Involvement of anticentromere antibody in interference with oocyte meiosis and embryo cleavage

Shirota, Kyoko; Nagata, Y.; Honjou, K.; Tsujioka, Hiroshi; Yoshizato, Toshiyuki; Miyamoto, Shingo

doi:10.1016/j.fertnstert.2011.01.013

Cited by 20 publications

(18 citation statements)

References 24 publications

(19 reference statements)

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“…These findings suggest the presence of ACA may interrupt the maturation from MI to MII of oocytes. Additionally, the cleavage rate in the AC group was markedly decreased when compared with AN group (Shirota et al, 2011).…”

Section: Discussionmentioning

confidence: 88%

Antinuclear Antibodies Predicts a Poor IVF-ET Outcome: Impaired Egg and Embryo Development and Reduced Pregnancy Rate

Ying

Zhong

Zhou

et al. 2012

Immunological Investigations

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To investigate the impact of anti-nuclear antibodies (ANAs) on the outcome of in vitro fertilization-embryo transfer (IVF-ET), 66 (96 cycles) infertile women positive for anti-nuclear antibodies (ANA+ group), and 233(285 cycles) infertile women negative for ANAs (ANA- group) were enrolled. The clinical characteristics and IVF outcome were compared between the two groups. In the ANA+ group, the proportion of MII oocytes and two-pronuclear zygotes (2PN), cleavage rate, number of available embryos and proportion of available embryos, number of high-quality embryos and proportion of high-quality embryos were significantly lower than those in the ANA- group. In addition, the pregnancy rate and implantation rate in patients positive for ANA was markedly lower than the ANA- patients (28.1% vs 46.4%, 15% vs 25.7%, respectively). Thus, our findings suggest that the presence of ANAs significantly interfere with the oocyte and embryo development, as well as reduce implantation and pregnancy rate in patients undergoing IVF treatment.

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Section: Discussionmentioning

confidence: 88%

Antinuclear Antibodies Predicts a Poor IVF-ET Outcome: Impaired Egg and Embryo Development and Reduced Pregnancy Rate

Ying

Zhong

Zhou

et al. 2012

Immunological Investigations

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show abstract

“…One in vivo test [27], in which anti-centromere antibodies were microinjected into mouse oocytes, showed the anti-centromere antibody could interfere with chromosome congression in the pro-metaphase. Shirota K et al [18] considered that anti-centromere antibodies might infiltrate oocytes and lead to centromere dysfunction during meiosis and mitosis and impair the transition from MI to MII during oocyte maturation. Ying Y et al [20] has confirmed that ANA exist in follicular fluid and embryos in ANA + patients, and serum and follicular fluid ANA negatively correlated with the number of high-quality embryos.…”

Section: Discussionmentioning

confidence: 99%

“…Shirota et al [18] found that the presence of the anti-centromere antibody might interfere with the oocyte maturation from MI to MII and impair the embryo cleavage potential. Embryo development was severely impaired or failed when co-cultured with IgG from ANA + women [19].…”

Section: Introductionmentioning

confidence: 99%

A retrospective study on IVF/ICSI outcome in patients with anti-nuclear antibodies: the effects of prednisone plus low-dose aspirin adjuvant treatment

Zhu

et al. 2013

Reprod Biol Endocrinol

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BackgroundAnti-nuclear antibodies (ANA) are suspected of having relevance to adverse reproductive events.MethodsThis study aims to investigate the potential effect of ANA on IVF/ICSI outcome and the therapeutic role of prednisone plus low-dose aspirin (P + A) adjuvant treatment in ANA + patients. The first IVF/ICSI cycles without P + A of sixty-six ANA + women were enrolled as the ANA + group, and the 233 first IVF/ICSI cycles of matched ANA- women served as the ANA- group. The ANA + group was divided into the Titre < =1:320 subgroup and the Titre > 1:320 subgroup. Twenty-one ANA + women with adverse outcomes in their first cycles (ANA + cycles without P + A) received P + A adjuvant treatment for three months before the second IVF/ICSI cycle (ANA + cycles with P + A). The clinical characteristics and the IVF/ICSI outcomes were compared, respectively, between 1) the ANA + group and the ANA- group, 2) the Titre < =1:320 subgroup and the Titre > 1:320 subgroup, and 3) the ANA + cycles without P + A and the ANA + cycles with P + A.ResultsNo significant differences were observed between each of the two-group pairs in the clinical characteristics. The ANA + group exhibited significantly lower MII oocytes rate, normal fertilisation, pregnancy and implantation rates, as well as remarkably higher abnormal fertilisation and early miscarriage rates. The Titre < =1:320 subgroup’s IVF/ICSI outcomes were as poor as those of the Titre > 1:320 subgroup. After the P + A adjuvant treatment, the number of two pro-nuclei, perfect embryos and available embryos, and the implantation rate increased significantly.ConclusionsThese observations suggest that ANA could exert a detrimental effect on IVF/ICSI outcome that might not be titre-dependent, and P + A adjuvant treatment could be useful for ANA + patients. This hypothesis should be verified in further prospective randomised studies.

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“…Several clinical studies showed that ANA was related to adverse reproductive events, including recurrent spontaneous abortion, recurrent implantation failure, and infertility (2)(3)(4)(5)(6)(7)(8)(9). Additionally, ANA may exert adverse effects on the outcome of IVF-ET (2)(3)(4)(5)10).…”

mentioning

confidence: 99%

“…However, no study had tried to explore which kind or kinds of ANA are involved in fertile events until recently: one retrospective clinical study revealed that women with positive anticentromere antibody (ACA) had a markedly lower percentage of mature oocytes and rate of embryo cleavage (10). As we know, ACA is one member of the ANA spectrum, thus one hypothesis is that ACA might be the major antibody in the ANA family that has an adverse impact on oocyte and embryo potential.…”

mentioning

confidence: 99%

Preliminary investigation of the impact of anticentromere antibody on oocyte maturation and embryo cleavage

Ying

Zhong

Zhou

et al. 2013

Fertility and Sterility

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Involvement of anticentromere antibody in interference with oocyte meiosis and embryo cleavage

Cited by 20 publications

References 24 publications

Antinuclear Antibodies Predicts a Poor IVF-ET Outcome: Impaired Egg and Embryo Development and Reduced Pregnancy Rate

Antinuclear Antibodies Predicts a Poor IVF-ET Outcome: Impaired Egg and Embryo Development and Reduced Pregnancy Rate

A retrospective study on IVF/ICSI outcome in patients with anti-nuclear antibodies: the effects of prednisone plus low-dose aspirin adjuvant treatment

Preliminary investigation of the impact of anticentromere antibody on oocyte maturation and embryo cleavage

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