(INVITED)Surface enhanced infrared absorption spectroscopy using plasmonic nanostructures: Alternative ultrasensitive on-chip biosensor technique

Label-free detection of MiRNA biomarkers using broadband multi-resonant infrared metasurfaces for early breast cancer diagnosis

“…SEIRA is a technique based on the resonant effect of the metasurface nanostructures at the substrate surface, where the molecules interact with the incident light to improve the sensitivity of infrared spectroscopy measurements. 11,12 The resonance wavelength(s) can be tuned by the material, shape, and size of the nanostructures. Many nanostructures have been proposed, including zig-zag nanotips, nanorods, nanodiscs, nanoislands, etc.…”

Enhanced label-free detection of proteins on Au nanoparticle micropatterns for surface-enhanced infrared absorption spectroscopy

“…12 Various plasmonic nanostructures have been explored, including metallic nanoparticles, nanoholes, and nanoantennas to enhance the IR signal. 13,14 These structures are designed to exhibit strong localized surface plasmon resonance (LSPRS) that enhances the electromagnetic field in the vicinity of the surface, leading to increased sensitivity. 15 Advances in substrate fabrication techniques have enabled precise control over nanostructure morphology and distribution, leading to improved reproducibility and sensitivity in SEIRAS.…”

“…12 Various plasmonic nanostructures have been explored, including metallic nanoparticles, nanoholes, and nanoantennas to enhance the IR signal. 13,14 These structures are designed to exhibit strong localized surface plasmon resonance (LSPRS) that enhances the electromagnetic field in the vicinity of the surface, leading to increased sensitivity. 15…”