Involvement of Angiogenesis in the Pathogenesis of Coronary Aneurysms

Iwańczyk, Sylwia; Lehmann, Tomasz P.; Cieślewicz, Artur; Radziemski, Artur; Malesza, Katarzyna; Wrotyński, Michał; Jagodzińśki, Paweł P.; Grygier, Marek; Lesiak, Maciej; Araszkiewicz, Aleksander

doi:10.3390/biomedicines9091269

Cited by 6 publications

(4 citation statements)

References 49 publications

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“…The results obtained in the presented study suggest that the previously reported increased signaling of VEGF-A in AAA tissues is probably reflected in higher plasma levels of VEGF-A, but not in altered expression of VEGFA in PBMCs. This conclusion could be supported by other studies, in which elevated plasma levels of VEGF-A were found in aneurysmal diseases [64][65][66][67].…”

Section: Discussionsupporting

confidence: 81%

Dysregulations of Key Regulators of Angiogenesis and Inflammation in Abdominal Aortic Aneurysm

Zalewski

Chmiel

Kołodziej

et al. 2023

IJMS

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Abdominal aortic aneurysm (AAA) is a chronic vascular disease caused by localized weakening and broadening of the abdominal aorta. AAA is a clearly underdiagnosed disease and is burdened with a high mortality rate (65–85%) from AAA rupture. Studies indicate that abnormal regulation of angiogenesis and inflammation contributes to progression and onset of this disease; however, dysregulations in the molecular pathways associated with this disease are not yet fully explained. Therefore, in our study, we aimed to identify dysregulations in the key regulators of angiogenesis and inflammation in patients with AAA in peripheral blood mononuclear cells (using qPCR) and plasma samples (using ELISA). Expression levels of ANGPT1, CXCL8, PDGFA, TGFB1, VEGFB, and VEGFC and plasma levels of TGF-alpha, TGF-beta 1, VEGF-A, and VEGF-C were found to be significantly altered in the AAA group compared to the control subjects without AAA. Associations between analyzed factors and risk factors or biochemical parameters were also explored. Any of the analyzed factors was associated with the size of the aneurysm. The presented study identified dysregulations in key angiogenesis- and inflammation-related factors potentially involved in AAA formation, giving new insight into the molecular pathways involved in the development of this disease and providing candidates for biomarkers that could serve as diagnostic or therapeutic targets.

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Section: Discussionsupporting

confidence: 81%

Dysregulations of Key Regulators of Angiogenesis and Inflammation in Abdominal Aortic Aneurysm

Zalewski

Chmiel

Kołodziej

et al. 2023

IJMS

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show abstract

“…Adverse vascular remodeling is considered to be a possible mechanism of CAAD development. [13][14][15] Therefore, assuming that the processes mentioned above involve the entire vascular bed, coronary microcirculation remodeling is thought to be a possible cause of CMD in CAAD patients. Moreover, a turbulent blood flow in aneurysms supports the development of thrombi, which may result in distal embolization and thus impair coronary microcirculation.…”

Section: Discussionmentioning

confidence: 99%

Invasive microvascular coronary circulation assessment in patients with coronary artery aneurysmal disease

Iwańczyk¹,

Smukowska-Gorynia²,

Woźniak³

et al. 2022

Polish Archives of Internal Medicine

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“…In another study, it was found that C-peptide inhibited the synthesis of collagen type IV (COL4), which is one of the building blocks of the extracellular matrix [34]. e angiogenesis process has been also implicated in the pathogenesis of CAE [35,36]. In a study by Lim et al, C-peptide was found to accelerate angiogenesis through stimulation of extracellular signalregulated kinase (ERK 1/2), Akt, and NO production using human umbilical vein endothelial cells (HUVEC) [37].…”

Section: Dicussionmentioning

confidence: 99%

The Impact of C-Peptide and Diabetes Mellitus on Coronary Ectasia and Effect of Coronary Ectasia and C-Peptide on Long-Term Outcomes: A Retrospective Cohort Study

Toprak

Kaplangöray

Palice

2022

International Journal of Clinical Practice

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Background. Coronary artery ectasia (CAE) is an entity frequently associated with atherosclerotic coronary artery disease (CAD) in clinical practice. Although it has common risk factors with atherosclerotic CAD in its development, the pathophysiology of CAE is not fully known and it is not seen in every CAD suggesting that different determinants may play a pivotal role in the development of CAD. This study aimed to reveal the impact of C-peptide and diabetes mellitus (DM) on CAE and the effect of C-peptide and coronary ectasia on long-term outcomes in patients who underwent coronary angiography. Methods. A total of 6611 patients who underwent coronary angiography were followed up retrospectively, and their major adverse cardiovascular event (MACE) status of an average of sixty months was recorded. According to their angiographic features, the patients were divided into two groups those with and without CAE. MACE development was accepted as the primary endpoint. Results. A total of 552 patients had CAE and MACE developed in 573 patients. Patients with CAE and higher C-peptide levels (Q4 + Q3) showed higher rates of MACE as compared to those without CAE and lower C-peptide levels (Q1 + Q2) (20.8% vs 7.6%; 70.1% vs 29.1%; p < 0.001 , for both of them). In multivariate regression analysis, high C-peptide levels were determined as an independent risk factor for CAE (OR 2.417; 95% CI 2.212–2.641; p < 0.001 ). The Kaplan–Meier cumulative survival curves showed that the risks for MACE increased as the C-peptide levels increased. The Cox regression analysis for 5-years MACE related to the plasma C-peptide levels and presence of CAE, C-peptide, and CAE were found to be independent predictors of MACE (HR = 1.255, 95% CI: 1.164–1.336, p < 0.001 and HR = 1.012, 95% CI: 1.002–1.023, p = 0.026 , respectively). Conclusion. Our study revealed that a high C-peptide level is an independent risk factor for CAE and that CAE and C-peptide are independent predictors for the development of MACE.

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Involvement of Angiogenesis in the Pathogenesis of Coronary Aneurysms

Cited by 6 publications

References 49 publications

Dysregulations of Key Regulators of Angiogenesis and Inflammation in Abdominal Aortic Aneurysm

Dysregulations of Key Regulators of Angiogenesis and Inflammation in Abdominal Aortic Aneurysm

Invasive microvascular coronary circulation assessment in patients with coronary artery aneurysmal disease

The Impact of C-Peptide and Diabetes Mellitus on Coronary Ectasia and Effect of Coronary Ectasia and C-Peptide on Long-Term Outcomes: A Retrospective Cohort Study

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