Invitro toxicity test and searching the possibility of cancer cell line extermination by magnetic heating with using Fe<sub>3</sub>O<sub>4</sub>magnetic fluid

Linh, Pham Hoai; Thuan, Nguyen Chi; Tuấn, Nguyễn Anh; Thach, Pham Van; Yen, Tran Cong; Quy, Nguyen Thi; Nhung, Hoang Thi My; Xuyen, Phi Thi; Phuc, N.X.; Hong, Le Van

doi:10.1088/1742-6596/187/1/012008

Cited by 7 publications

(5 citation statements)

References 18 publications

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“…Either through direct injection − or the use of a targeting moiety on an i.v.-administered particle, , these IONPs have the potential to provide heat directly to the area of treatment while also providing clinicians with an accurate picture of particle localization and concentration. A number of groups have shown preclinical efficacy for a variety of cancers, ,− and this approach has been clinically approved in the European Union for treatment of glioblastoma multiforme . Further, this localized IONP-based hyperthermia has been shown to increase the efficacy of both radiation , and a variety of chemotherapeutics. ,, Despite preliminary successes, the great potential of IONPs has been limited by several factors including the need for high field strengths for therapeutically relevant heating and the presence of magnetically “dead” sites within some magnetic particles .…”

Section: Introductionmentioning

confidence: 99%

Predictable Heating and Positive MRI Contrast from a Mesoporous Silica-Coated Iron Oxide Nanoparticle

et al. 2016

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Iron oxide nanoparticles have great potential as diagnostic and therapeutic agents in cancer and other diseases; however, biological aggregation severely limits their function in vivo. Aggregates can cause poor biodistribution, reduced heating capability, and can confound their visualization and quantification by magnetic resonance imaging (MRI). Herein, we demonstrate that the incorporation of a functionalized mesoporous silica shell can prevent aggregation and enable the practical use of high-heating, high-contrast iron oxide nanoparticles in vitro and in vivo. Unmodified and mesoporous silica-coated iron oxide nanoparticles were characterized in biologically relevant environments including phosphate buffered saline, simulated body fluid, whole mouse blood, lymph node carcinoma of prostate (LNCaP) cells, and after direct injection into LNCaP prostate cancer tumors in nude mice. Once coated, iron oxide nanoparticles maintained colloidal stability along with high heating and relaxivity behaviors (SARFe = 204 W/g Fe at 190 kHz and 20 kA/m and r1 = 6.9 mM(-1) s(-1) at 1.4 T). Colloidal stability and minimal nonspecific cell uptake allowed for effective heating in salt and agarose suspensions and strong signal enhancement in MR imaging in vivo. These results show that (1) aggregation can lower the heating and imaging performance of magnetic nanoparticles and (2) a coating of functionalized mesoporous silica can mitigate this issue, potentially improving clinical planning and practical use.

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Section: Introductionmentioning

confidence: 99%

Predictable Heating and Positive MRI Contrast from a Mesoporous Silica-Coated Iron Oxide Nanoparticle

et al. 2016

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“…For ρ N = 5 · 10 21 (m −3 ) and an average tumor cell radius of r cell = 7 μm [52], the number of MNPs inside a single cell can be calculated to equal 8 · 10 6 that fits the concentrations found by Linh et al [66] and Balivada et al [67]. From ρ N , we calculated the distances between two neighboring particles that is approximately 58 nm.…”

Section: Discussionmentioning

confidence: 83%

“…However, for larger magnetic concentration occupying a single cell such as 1 ng of Fe 3 O 4 per human cell, that is, equivalent to 5·10 7 MNPs per cell (for a particle radius 10 nm and cell radius 5 μm), Linh et al [66] and Balivada et al [67] showed that a local temperature elevation of several degrees can be reached making MH treatments effective. In addition, these quantities were also proposed by Vera and Bayazitoglu [59], Chan et al [61], Huang [64], and Melancon et al [65] who proved their efficiency in inducing MH.…”

Section: Discussionmentioning

confidence: 99%

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An Analytic Analysis of the Diffusive-Heat-Flow Equation for Different Magnetic Field Profiles for a Single Magnetic Nanoparticle

Dana

Gannot

2012

Journal of Atomic, Molecular, and Optical Physics

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This study analytically analyzes the changes in the temperature profile of a homogenous and isotropic medium having the same thermal parameters as a muscular tissue, due to the heat released by a single magnetic nanoparticle (MNP) to its surroundings when subject to different magnetic field profiles. Exploring the temperature behavior of a heated MNP can be very useful predicting the temperature increment of it immediate surroundings. Therefore, selecting the most effective magnetic field profile (MFP) in order to reach the necessary temperature for cancer therapy is crucial in hyperthermia treatments. In order to find the temperature profile caused by the heated MNP immobilized inside a homogenous medium, the 3D diffusive-heat-flow equation (DHFE) was solved for three different types of boundary conditions (BCs). The change in the BC is caused by the different MF profiles (MFP), which are analyzed in this article. The analytic expressions are suitable for describing the transient temperature response of the medium for each case. The analysis showed that the maximum temperature increment surrounding the MNP can be achieved by radiating periodic magnetic pulses (PMPs) on it, making this MFP more effective than the conventional cosine profile.

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“…This difference may be due to the presence of cancer cells in the heated solutions. Previous studies also indicate that the temperatures of cell-containing solutions are always lower than that of solutions consisting of magnetic NPs only [ 1 , 46 , 47 ]. Even so, a temperature of 41.5 °C can still potentially kill cancer cells, with 20% of sarcoma cells dying ( Figure 7 B,C).…”

Section: Discussionmentioning

confidence: 99%

High Biocompatibility, MRI Enhancement, and Dual Chemo- and Thermal-Therapy of Curcumin-Encapsulated Alginate/Fe3O4 Nanoparticles

Nguyen

et al. 2023

Pharmaceutics

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(1) Background: Magnetite (Fe3O4) nanoparticles have great potential for biomedical applications, including hyperthermia and magnetic resonance imaging. In this study, we aimed to identify the biological activity of nanoconjugates composed of superparamagnetic Fe3O4 nanoparticles coated with alginate and curcumin (Fe3O4/Cur@ALG) in cancer cells. (2) Methods: The nanoparticles were evaluated for the biocompatibility and toxicity on mice. The MRI enhancement and hyperthermia capacities of Fe3O4/Cur@ALG were determined in both in vitro and in vivo sarcoma models. (3) Results: The results show that the magnetite nanoparticles exhibit high biocompatibility and low toxicity in mice at Fe3O4 concentrations up to 120 mg/kg when administered via intravenous injection. The Fe3O4/Cur@ALG nanoparticles enhance the magnetic resonance imaging contrast in cell cultures and tumor-bearing Swiss mice. The autofluorescence of curcumin also allowed us to observe the penetration of the nanoparticles into sarcoma 180 cells. In particular, the nanoconjugates synergistically inhibit the growth of sarcoma 180 tumors via magnetic heating and the anticancer effects of curcumin, both in vitro and in vivo. (4) Conclusions: Our study reveals that Fe3O4/Cur@ALG has a high potential for medicinal applications and should be further developed for cancer diagnosis and treatment.

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Invitro toxicity test and searching the possibility of cancer cell line extermination by magnetic heating with using Fe₃O₄magnetic fluid

Cited by 7 publications

References 18 publications

Predictable Heating and Positive MRI Contrast from a Mesoporous Silica-Coated Iron Oxide Nanoparticle

Predictable Heating and Positive MRI Contrast from a Mesoporous Silica-Coated Iron Oxide Nanoparticle

An Analytic Analysis of the Diffusive-Heat-Flow Equation for Different Magnetic Field Profiles for a Single Magnetic Nanoparticle

High Biocompatibility, MRI Enhancement, and Dual Chemo- and Thermal-Therapy of Curcumin-Encapsulated Alginate/Fe3O4 Nanoparticles

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Invitro toxicity test and searching the possibility of cancer cell line extermination by magnetic heating with using Fe3O4magnetic fluid

Cited by 7 publications

References 18 publications

Predictable Heating and Positive MRI Contrast from a Mesoporous Silica-Coated Iron Oxide Nanoparticle

Predictable Heating and Positive MRI Contrast from a Mesoporous Silica-Coated Iron Oxide Nanoparticle

An Analytic Analysis of the Diffusive-Heat-Flow Equation for Different Magnetic Field Profiles for a Single Magnetic Nanoparticle

High Biocompatibility, MRI Enhancement, and Dual Chemo- and Thermal-Therapy of Curcumin-Encapsulated Alginate/Fe3O4 Nanoparticles

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Invitro toxicity test and searching the possibility of cancer cell line extermination by magnetic heating with using Fe₃O₄magnetic fluid