Involvement of Ath3 in CNTF-mediated differentiation of the late retinal progenitors

Bhattacharya, Sumitra; Dooley, Constance M.; Soto, Frank; Madson, Justin; Das, Ani V.; Ahmad, Iqbal

doi:10.1016/j.mcn.2004.05.004

Cited by 17 publications

(19 citation statements)

References 42 publications

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“…Concomitant to suppression of rod differentiation, CNTF/LIF promotes the expression of several bipolar cell markers in the postnatal retina (Ezzeddine et al 1997; Schulz-Key et al 2002; Bhattacharya et al 2004; Zahir et al 2005). By tracking cell birthdates and analyzing proportions of different cell markers, Ezzeddine et al (1997) concluded that the bipolar marker-positive cells are derived from cells that would normally give rise to rod photoreceptors.…”

Section: 2 Effects Of Cntf/lif On Photoreceptor and Bipolar Neuronmentioning

confidence: 99%

Function and Mechanism of CNTF/LIF Signaling in Retinogenesis

Rhee

Yang

2009

Retinal Degenerative Diseases

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Section: 2 Effects Of Cntf/lif On Photoreceptor and Bipolar Neuronmentioning

confidence: 99%

Function and Mechanism of CNTF/LIF Signaling in Retinogenesis

Rhee

Yang

2009

Retinal Degenerative Diseases

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“…In rodents, CNTF inhibits rod photoreceptor differentiation as indicated by the suppression of rhodopsin expression (Ezzeddine et al, 1997;Neophytou et al, 1997;Schulz-Key et al 2002). This inhibitory effect on rod differentiation is accompanied by an increase of bipolar cell marker expression in the rat retina (Ezzeddine et al, 1997;Bhattacharya et al, 2004). In contrast to rodents, CNTF promotes the differentiation of a subclass of cone photoreceptors in the developing chicken retina (Fuhrmann et al, 1995;Kirsch et al, 1996;Xie and Adler, 2000).…”

Section: Introductionmentioning

confidence: 99%

Cytokine-Induced Activation of Signal Transducer and Activator of Transcription in Photoreceptor Precursors Regulates Rod Differentiation in the Developing Mouse Retina

Rhee¹,

Goureau²,

Chen³

et al. 2004

J. Neurosci.

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has no effect on rod photoreceptor differentiation in vitro. Furthermore, disrupting the function of epidermal growth factor (EGF) receptors, which modulate rod development in vivo, indicates that the EGF family of ligands does not mediate the inhibitory effect of cytokine on rod differentiation. These results demonstrate that cytokine signal transduction is dynamic and heterogeneous in the developing retina, and that endogenous ligand-induced STAT activation in retinal progenitor and/or photoreceptor precursor cells plays an important role in regulating photoreceptor development.

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“…In both rat and mouse retinas, CNTF as well as leukemia inhibitory factor (LIF), another CNTF-like cytokine, strongly inhibit rod photoreceptor cell differentiation [Kirsch et al, 1996;Ezzeddine et al, 1997;Neophytou et al, 1997;SchulzKey et al, 2002]; whereas in the chicken retina, CNTF promotes development of a subset of cone photoreceptors [Fuhrmann et al, 1995;Kirsch et al, 1996;Xie and Adler, 2000]. Furthermore, CNTF enhances the expression of bipolar neuron markers in the rat retinal culture [Ezzeddine et al, 1997;Schulz-Key et al, 2002;Bhattacharya et al, 2004]. Here, we report that in addition to its effects on photoreceptor and bipolar cell differentiation, CNTF also promotes Müller glia genesis from the postnatal retinal progenitor pool.…”

Section: Introductionmentioning

confidence: 99%

Ciliary Neurotrophic Factor Promotes Müller Glia Differentiation from the Postnatal Retinal Progenitor Pool

2004

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Ciliary neurotrophic factor (CNTF) exhibits multiple biological effects during vertebrate retinal development, including regulating the differentiation of photoreceptor cells and promoting the survival and axonal growth of ganglion cells. We report here that in addition to affecting the differentiation of retinal neurons, CNTF also promotes Müller glia genesis in the postnatal mouse retina. In both retinal monolayer and explant cultures, CNTF increases the number of progenitor cells adopting the Müller cell fate. Exogenous CNTF induces phosphorylation of signal transducers and activators of transcription (STAT)3 and extracellular signal-regulated kinase (ERK) among neonatal progenitor cells and newborn Müller cells. In addition, increased levels of endogenous STAT3 and ERK phosphorylation have been observed at around postnatal day 5, coinciding with the peak of Müller glia genesis. Perturbation of STAT and ERK signaling using protein kinase inhibitors and a dominant-negative STAT3 mutant demonstrates that both CNTF-induced STAT and ERK activation are involved in promoting Müller cell production. Moreover, absorbing epidermal growth factor (EGF) signals with a neutralizing antibody did not affect CNTF-induced Müller glial genesis, indicating that the effect of CNTF is not mediated by the known Müller-enhancing activity of EGF. Together, these results support a novel function of CNTF-like cytokines in retinal gliogenesis.

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Involvement of Ath3 in CNTF-mediated differentiation of the late retinal progenitors

Cited by 17 publications

References 42 publications

Function and Mechanism of CNTF/LIF Signaling in Retinogenesis

Function and Mechanism of CNTF/LIF Signaling in Retinogenesis

Cytokine-Induced Activation of Signal Transducer and Activator of Transcription in Photoreceptor Precursors Regulates Rod Differentiation in the Developing Mouse Retina

Ciliary Neurotrophic Factor Promotes Müller Glia Differentiation from the Postnatal Retinal Progenitor Pool

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