Genetic polymorphisms may affect human male fertility. Even though TP53 plays a role in spermatogenesis we know little about the association of the functional polymorphism at codon 72 of TP53 with respect to susceptibility to male infertility. We conducted a case-control study to investigate this association in a Chinese population and performed a meta-analysis in different populations to clarify this association. The single nucleotide polymorphism (SNP) of TP53 codon 72 (rs1042522 G4C) was genotyped by PCR-RFLP in 83 Chinese male infertility patients and 401 healthy controls. Meta-analysis was performed using the data from four currently available studies. The data from our study were overlayed using the v.9.0 STATA software package. We observed no association between the TP53 codon 72 polymorphism and male infertility (p ¼ 0.84, OR ¼ 1.04, 95% CI, 0.74-1.45). Meta-analysis confirmed the casecontrol result that there was no significant association between the codon 72 polymorphism of Abbreviations: Arg: arginine allele; CI: confidence interval; HWE Hardy-Weinberg equilibrium; OR: odds ratio; PCR-RFLP: polymerase chain reaction-estriction fragment length polymorphism; Pro: proline allele; SNP: single nucleotide polymorphism; TP53: tumor protein 53.