Invited letter concerning: Neutrophil activation during cardiopulmonary bypass

Wj, Dreyer; Cw, Smith; Ml, Entman

doi:10.1016/s0022-5223(19)36565-1

Cited by 18 publications

(1 citation statement)

References 8 publications

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“…There are also reports that neutrophil responses to stimulation by complement or IL-8 may be reduced after CPB. 27,28 These results suggest that being able to pharmacologically downregulate the response by neutrophils, for example by use of LTB 4 receptor antagonists, may be of benefit in patients undergoing CPB.…”

mentioning

confidence: 98%

Differential expression of neutrophil adhesion molecules during coronary artery surgery with cardiopulmonary bypass

Ilton

Langton

Taylor

et al. 1999

The Journal of Thoracic and Cardiovascular Surgery

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mentioning

confidence: 98%

Differential expression of neutrophil adhesion molecules during coronary artery surgery with cardiopulmonary bypass

Ilton

Langton

Taylor

et al. 1999

The Journal of Thoracic and Cardiovascular Surgery

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Leukocyte?biomaterial interactions in the presence ofStaphylococcus epidermidis: Flow cytometric evaluation of leukocyte activation (Student Research Award in the Hospital Intern, Resident, or Clinical Fellow Category, 23rd Annual Meeting of the Society for Biomaterials, New Orleans, LA, April 30-May 4, 1997)

Sapatnekar

Kao

Anderson

1997

J. Biomed. Mater. Res.

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The adhesion of bacteria on a biomaterial surface significant complement activation. PMN adhesion on the biois believed to be the first step in the development of biomate-material surface was sensitive to shear stress and minimal rial-related infection. The goal of this study was to investigate at shear stress Ͼ10 dynes/cm 2 . Low concentrations of bactethe mechanisms that permit adherent bacteria to persist on ria could induce a significant increase in the expression of the surface of an implanted cardiovascular biomaterial. We PMN adhesion molecules CD11b and CD11c. We conclude hypothesized that circulating leukocytes are unable to adhere that the presence of bacteria induces PMN activation but to the biomaterial surface under physiologic shear stress con-does not increase PMN adhesion on biomaterial surfaces ditions, and this prevents them from interacting with adher-under physiologic shear stress conditions. This could be a ent bacteria. To address this hypothesis, we investigated the major mechanism that protects adherent bacteria from PMN adhesion profiles of Staphylococcus epidermidis and polymor-antibacterial activity. © 1997 John Wiley & Sons, Inc. J Biomed phonuclear leukocytes (PMN), incubated under controlled Mater Res, 35, 409-420, 1997. shear stress conditions with the test biomaterial. We found that bacteria could adhere on the biomaterial surface, even

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Role of Complement in Myocardial Ischemia and Infarction

Walsh¹,

Hart²,

Bourcier³

et al.

The Complement System

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Invited letter concerning: Neutrophil activation during cardiopulmonary bypass

Cited by 18 publications

References 8 publications

Differential expression of neutrophil adhesion molecules during coronary artery surgery with cardiopulmonary bypass

Differential expression of neutrophil adhesion molecules during coronary artery surgery with cardiopulmonary bypass

Role of Complement in Myocardial Ischemia and Infarction

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