Involvement of 5-HT7 receptors in the pathogenesis of temporal lobe epilepsy

Yang, Zhiyong; Liu, Xijin; Yin, Yaping; Sun, Shan; Deng, Xuejun

doi:10.1016/j.ejphar.2012.04.011

Cited by 43 publications

(28 citation statements)

References 36 publications

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“…reduces the occurrence and intrinsic frequency of ripples in the CA1 area of freely-behaving rats (Ponomarenko et al, 2003). Moreover, a link between serotonin and TLE was proposed based on the finding that the serotonin 5-HT 7 antagonist SB269970 decreases the number of spike-wave discharges in pilocarpine-treated rats (Yang et al, 2012). In the same study, increased expression of 5-HT 7 receptors was observed in the temporal neocortex of patients with intractable epilepsy.…”

Section: Discussionmentioning

confidence: 93%

“…The serotonergic system has been implicated in the pathophysiology and treatment of epilepsy (Statnick et al, 1996;Bagdy et al, 2007;Yang et al, 2012). Drugs that increase extracellular serotonin concentrations, such as selective serotonin reuptake inhibitors (SSRIs), have anticonvulsant properties (Yan et al, 1994;Choi et al, 2010;Vermoese et al, 2012;Yang et al, 2012;Igelström, 2012), while those that decrease serotonin levels can induce seizures (Bagdy et al, 2007).…”

Section: Introductionmentioning

confidence: 97%

“…Drugs that increase extracellular serotonin concentrations, such as selective serotonin reuptake inhibitors (SSRIs), have anticonvulsant properties (Yan et al, 1994;Choi et al, 2010;Vermoese et al, 2012;Yang et al, 2012;Igelström, 2012), while those that decrease serotonin levels can induce seizures (Bagdy et al, 2007). Interestingly, in both the KA model of epilepsy and in patients with TLE very high occurrence of FRs have been reported in slow wave sleep, a period during which serotonin levels decrease (Park et al, 1999;Staba et al, 2004).…”

Section: Introductionmentioning

confidence: 98%

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Serotonin modulates fast ripple activity in rats with spontaneous recurrent seizures

2014

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Serotonin modulates fast ripple activity in rats with spontaneous recurrent seizures

2014

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“…However, seven died. After 33 ± 6.5 days[34], 19 status epilepticus rats that did not have spontaneous recurrent seizures served as the spontaneous recurrent seizures-free group. The 24 remaining rats were exposed to the spontaneous recurrent seizures phase and behavioral observations by video surveillance showed spontaneous recurrent seizures in this group.…”

Section: Resultsmentioning

confidence: 99%

Increased expression of Notch1 in temporal lobe epilepsy: animal models and clinical evidence

et al. 2014

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Temporal lobe epilepsy is associated with astrogliosis. Notch1 signaling can induce astrogliosis in glioma. However, it remains unknown whether Notch1 signaling is involved in the pathogenesis of epilepsy. This study investigated the presence of Notch1, hairy and enhancer of split-1, and glial fibrillary acidic protein in the temporal neocortex and hippocampus of lithium-pilocarpine-treated rats. The presence of Notch1 and hairy and enhancer of split-1 was also explored in brain tissues of patients with intractable temporal lobe epilepsy. Quantitative electroencephalogram analysis and behavioral observations were used as auxiliary measures. Results revealed that the presence of Notch1, hairy and enhancer of split-1, and glial fibrillary acidic protein were enhanced in status epilepticus and vehicle-treated spontaneous recurrent seizures rats, but remain unchanged in the following groups: control, absence of either status epilepticus or spontaneous recurrent seizures, and zileuton-treated spontaneous recurrent seizures. Compared with patient control cases, the presences of Notch1 and hairy and enhancer of split-1 were upregulated in the temporal neocortex of patients with intractable temporal lobe epilepsy. Therefore, these results suggest that Notch1 signaling may play an important role in the onset of temporal lobe epilepsy via astrogliosis. Furthermore, zileuton may be a potential therapeutic strategy for temporal lobe epilepsy by blocking Notch1 signaling.

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“…In line with this, a pharmacological study using different mixed antagonists suggested that blockade of 5-HT 7 receptors may protect against audiogenic seizures in DBA/2J mice (Bourson et al, 1997). Pharmacological blockade using selective 5-HT 7 receptor antagonists decreased cortical epileptic activity in a rat genetic model of absence epilepsy (Graf et al, 2004) and in a pilocarpine-induced rat model of temporal lobe epilepsy (Yang et al, 2012). …”

Section: Involvement Of 5-ht7 Receptors In Pathologymentioning

confidence: 99%

5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders

Ciranna

Catania

2014

Front. Cell. Neurosci.

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Serotonin type 7 receptors (5-HT7) are expressed in several brain areas, regulate brain development, synaptic transmission and plasticity, and therefore are involved in various brain functions such as learning and memory. A number of studies suggest that 5-HT7 receptors could be potential pharmacotherapeutic target for cognitive disorders. Several abnormalities of serotonergic system have been described in patients with autism spectrum disorder (ASD), including abnormal activity of 5-HT transporter, altered blood and brain 5-HT levels, reduced 5-HT synthesis and altered expression of 5-HT receptors in the brain. A specific role for 5-HT7 receptors in ASD has not yet been demonstrated but some evidence implicates their possible involvement. We have recently shown that 5-HT7 receptor activation rescues hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome, a monogenic cause of autism. Several other studies have shown that 5-HT7 receptors modulate behavioral flexibility, exploratory behavior, mood disorders and epilepsy, which include core and co-morbid symptoms of ASD. These findings further suggest an involvement of 5-HT7 receptors in ASD. Here, we review the physiological roles of 5-HT7 receptors and their implications in Fragile X Syndrome and other ASD.

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Involvement of 5-HT7 receptors in the pathogenesis of temporal lobe epilepsy

Cited by 43 publications

References 36 publications

Serotonin modulates fast ripple activity in rats with spontaneous recurrent seizures

Serotonin modulates fast ripple activity in rats with spontaneous recurrent seizures

Increased expression of Notch1 in temporal lobe epilepsy: animal models and clinical evidence

5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders

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