Involvement of 5-hydroxytryptamine type 3 receptors in sevoflurane-induced hypnotic and analgesic effects in mice

Abstract

Abstract:In the present study, we investigated the role of 5-hydroxytryptamine type 3 (5-HT 3 ) receptors in hypnosis and analgesia induced by emulsified sevoflurane. A mouse model of hypnosis and analgesia was established by an intraperitoneal or subcutaneous injection of emulsified sevoflurane. We intracerebroventricularly (icv) or intrathecally (it) administered YM-31636, a 5-HT 3 receptor agonist, to mice and observed sleep time during hypnosis. In addition, the tail withdrawal latency was measured using the tail withdrawal test, and the writhing time was determined using the acetic acid writhing test. In the hypnosis test, YM-31636 (5, 10 and 15 µg, icv) treatment significantly decreased emulsified sevoflurane-induced mouse sleep time (p < 0.05 or p < 0.01). YM-31636 (2.5, 5 and 10 µg, it) treatment significantly and dose-dependently decreased the tail withdrawal latency (p < 0.05 or p < 0.01) and increased the writhing time (p < 0.01) of mice treated with emulsified sevoflurane. These results suggest that 5-HT 3 receptors may modulate the hypnotic and analgesic effects induced by emulsified sevoflurane.

Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction

“…Among the many recognized 5-HT receptors, 5-HT 1A and 5- HT 3 receptors are targets for sevoflurane, the binding of which enhances their activation ( Suzuki et al, 2002 ; Hang et al, 2010 ; Qiu et al, 2018 ). Surgical patients, especially children, receiving sevoflurane frequently experience restlessness in the postoperative period ( Kanaya et al, 2014 ).…”

The GABAergic system as a therapeutic target for Alzheimer's disease

“…Further research is needed, keeping in mind the fact that sevoflurane also acts at a number of other molecular targets, including NMDA receptors (Brosnan and Thiesen ), serotonin (5‐HT 3 ) receptors (Hang et al . ), nicotinic acetylcholine receptors (Scheller et al . ), and glycine receptors (Kira et al .…”

“…Since it is theorized that cognitive impairment in AD might be related to the dysregulation of kinase activity and tau hyperphosphorylation, this could implicate GABA A Rs as novel targets in the prevention of tau aggregation and hyperphosphorylation. Further research is needed, keeping in mind the fact that sevoflurane also acts at a number of other molecular targets, including NMDA receptors (Brosnan and Thiesen 2012), serotonin (5-HT 3 ) receptors (Hang et al 2010), nicotinic acetylcholine receptors (Scheller et al 1997), and glycine receptors (Kira et al 1998), with diverse pharmacological mechanisms of action. Thus, it is difficult to determine the extent to which GABA A R-mediated processes contribute to sevoflurane-induced tau hyperphosphorylation, spatial memory deterioration, and LTP impairment.…”

Volatile Anesthetics Regulate Anti-Cancer Relevant Signaling

“…In the electrophysiological study of neurons and recombinant receptors, sevoflurane is a positive allosteric modulator of the GABA A receptors (16)(17)(18). However, it can also act as a NMDA receptor antagonist (19), enhancing glycine receptor electro-currents (20) and inhibiting nAChR (21) and 5-HT3 receptor currents (22,23). Sevoflurane is particularly non-irritating to the respiratory tract, so it is particularly suitable for asthma patients' anesthesia.…”