discussioncontrasting

confidence: 55%

The antinociceptive effects of magnesium sulfate and MK-801 in visceral inflammatory pain model: The role of NO/cGMP/K⁺ATP pathway

Vučković

Srebro

Vujović

et al. 2015

Pharmaceutical Biology

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“…The results of the present study are consistent with previously reported results. 12 This effect has been reported at doses lower than ours -7.5 mg/kg bw and 10 mg/kg bw single dose, as well as in a model of hyperalgesia caused by intraplantarly injected prostaglandin E2.…”

Section: Anti-nociceptive Effect Of Ketamine On Acute Painmentioning

confidence: 57%

Study of antinociceptive effect of ketamine in acute and neuropathic pain models in rats

Doncheva¹,

Vasileva²,

Saracheva³

et al. 2018

Adv Clin Exp Med

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Background. Glutamate N-methyl-D-aspartate (NMDA) receptors are known for their importance in the perseverance of chronic neuropathic pain. Ketamine, an intravenous anesthetic agent, is a non-competitive blocker of NMDA receptors. Applied in anesthetic doses, ketamine has anti-nociceptive effects in various animal pain models. Objectives. The objective of this study was to investigate the anti-nociceptive effect of ketamine in acute and neuropathic pain models in rats. Material and methods. To study the anti-nociceptive effect of ketamine on acute pain, 40 Wistar rats were divided into 5 groups (n = 8): control, positive control group and 3 experimental groups treated intraperitoneally (ip.) with 30 mg/kg bw, 40 mg/kg bw and 50 mg/kg bw ketamine, respectively. The anti-nociceptive effect was evaluated in hot plate, analgesy-meter and formalin tests. The model of neuropathic pain was induced by left sciatic nerve ligation. Twenty-four Wistar rats were divided into 3 groups (n = 8): sham-control group, model group and ketamine-treated group subsequently tested in hot plate and analgesy-meter tests. Results. In the hot plate test, the rats treated with ketamine presented increased reaction latency at the 120 th min and 180 th min compared to the controls. In the analgesy-meter test, ketamine produced an antinociceptive effect at the 60 th min compared to the controls. In the formalin test, the paw licking time across the early phase of testing was reduced in the rats treated with the 2 higher doses of ketamine. In a neuropathic pain model, ketamine increased the reaction latency at the 120 th min and 180 th min compared with the model group in the hot plate test. In the analgesy-meter test, in the ketamine-treated animals the paw withdrawal threshold increased at the 60 th min compared with the model group. Conclusions. Our results suggest that ketamine produces peripheral anti-nociceptive effect in an acute pain model. Also, it relieves thermal and mechanical allodynia after 14 days of treatment in a neuropathic pain model.

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“…By inhibiting these receptors, the neurotransmitter glutamate is unable to attach to the receptor thus causing inhibition of calcium ion flow into the presynaptic neuron, thus inhibiting nociception. Ketamine may also produce peripheral analgesia by blocking neuronal sodium and potassium channels (similar to local anaesthetic agents, such as lidocaine or mepivacaine) thereby obstructing nerve transmission .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of ketamine hydrochloride administered as a basilar sesamoid nerve block in alleviating foot pain in horses caused by natural disease

Schumacher

DeGraves

Cesar

et al. 2013

Equine Veterinary Journal

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Involvement of ATP‐sensitive K+ channels in the peripheral antinociceptive effect induced by ketamine

Cited by 19 publications

References 37 publications

The antinociceptive effects of magnesium sulfate and MK-801 in visceral inflammatory pain model: The role of NO/cGMP/K⁺ATP pathway

The antinociceptive effects of magnesium sulfate and MK-801 in visceral inflammatory pain model: The role of NO/cGMP/K⁺ATP pathway

Study of antinociceptive effect of ketamine in acute and neuropathic pain models in rats

Efficacy of ketamine hydrochloride administered as a basilar sesamoid nerve block in alleviating foot pain in horses caused by natural disease

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Involvement of ATP‐sensitive K+ channels in the peripheral antinociceptive effect induced by ketamine

Cited by 19 publications

References 37 publications

The antinociceptive effects of magnesium sulfate and MK-801 in visceral inflammatory pain model: The role of NO/cGMP/K+ATP pathway

The antinociceptive effects of magnesium sulfate and MK-801 in visceral inflammatory pain model: The role of NO/cGMP/K+ATP pathway

Study of antinociceptive effect of ketamine in acute and neuropathic pain models in rats

Efficacy of ketamine hydrochloride administered as a basilar sesamoid nerve block in alleviating foot pain in horses caused by natural disease

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Resources

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The antinociceptive effects of magnesium sulfate and MK-801 in visceral inflammatory pain model: The role of NO/cGMP/K⁺ATP pathway

The antinociceptive effects of magnesium sulfate and MK-801 in visceral inflammatory pain model: The role of NO/cGMP/K⁺ATP pathway