Involvement of Adenosine in the Antiinflammatory Action of Ketamine

Mazar, Julia; Rogachev, Boris; Shaked, Gad; Ziv, Nadav; Czeiger, David; Chaimovitz, Cidio; Zlotnik, Moshe; Mukmenev, Igor; Byk, Gérardo; Douvdevani, Amos

doi:10.1097/00000542-200506000-00017

Cited by 74 publications

(47 citation statements)

References 25 publications

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“…In addition, literature data show that creatine produced anti-inflammatory effects in endothelial cells that were suppressed by ZM241385 [63]. Similar to our results, the anti-inflammatory effect of ketamine was also blocked by ZM241385 treatment [64]. In addition, the pretreatment of mice with the selective adenosine A 2A receptor agonist DPMA was able to cause a synergistic effect with subeffective doses of creatine or ketamine in the TST, reinforcing the importance of adenosine A 2A receptor activation for the antidepressant-like effect of these compounds.…”

Section: Discussionsupporting

confidence: 92%

Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A1 and A2A receptor activation

Cunha

Pazini

Rosa

et al. 2015

Purinergic Signalling

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The benefits of creatine supplementation have been reported in a broad range of central nervous systems diseases, including depression. A previous study from our group demonstrated that creatine produces an antidepressant-like effect in the tail suspension test (TST), a predictive model of antidepressant activity. Since depression is associated with a dysfunction of the adenosinergic system, we investigated the involvement of adenosine A 1 and A 2A receptors in the antidepressant-like effect of creatine in the TST. The anti-immobility effect of creatine (1 mg/kg, po) or ketamine (a fast-acting antidepressant, 1 mg/kg, ip) in the TST was prevented by pretreatment of mice with caffeine (3 mg/kg, ip, nonselective adenosine receptor antagonist), 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) (2 mg/kg, ip, selective adenosine A 1 receptor antagonist), and 4-(2-[7-amino-2-{2-furyl}{1,2,4}triazolo-{2,3-a}{1,3,5}triazin-5-ylamino]ethyl)-phenol (ZM241385) (1 mg/kg, ip, selective adenosine A 2A receptor antagonist). In addition, the combined administration of subeffective doses of creatine and adenosine (0.1 mg/kg, ip, nonselective adenosine receptor agonist) or inosine (0.1 mg/kg, ip, nucleoside formed by the breakdown of adenosine) reduced immobility time in the TST. Moreover, the administration of subeffective doses of creatine or ketamine combined with N-6-cyclohexyladenosine (CHA) (0.05 mg/kg, ip, selective adenosine A 1 receptor agonist), N-6-[2-(3,5-dimethoxyphenyl)-2-(methylphenyl)ethyl]adenosine (DPMA) (0.1 mg/kg, ip, selective adenosine A 2A receptor agonist), or dipyridamole (0.1 μg/mouse, icv, adenosine transporter inhibitor) produced a synergistic antidepressant-like effect in the TST. These results indicate that creatine, similarly to ketamine, exhibits antidepressant-like effect in the TST probably mediated by the activation of both adenosine A 1 and A 2A receptors, further reinforcing the potential of targeting the purinergic system to the management of mood disorders.

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Section: Discussionsupporting

confidence: 92%

Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A1 and A2A receptor activation

Cunha

Pazini

Rosa

et al. 2015

Purinergic Signalling

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“…11 Since antiinflammatory effect of ketamine is dose-related, 26 higher dose of ketamine could have attenuated inflammatory reactions in OPCAB. It should be considered that a larger dose of ketamine can elicit adverse haemodynamic modifications towards an increase in myocardial oxygen consumption, 27 since ketamine produces a dose-related increase in cardiovascular stimulation.…”

Section: Discussionmentioning

confidence: 99%

Effect of low-dose ketamine on inflammatory response in off-pump coronary artery bypass graft surgery

Cho¹,

Shim

Choi³

et al. 2009

British Journal of Anaesthesia

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“…Statistical analysis revealed no significant difference between the groups. Ketamine due to its extrapyramidal activation, increased electrical activity at the basal ganglia, brain stem and limbic system produced muscle tremors, limb stretching and tonic clonic convulsion (Mazar et al, 2005 andVisser andSchug, 2006). The muscle relaxation observed during xylazine -acepromazine premedication could be attributed to decrease intraneuronal transmission of impulses from the muscles to the central nervous system (Haskins et al, 1975) and decreased motor activity (Gleed, 1987).…”

Section: Resultsmentioning

confidence: 99%

Analgesic and adjunct actions of nalbuphine hydrochloride in xylazine or xylazine and acepromazine premedicated horses

Kulkarni

William

George

et al. 2015

IJAR

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The study was conducted in eighteen clinical cases of horses for diagnostic and surgical procedures requiring general anaesthesia were randomly divided into three groups, group I, group II and group III, each consisting of six cases. All the horses were premedicated with glycopyrrolate at the dose rate of 0.02 mg/kg body weight, intravenously. Horses in Group I and Group II were administered xylazine hydrochloride at the dose rate of 1.10 mg/kg body weight intravenously, whereas in Group III at the dose rate of 0.50 mg/kg body weight intravenously. In Group III, acepromazine was injected after xylazine administration, at the dose rate of 0.02mg/kg body weight, intravenously. Before induction of anaesthesia, nalbuphine hydrochloride was administered for Group II and Group III at the dose rate of 0.75 mg/kg body weight intravenously. Ketamine hydrochloride was administered intravenously to induce anaesthesia at the dose rate of 2.20 mg/kg body weight and maintained with 0.50 mg/kg body weight in required cases to maintain for duration of 15 ± 1.04 minutes. The mean time for induction in group I, group II and group III were 1.78 ± 0.27, 1.73 ± 0.10 and 1.85 ± 0.28 minutes respectively. The mean total number of additional doses of ketamine for standard duration of 15 ± 1.04 minutes surgery required in group I, group II and group III were 5.00 ± 0.36, 1.66 ± 0.33 and 2.00 ± 0.36 respectively. The quality of induction was 100 per cent smooth in group III, 83.33 per cent smooth and 16.67 per cent rough in group II and 66.66 per cent smooth and 33.34 per cent rough in group I. The quality of analgesia in group I, group II and group III were 2.83 ± 0.47, 1.83 ± 0.30 and 1.33 ± 0.21 respectively. The quality of muscle relaxation in group I, group II and group III were 3.16 ± 0.30, 1.50 ± 0.22 and 1.33 ± 0.21 respectively. The mean time for recovery in group I, group II and group III were 23.00 ± 1.52, 33.00 ± 0.93 and 41.98 ± 1.32 minutes respectively. The mean number of attempts for unassisted standing in group I, group II and group III were 6.66 ± 0.71, 5.00 ± 0.57 and 5.00 ± 0.36 respectively. The quality of recovery was 83.33 per cent smooth and 16.67 per cent rough in group III, 66.66 per cent smooth and 33.34 per cent rough in group II and 50.00 per cent smooth and 50.00 per cent rough in group I. None of the animals in any groups showed any intra and post operative complication.

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Involvement of Adenosine in the Antiinflammatory Action of Ketamine

Abstract: The current data suggest that the sepsis-protective antiinflammatory effects of ketamine are mediated by the release of adenosine acting through the A2A receptor.

Cited by 74 publications

References 25 publications

Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A1 and A2A receptor activation

Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A1 and A2A receptor activation

Effect of low-dose ketamine on inflammatory response in off-pump coronary artery bypass graft surgery

Analgesic and adjunct actions of nalbuphine hydrochloride in xylazine or xylazine and acepromazine premedicated horses

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