Invited commentary: Commentary on Viewpoint article by A H Henderson, M J Lewis, A M Shah, and J A Smith (April, pages 305-8)

Biochemical and clinical relevance of alpha lipoic acid: antioxidant and anti-inflammatory activity, molecular pathways and therapeutic potential

“…Nitric oxide (NO) is a soluble and highly diffusible gas generated by a wide variety of cell types including vascular endothelial cells [27]. Excess production of endogenous NO under inflammatory conditions can be toxic to vascular endothelial cells [54]. Unregulated NO production leads to an increase in reactive nitrogen species (RNS) resulting in nitrosative stress (NS), which may give rise to significant pathological outcomes including cellular injury and disease.…”