Invitation Paper (C.P. Alexander Fund): Endocrine Regulation of Male Accessory Gland Development and Activity

Gillott, Cedric; Gaines, Sarah B.

doi:10.4039/ent124871-5

Cited by 30 publications

(17 citation statements)

References 76 publications

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“…Since this pioneering experiment, many authors have confirmed that, for most species, JH is necessary for the full development of secretory activity in the MAG (see reviews by Gillott, 1988;Gillott and Gaines, 1992). What is only now becoming clear, however, is the precise role of JH in production of the secretory components.…”

Section: Endocrine Control Of Mag Secretory Activitymentioning

confidence: 83%

Male insect accessory glands: Functions and control of secretory activity

Gillott

1996

Invertebrate Reproduction & Development

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Paralleling the diversity of the class Insecta, the male accessory glands (MAG) exhibit a wide range of form, and their secretion serves a variety of finctions, including spermatophore and mating plug formation, sperm activation, provision of nutrients to females, and, through production of fecundity-enhancing andlor receptivity-inhibiting substances, modification of female reproductive behavior. In most insects, juvenile hormone (JH) is important in the regulation of MAG secretory activity; specifically, JH controls the production of particular proteins in the secretion. However, the production of some proteins appears not to be influenced by JH; rather, their synthesis is regulated by ecdysteroids. During sexual maturation, JH and ecdysteroids seem to interact to bring about a specified temporal sequence of protein synthesis in the MAG.

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Section: Endocrine Control Of Mag Secretory Activitymentioning

confidence: 83%

Male insect accessory glands: Functions and control of secretory activity

Gillott

1996

Invertebrate Reproduction & Development

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“…3B), showing a limited response to very low doses (0.01-0.1 pg) and an additional response to doses above 1 pg, suggests two phases to the action of JH within this organ. These may correspond to the two JH effects observed in the accessory gland of M. sanguinipes, which responded to JH I11 during 4 h in vitro by increased synthesis of a specific protein only if the tissue was previously exposed in vivo to JH (Gillott and Gaines, 1992). Two phases of JH action, described as activation and regulation, have been observed in the induction of vitellogenin synthesis and other JH regulated events in adult insects, where an initial exposure to JH is required to render the cells competent for a subsequent definitive response (Davey, 1994).…”

Section: Discussionmentioning

confidence: 99%

“…Growth of the gland in adult locusts occurs without cell division, and weight gains represent cell enlargement and accumulation of secretions (Lange and Loughton, 1984). In the accessory gland of the grasshopper, Melanoplus sanguinipes, protein synthesis is reduced by allatectomy and restored by application of JH (Venkatesh and Gillott, 1983;Gillott and Gaines, 1992).…”

Section: Introductionmentioning

confidence: 99%

“…The reproductive accessory glands of male insects vary widely in morphology but perform a set of functions that are comparable in many species (reviews: Happ, 1992;Kaulenas, 1992;Gillott and Gaines, 1992). They contain tubules of several types which are active in the synthesis of many different proteins that are secreted from the cells and accumulate in the lumen to serve as components of the spermatophore and seminal fluid.…”

Section: Introductionmentioning

confidence: 99%

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Growth of the male accessory gland in adult locusts: Roles of juvenile hormone, JH esterase, and JH binding proteins

Braun

Wyatt

1995

Arch Insect Biochem Physiol

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The participation of juvenile hormone (JH) in the regulation of growth and protein synthesis in the accessory reproductive gland of male Locusta rnigratoria has been investigated. After elimination of endogenous J H with ethoxyprecocene, the accessory gland failed to grow, but growth was restored by a single application of the J H analog, pyriproxyfen. Pyriproxyfen appeared to stimulate total protein synthesis by 3 h, with a significant effect by 12 h, in contrast to 24 h observed in fat body. The dose curve for stimulation of protein synthesis 12 h after applying pyriproxyfen gave an ED50 of 0.1 pg; the dose curve for gland growth at 72 h was biphasic, with steps at about 0.01 pg and 10 pg, suggesting two phases in J H action. SDS-PAGE analysis showed several components that were stimulated by pyriproxyfen, the effect being strongest in an 11 kDa band. A 5 kDa component was enhanced in the soluble and reduced in the particulate fraction after precocene treatment. The accessory gland contained J H esterase activity at levels about 100 times those in fat body or hemolymph, and was higher in precocene treated locusts. Binding activity for [3H] 1 OR-JH Ill was high in cytosolic and nuclear fractions, and was identified immunologically as due to the previously described hemolymph J H binding protein. The results indicate that the mode of action of J H in the accessory gland may differ from that in the fat body. The presence of intracellular J H binding protein suggests a direct action of J H within the gland, that may be modulated by J H eSteraSe. 0 1995 Wiley-Liss, Inc.

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“…Isolated abdomens also produce ecdysteroid, though the exact source is not known (Sakurai et al, 1991 ;Jenkins et al, 1992). In most insects juvenile hormone (JH) and 20-HE are important in the development of the MARG (Gillott and Gaines, 1992). In the MARG of the migratory grasshopper, Melanoplus sanguinipes, JH regulates the synthesis of some specific proteins (e.g., LHPI in the long hyaline tubule) (Cheeseman and Gillott, 1988) though the synthesis of others seems to be unaffected by this hormone (Venkatesh and Gillott, 1983).…”

Section: Introductionmentioning

confidence: 97%

In vitrosynthesis of ecdysteroid by the male accessory reproductive glands, testis and abdominal integument of the adult migratory grasshopper,Melanoplus sanguinipes

Gillott

Ismail

1995

Invertebrate Reproduction & Development

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Invertebrate Reproduction and Development, 27: 1 (1995) 65-71 Balaban, PhiladelphiaIRehovot 0168-8170/95/$05.00 O 1995 BalabanIn vitro synthesis of ecdysteroid by the male accessory reproductive glands, testis and abdominal integument of the adult migratory grasshopper, Melanoplus sanguinipes SummaryMale accessory reproductive glands (MARG), testis (including its sheath) and abdominal integument along with adhering fat body were cultured in vitro to determine their ability to synthesize ecdysteroid during the first 10 days of adult development. Ecdysteroid synthesis by MARG was highest on day 2 (0.180 nglmg) while the testis showed a peak on day 5 (0.436 nglmg). In the testis, the sheath is mainly responsible for ecdysteroid synthesis. Ecdysteroid is also synthesized by the abdominal integument with adhering fat body, and peak activity is observed on day 8 (0.50 nglmg). A time-course study showed that ecdysteroid synthesis increased linearly in all tissues over a 24-h incubation period. However, little storage of ecdysteroid occurred in the tissues.

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Invitation Paper (C.P. Alexander Fund): Endocrine Regulation of Male Accessory Gland Development and Activity

Cited by 30 publications

References 76 publications

Male insect accessory glands: Functions and control of secretory activity

Male insect accessory glands: Functions and control of secretory activity

Growth of the male accessory gland in adult locusts: Roles of juvenile hormone, JH esterase, and JH binding proteins

In vitrosynthesis of ecdysteroid by the male accessory reproductive glands, testis and abdominal integument of the adult migratory grasshopper,Melanoplus sanguinipes

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