Involvement of Amlodipine, Diazoxide, and Glibenclamide in Development of Morphine Tolerance in Mice

Khalilzadeh, Omid; Anvari, Mehdi; Khalilzadeh, Azita; Sahebgharani, Mousa; Zarrindast, Mohammad Reza

doi:10.1080/00207450601123530

Cited by 12 publications

(11 citation statements)

References 26 publications

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“…These substances and their dosages, were selected in accordance with data from scientific literature and experiments that had previously been done at our laboratory. The antagonists that were used in this study did not have any effect per se at the doses that were used Duman et al, 2004;De Campos et al, 1996;Luiz et al, 2007;Ray et al, 2004;Khalilzadeh et al, 2008).…”

Section: Formalin Testmentioning

confidence: 97%

Antinociceptive effect of topiramate in models of acute pain and diabetic neuropathy in rodents

et al. 2009

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Section: Formalin Testmentioning

confidence: 97%

Antinociceptive effect of topiramate in models of acute pain and diabetic neuropathy in rodents

et al. 2009

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“…After an adaptation period of 15 min, the right hind footpaw was injected with 50 ml of 2.5% formalin in the intraplantar region. Nociception was evaluated by quantifying paw licking time and paw elevation time during the first 10 min (acute phase) and at 20-40 min (delayed phase) (Luiz et al, 2007;Khalilzadeh et al, 2008).…”

Section: Behavioural Assessmentmentioning

confidence: 99%

Standardized Aqueous Tribulus terristris (Nerunjil) Extract Attenuates Hyperalgesia in Experimentally Induced Diabetic Neuropathic Pain Model: Role of Oxidative Stress and Inflammatory Mediators

Ranjithkumar¹,

Balaji²,

Bhaskar³

et al. 2012

Phytotherapy Research

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The present study aimed to evaluate standardized aqueous Tribulus terristris (nerunjil) extract on the pain threshold response in streptozotocin (STZ)-induced diabetic neuropathic pain model in rats. After a single injection of STZ (40 mg/kg; i.p.), Wistar male rats were tested by the thermal and chemical-induced pain models. Diabetic rats exhibited significant hyperalgesia, and these rats were left untreated for the first four weeks. Thereafter, treatment was initiated and continued up to week-8. All the rats except the vehicle-treated group received insulin 5 IU/kg/day to maintain plasma glucose levels. Treatment with nerunjil (100 and 300 mg/kg; p.o.) for 4 weeks significantly attenuated the nociception in behavioural models. Nerunjil also inhibited the tumour necrosis factor-α and interleukin-1 beta levels. The effect of nerunjil (300 mg/kg) is comparable to the standard drug Pregabalin (100 mg/kg). Nerunjil increased the superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, and decreased the lipid peroxide levels in dose-dependent manner. Insulin alone-treated rats failed to attenuate hyperalgesic response. In comparison to insulin alone-treated rats, nerunjil exhibited significant increase in the pain threshold response. It could be concluded that in controlled diabetic states, nerunjil attenuated the neuropathic pain through modulation of oxidative stress and inflammatory cytokine release.

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“…Openers of ATP-sensitive K + -channels (K þ ATP ), such as minoxidil, pinacidil or cromakalim [14,15] enhance morphine-induced antinociception when administered centrally i.e. either intrathecally or intracerebroventricularly [8,[16][17][18][19][20]. The modulatory effect of K þ ATP acting drugs seems rather selective, as blockers of other types of K + -channels (including Ca 2+ -and voltage dependent K + -channels such as 4-aminopyridine or tetraethylammonium) [21,22] have no effect on morphine or clonidine-induced Keywords antinociception, formalin test, morphine, potassium channel openers, tail-flick test…”

Section: Introductionmentioning

confidence: 99%

Interaction of morphine and potassium channel openers on experimental models of pain in mice

Khanna

Malhotra

Mehta

et al. 2010

Fundamental &Amp; Clinical Pharmacology

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Combination of opioid and potassium channel openers holds immense potential for the treatment for most acute and chronic pain. Therefore, the study was performed to assess the interaction between morphine and K(+) -channel openers. Swiss albino mice of either sex weighing between 25 and 30 g were used for the study. The study assesses the interaction between morphine and K(+) -channel openers (cromakalim, diazoxide and minoxidil), when administered intraperitoneally, using formalin and tail-flick tests in mice. Both morphine and K(+) -channel openers produced significant antinociception at higher doses in both the behavioral tests. Lower doses of morphine and K(+) -channel openers had no significant effect on tail-flick latency, while the same drugs had significant antinociceptive effect on formalin test. The combination of lower doses of morphine and K(+) -openers was observed to have significant antinociceptive effect in both the behavioral tests. Administration of naloxone prior to morphine or K(+) -channel openers antagonized the analgesic effect of morphine but not of K(+) -channel openers, whereas prior administration of glibenclamide antagonized the effect of both morphine and K(+) -channel openers. The study, therefore, suggests that the common site of action of morphine and K(+) -channel openers is at the levels of K(+) -channels rather than at the level of receptors. However, such interaction depends on the differential sensitivity to different pain stimulus.

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Involvement of Amlodipine, Diazoxide, and Glibenclamide in Development of Morphine Tolerance in Mice

Cited by 12 publications

References 26 publications

Antinociceptive effect of topiramate in models of acute pain and diabetic neuropathy in rodents

Antinociceptive effect of topiramate in models of acute pain and diabetic neuropathy in rodents

Standardized Aqueous Tribulus terristris (Nerunjil) Extract Attenuates Hyperalgesia in Experimentally Induced Diabetic Neuropathic Pain Model: Role of Oxidative Stress and Inflammatory Mediators

Interaction of morphine and potassium channel openers on experimental models of pain in mice

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