Investigator® HDplex (Qiagen) reference population database for forensic use in Argentina

Evaluation of forensic genetic parameters of 12 STR loci in the Korean population using the InvestigatorⓇ HDplex kit

“…These 20 loci are considered to provide sufficient genetic information for forensic analyses [1][2][3]. However, additional STR loci may be required to supplement and support scientific conclusions and increase the reliability of the genetic results, particularly in more difficult cases like kinship analyses [2,4].…”

“…The Investigator Ⓡ HDplex kit (QIAGEN, Hilden, Germany) was developed to discriminate between related individuals for specific forensic applications and paternity testing, is complementary to the core STR markers [2,5]. Forensic genetic studies using the Investigator Ⓡ HDplex kit have been performed in different laboratories [2,[4][5][6][7][8].…”

“…Forensic genetic studies using the Investigator Ⓡ HDplex kit have been performed in different laboratories [2,[4][5][6][7][8]. To date, the use of the Investigator Ⓡ HDplex kit to calculate the forensic genetic parameters of the Korean population has not been reported.…”

“…Calculations of allele frequencies, observed and expected heterozygosity, the values of Fst, and pairwise p values for the pairwise comparison of genetic distances in Korean and other populations were performed using Arlequin v3.5. Allele frequencies were obtained from published population data including Argentinian [2], North Italian [4], Dutch [6], Japanese [7], and Shanghai Han [8] populations. The population genetics parameters including matching probability (PM), power of discrimination (PD), polymorphism information content (PIC), and power of exclusion (PE) were calculated using PowerStats v1.…”

“…2 [9]. D7S1517, D10S2325, and D21S2055 loci that showed tri-allelic patterns in the samples were removed prior to statistical analysis [2].…”