(INVITED)Adjustable near-infrared fluorescence lifetime emission of biocompatible rare-earth-doped nanoparticles for in vivo multiplexing

Yao, Jingke; López-Peña, Gabriel; Lifante, José; Cruz, M. Carmen Iglesias-de la; Marin, Riccardo; Jaque, Daniel; Ortgies, Dirk H.

doi:10.1016/j.omx.2022.100225

Cited by 4 publications

(4 citation statements)

References 69 publications

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“…For instance, the combination of density functional theory (DFT), intramolecular energy transfer (IET) theory, and rate equation modelling has enabled researchers to calculate the quantum yield, which is the ratio between absorbed and emitted photons ( Kasprzycka et al, 2020 ; Carneiro Neto et al, 2022 ; Moura et al, 2022b ; Moura et al, 2022c). These theoretical advancements have allowed for the design of lanthanide-based materials with tailored photophysical properties suitable for a wide range of applications, such as optical sensing ( Almeida et al, 2022 ; Ramalho et al, 2022 ), optical thermometry ( Lyubov et al, 2022 ; Salerno et al, 2022 ), bioimaging ( Piñol et al, 2020 ; Yao et al, 2023 ), and light-emitting devices ( Kido et al, 1993 ; Hernández‐Rodríguez et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Eu3+ and Tb3+ coordination compounds with phenyl-containing carbacylamidophosphates: comparison with selected Ln3+ β-diketonates

Kariaka,

Lipa,

Carneiro Neto

et al. 2023

Front. Chem.

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Materials based on Eu3+ and Tb3+ coordination compounds are of great interest due to their strong red and green luminescence. Appropriate selection of ligands plays a huge role in optimizing their photophysical properties. Another very helpful instrument for such optimization is theoretical modelling, which permits the prediction of the emissive properties of materials through intramolecular energy transfer analysis. The ligands that allow for achieving high efficiency of Eu3+ and Tb3+ emissions include carbacylamidophosphates (CAPh, HL). In this brief review, we summarize recent research for lanthanides CAPh-based coordination compounds of general formulas Cat[LnL]4, [LnL3Q] and [Ln(HL)3(NO3)3], where Cat+ = Cs+, NEt4+, PPh4+ and Q = 1,10-phenanthroline, 2,2-bipyridine or triphenylphosphine oxide, involving the use of thermal gravimetric analysis, X-ray analysis, and absorption and luminescence spectroscopy. We carried out a comparison with selected Ln3+ β-diketonates. Possibilities and developments of theoretical calculations on energy transfer rates are also presented.

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Section: Introductionmentioning

confidence: 99%

Eu3+ and Tb3+ coordination compounds with phenyl-containing carbacylamidophosphates: comparison with selected Ln3+ β-diketonates

Kariaka,

Lipa,

Carneiro Neto

et al. 2023

Front. Chem.

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“…461−467 In contrast, lifetime-based fluorescence multiplexing presents the advantage of circumventing uncertainties arising from photon wavelength and spectral overlap, all while acquiring emission peak at the identical wavelength. 58,468 For example, Li et al introduced NaYbF 4 @CaF 2 nanocrystals as NIR τ-dots, capable of efficiently converting pulsed excitation into long-lasting luminescence with nearly 100% emission efficiency. 450 NaYbF 4 @CaF 2 nanocrystals enabled in vivo lifetime imaging with five different channels.…”

Section: Time-resolved Multiplexed Bioimagingmentioning

confidence: 99%

“…Fluorescence multiplexing enables the simultaneous real-time visualization of multiple biological species within a single biological sample, contributing to a deeper understanding of complex organisms . Furthermore, the spectral overlap of fluorophores and significant differences in photon interaction with biological tissues at varying wavelengths can compromise the accuracy of wavelength-based fluorescence multiplexing. − In contrast, lifetime-based fluorescence multiplexing presents the advantage of circumventing uncertainties arising from photon wavelength and spectral overlap, all while acquiring emission peak at the identical wavelength. , …”

Section: Time-resolved Imagingmentioning

confidence: 99%

Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region

Yang,

Jiang,

Zhang

2023

Chem. Rev.

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In vivo imaging technologies have emerged as a powerful tool for both fundamental research and clinical practice. In particular, luminescence imaging in the tissuetransparent near-infrared (NIR, 700−1700 nm) region offers tremendous potential for visualizing biological architectures and pathophysiological events in living subjects with deep tissue penetration and high imaging contrast owing to the reduced light−tissue interactions of absorption, scattering, and autofluorescence. The distinctive quantum effects of nanocrystals have been harnessed to achieve exceptional photophysical properties, establishing them as a promising category of luminescent probes. In this comprehensive review, the interactions between light and biological tissues, as well as the advantages of NIR light for in vivo luminescence imaging, are initially elaborated. Subsequently, we focus on achieving deep tissue penetration and improved imaging contrast by optimizing the performance of nanocrystal fluorophores. The ingenious design strategies of NIR nanocrystal probes are discussed, along with their respective biomedical applications in versatile in vivo luminescence imaging modalities. Finally, thought-provoking reflections on the challenges and prospects for future clinical translation of nanocrystal-based in vivo luminescence imaging in the NIR region are wisely provided.

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“…In the past decades, a variety of rare earth doped nanophosphors with various sizes and morphologies were developed for sensing, anti-counterfeiting, bio-imaging and lighting. Guo et al improved the sensing properties of rare earth doped octahedral microcrystals by tuning phonon energy of matrix [6]. Yao et al construct quantum dots modified NaYF4:Yb 3+ , Ho 3+ nanophosphors for dual-channel anti-counterfeiting ink printing [7] [11].…”

Section: Introductionmentioning

confidence: 99%

Upconversion red light emission and luminescence thermometry of Gd2O3:Er3+ @Gd2O3:Yb3+ core-shell nanofibers synthesized via electrospinning

Liu¹,

Wang²,

Sun³

et al. 2023

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Gd2O3:Er3+@Gd2O3:Yb3+ core-shell nanofibers with cubic phase were successfully fabricated by electrospinning method. The structural, morphological properties were investigated by X-Ray diffraction, scanning electron microscopy. Under 980 nm excitation, the upconversion photoluminescence in visible light exhibits strong red emitting band with obvious splitting peaks resulted from stark splitting of energy level. The visible emissions are sensitive to temperature in the range of 303-543 K. The red emission displays quenching with elevation of temperature. The activation energy for thermal quenching is equal to 0.1408 eV. The temperature dependent multi-peaks of red emission were systematically investigated. Based on valley and peak ratio of I680.31nm/ I683.03nm in upconversion emission spectra, temperature sensing with constant absolute sensitivity was achieved. These results suggest Gd2O3:Er3+@Gd2O3:Yb3+ nanofibers are promising candidates for luminescence thermometry, which may provide their application values in both scientific research and industry.

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(INVITED)Adjustable near-infrared fluorescence lifetime emission of biocompatible rare-earth-doped nanoparticles for in vivo multiplexing

Cited by 4 publications

References 69 publications

Eu3+ and Tb3+ coordination compounds with phenyl-containing carbacylamidophosphates: comparison with selected Ln3+ β-diketonates

Eu3+ and Tb3+ coordination compounds with phenyl-containing carbacylamidophosphates: comparison with selected Ln3+ β-diketonates

Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region

Upconversion red light emission and luminescence thermometry of Gd2O3:Er3+ @Gd2O3:Yb3+ core-shell nanofibers synthesized via electrospinning

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