Abstract:Tertiary alcohols are widely present in natural products, pharmaceuticals, and agrochemicals. Radical addition reaction to ketones is a simple and waste-free synthetic method for preparation of tertiary alcohols with high functional group tolerance. Therefore, direct radical addition reactions to ketones can be applied to a wider range of substrates. However, radical addition to carbonyl groups is a thermodynamically unfavored process, especially in the case of intermolecular radical addition to ketones, where… Show more
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