Involvement of arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability

Majumder, Samarpan; Liu, Yuanbo; Ford, O. Harris; Mohler, James L.; Whang, Young E.

doi:10.1002/pros.20438

Cited by 129 publications

(103 citation statements)

References 37 publications

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“…These studies suggest that increased expression of PRMT5 is part of the mechanism by which cells become transformed. Similarly, PRMT4 has also been shown to be overexpressed in primary prostate cancer, and reducing its expression in the LNCaP prostate cancer cell line inhibited cell growth and proliferation (Majumder et al, 2006). These findings indicate that alteration of normal histone methylation patterns is associated with cancer in humans and that histone methyltransferases should be considered as good candidates to target in cancer therapy.…”

Section: Regulation Of Prmt Activity and Its Role In Cancermentioning

confidence: 87%

Interplay between chromatin remodelers and protein arginine methyltransferases

Pal

Sif

2007

Journal Cellular Physiology

136

122

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Chromatin modifying enzymes have emerged as key regulators of all DNA based processes, which control cell growth, development, and differentiation. Recently, it has become clear that different chromatin remodeling and histone-modifying activities are involved in transcriptional activation and repression. Among the enzymes involved in regulating chromatin structure is the family of protein arginine methyltransferases (PRMTs) that specializes in methylating both histones as well as key cellular proteins. There are eleven different PRMT genes (PRMT1-11) whose biological function remains under explored. PRMTs regulate various cellular processes such as DNA repair and transcription, RNA processing, signal transduction, and nucleo-cytoplasmic localization. Like histone lysine methylation, methylation of histone arginine residues can either induce or inhibit transcription depending on the residue being modified and the type of methylation being introduced. In this review, we will focus on the latest findings and biological roles of ATP-dependent chromatin remodeling complexes and PRMT enzymes, and how their aberrant expression is linked to cancer.

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Section: Regulation Of Prmt Activity and Its Role In Cancermentioning

confidence: 87%

Interplay between chromatin remodelers and protein arginine methyltransferases

Pal

Sif

2007

Journal Cellular Physiology

136

122

View full text Add to dashboard Cite

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“…For example, the fact that PRMT1 and CARM1 can act as coactivators of nuclear receptors makes them likely candidates to be overexpressed in hormone-dependent cancers, including breast cancer (2). Indeed, it has been found that CARM1 overexpression correlates with androgen independence in human prostate carcinomas (73,74). It has also been observed that increased methylation of a PRMT6 substrate correlated with breast tumors of higher metastatic potential (75,76).…”

Section: Complex Genomic Structure At the 5ј-end Of The Prmt1 Gene Lementioning

confidence: 99%

Alternative Splicing Yields Protein Arginine Methyltransferase 1 Isoforms with Distinct Activity, Substrate Specificity, and Subcellular Localization

Goulet

Gauvin

Boisvenue

et al. 2007

Journal of Biological Chemistry

159

194

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PRMT1 is the predominant member of a family of protein arginine methyltransferases (PRMTs) that have been implicated in various cellular processes, including transcription, RNA processing, and signal transduction. It was previously reported that the human PRMT1 pre-mRNA was alternatively spliced to yield three isoforms with distinct N-terminal sequences. Close inspection of the genomic organization in the 5-end of the PRMT1 gene revealed that it can produce up to seven protein isoforms, all varying in their N-terminal domain. A detailed biochemical characterization of these variants revealed that unique N-terminal sequences can influence catalytic activity as well as substrate specificity. In addition, our results uncovered the presence of a functional nuclear export sequence in PRMT1v2. Finally, we find that the relative balance of PRMT1 isoforms is altered in breast cancer.

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“…18 The Coactivator Associated Arginine Methyl Transferase (CARM1) was shown to mediate histone H3 methylation at androgen-regulated enhancer elements in response to androgenic stimuli. 19 Histone methylation of AR target sequences can play significant roles in the dynamics of AR binding to cognate sequences. Interestingly, it was shown that bicalutamide, an AR antagonist, can facilitate histone methylation.…”

Section: Ar and Chromatinmentioning

confidence: 99%

Androgen receptor and prostate cancer

Richter

Srivastava

Dobi

2007

Prostate Cancer Prostatic Dis

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Since the original observations of Huggins and Hodges that prostate cancers are androgen dependent, androgen ablation therapy has been the gold standard for the treatment of advanced prostate cancer (CaP). Androgen receptor (AR) is believed to play critical roles in the development and progression of CaP. Treatment for neoadjuvant, adjuvant and recurrent disease all center on the regulation and manipulation of the androgen pathway, in which AR plays an integral role. Recent discoveries that frequent overexpression of ETS-related proto-oncogenes may be driven by AR as a consequence of common genomic rearrangements can hold the key towards the understanding of early phases of prostate cancer. Furthermore, AR function evolves as the cell changes towards a clinically androgen depletion independent state. Comprehension of AR function, regulation and abnormalities are increasingly refined towards the understanding of the role of AR in CaP, and in therapeutic applications. Development of future therapy for CaP will be aided by improving the knowledge of dysfunctions of AR and its network in prostate cancer. This review focuses salient features of AR and on the recent advances addressing AR dysfunctions in prostate cancer.

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Involvement of arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability

Abstract: CARM1 is essential for AR function and may play a role in prostate cancer progression. CARM1 may represent a novel therapeutic target in prostate cancer.

Cited by 129 publications

References 37 publications

Interplay between chromatin remodelers and protein arginine methyltransferases

Interplay between chromatin remodelers and protein arginine methyltransferases

Alternative Splicing Yields Protein Arginine Methyltransferase 1 Isoforms with Distinct Activity, Substrate Specificity, and Subcellular Localization

Androgen receptor and prostate cancer

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