Investigative Studies with the Laser in the Treatment of Basal Cell Epitheliomas

Goldman, L; Rj, Rockwell; Meyer, R.A.; Otten, Richard F.

doi:10.1097/00007611-196807000-00015

Cited by 19 publications

(9 citation statements)

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“…6 Intralesional interferon (IFN)-␣ has also been reported for the treatment of BCC. 7,8,[15][16][17][18] Lasers have been combined with curettage. Although reports of eradication of small superficial and nodular BCCs have been noted, this therapy is limited by local irritation and erythema of the treated areas, and the relative high cost of the medication.…”

Section: Discussionmentioning

confidence: 99%

Ultrapulse CO2 Used for the Successful Treatment of Basal Cell Carcinomas Found in Patients with Basal Cell Nevus Syndrome

Nouri

Chang

Trent

et al. 2002

Dermatologic Surgery

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background. Basal cell nevus syndrome (BCNS) is an inherited condition marked by multiple basal cell carcinomas (BCCs) associated with several other abnormalities. Various treatment modalities have been used to eradicate these tumors. However, recurrences and scarring limit their use. objective. To evaluate the treatment of multiple BCCs associated with BCNS. methods. We describe three cases of BCNS in which multiple BCCs were effectively treated with ultrapulse CO 2 laser. Post-operative Mohs micrographic surgical sections (thin sections looking for residual tumor) verified complete histologic clearance of the tumors. results. All three patients were effectively treated with ultrapulse CO 2 laser. Minimal scarring was noted at follow-up. conclusion. Ultrapulse CO 2 laser can be used to effectively treat small BCCs in low-risk areas associated with BCNS with minimal posttreatment scarring.

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Section: Discussionmentioning

confidence: 99%

Ultrapulse CO2 Used for the Successful Treatment of Basal Cell Carcinomas Found in Patients with Basal Cell Nevus Syndrome

Nouri

Chang

Trent

et al. 2002

Dermatologic Surgery

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“…47 Dr. Leon Goldman, in 1963, initiated the use of the laser for the medical treatment of skin by applying the ruby laser to a variety of cutaneous conditions. 48,49,50 Over the next 20 years, CO 2 and argon lasers were developed and were used as the primary means to treat skin conditions. Argon was able to address vascular lesions and CO 2 was used for tissue vaporization and destruction of skin pathologies; however, both had high rates of unacceptable scarring when used on the skin primarily because of the nonspecific, global, uncontrolled injury that was caused.…”

Section: Laser Resurfacingmentioning

confidence: 99%

1 The History and Evolution of Skin Resurfacing

Truswell¹

2016

Lasers and Light, Peels and Abrasions

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“…48 Compared to traditional surgical management, laser therapy offers a less invasive procedure, often with an improved cosmetic outcome. Furthermore, lasers are useful in anatomical locations where distortion may occur with surgery.…”

Section: The Use Of Lasers For Skin Pathologymentioning

confidence: 99%

18 The Use of Lasers for Skin Pathology

Truswell¹

2016

Lasers and Light, Peels and Abrasions

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The use of lasers for skin pathology has grown dramatically since their initial introduction several decades ago. The quantum theory of radiation, described nearly a century ago, served as the theoretical foundation for the development of lasers. Yet it was not until 1959 that Maiman developed the first laser 1 and later, in 1963, when Dr. Leon Goldman pioneered laser therapy for the field of dermatology by treating various cutaneous conditions with his ruby laser. Laser therapy was further revolutionized when Anderson and Parrish introduced the theory of selective photothermolysis, promoting the selective destruction of targets in the skin without unwanted surrounding thermal damage. 2 Thereafter, advancements in technology, increased ease of operation, and decreased side effects boosted the popularity of laser therapy for cutaneous disease. Although not inclusive of all skin pathologies amenable to laser therapy, this chapter focuses on the laser treatment for hyperpigmented lesions, benign skin lesions, and basal cell carcinomas (BCCs). AnatomyMelanin, hemoglobin, and water are the three chromophores targeted in skin-directed laser therapy. In normal skin, melanin is produced by melanocytes, transferred to keratinocytes, and confined to the epidermis. Hemoglobin is carried within red blood cells that circulate within blood vessels located in the dermis. Water is present in all layers of the skin but is increased in abundance in the dermis and subcutaneous tissue. Melanin, hemoglobin, and water each exhibit characteristic wavelengths of absorption. Exposure to these energy wavelengths induces excitation to a higher energy state. Lasers with corresponding wavelengths selectively target these chromophores to treat cutaneous pathology while limiting surrounding tissue damage. Hyperpigmented LesionsThe pathogenesis of skin hyperpigmentation is complex. A single or combination of factor(s) such as photosensitivity, trauma, medication deposition, or neoplasia may result in the clinical observation of skin hyperpigmentation. The classification and treatment of pigmentary disorders is based upon the histological location of the pigment within the epidermis, dermis, or a combination of both the epidermis and dermis. Due to melanin's wide spectrum of absorption, several lasers may be used to target this pigment. Ideal laser therapy targets the abnormal pigment without causing surrounding damage. In general, longer wavelength lasers penetrate deeper in the skin. 3 Thus lasers with a shorter wavelength are commonly utilized for superficial pigmented lesions, whereas the longer wavelength lasers are employed for dermal pigmentation.Continuous wave and quasicontinuous wave laser systems were the first laser systems implemented to treat pigmentary disorders. However, the pulse duration of these laser systems is longer than the thermal relaxation time of the melanosome, resulting in significant surrounding thermal damage with subsequent scarring and dyspigmentation. 4 More recently, shortpulsed or quality-switched (QS) lasers ...

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Investigative Studies with the Laser in the Treatment of Basal Cell Epitheliomas

Cited by 19 publications

References 0 publications

Ultrapulse CO2 Used for the Successful Treatment of Basal Cell Carcinomas Found in Patients with Basal Cell Nevus Syndrome

Ultrapulse CO2 Used for the Successful Treatment of Basal Cell Carcinomas Found in Patients with Basal Cell Nevus Syndrome

1 The History and Evolution of Skin Resurfacing

18 The Use of Lasers for Skin Pathology

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