Investigations to Evaluate Gastric Mucoadhesion of an Organic Product to Ameliorate Gastritis

Winter, Christina; Hartl, Sonja; Kolb, Dagmar; Leitinger, Gerd; Roblegg, Eva

doi:10.3390/pharmaceutics12040331

Cited by 4 publications

(3 citation statements)

References 53 publications

(107 reference statements)

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“…The in vitro comparison was performed with the modified falling liquid film technique as previously described by Winter et al The in vivo MRI study was performed with iron oxide as a transit and disintegration marker, which has been successfully established in previous studies. − …”

Section: Discussionmentioning

confidence: 99%

“…The interaction of adhesive and non-adhesive formulations with gastric mucoglycoproteins (i.e., mucin) was investigated on a modified falling liquid film technique as previously described by Winter et al . For this purpose, glass cover slides (25 mm diameter) were coated with 5% (w/w) porcine stomach mucin type III dispersed in water (Sigma-Aldrich, Germany).…”

Section: Methodsmentioning

confidence: 99%

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In Vitro and In Vivo Evaluation of Carbopol 71G NF-Based Mucoadhesive Minitablets as a Gastroretentive Dosage Form

et al. 2023

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Gastroretentive dosage forms are intended to stay inside the stomach for a long period of time while releasing an active pharmaceutical ingredient. Such systems may offer significant benefits for numerous drugs compared to other sustained release systems, such as improved pharmacokinetics/ bioavailability and reduced intake frequency and thereby improved adherence to the medical therapy. However, there is no gastroretentive product on the market with proven reliable gastroretentive properties in humans. A major obstacle is the motility pattern of the stomach in the fasting state in humans, which reliably ensures gastric emptying of even large indigestible objects into the small intestine. One promising approach to avoid gastric emptying is adhesion of the drug delivery system to the gastric mucosa. In order to achieve mucoadhesive properties, minitablets containing Carbopol 71G NF were developed and compared to minitablets without adhesive properties. In a specialized mucoadhesive test system, the adhesion time was prolonged for adhesive minitablets (240 min) compared to non-adhesive minitablets (30 min). The in vivo transit behavior was investigated using magnetic resonance imaging in 11 healthy volunteers in fasted state in a crossover setup. It was found that the gastric residence time (GRT) of the adhesive minitablets (median of 37.5 min with IQR = 22.5−52.5) was statistically significantly prolonged compared to the non-adhesive minitablets (median of 7.5 with IQR = 7.5−22.5), indicating a delay in gastric emptying by adhesion to the gastric mucosa. However, the system needs further improvement to create a clinical benefit. Furthermore, it was observed that for 9 of 22 administrations (three minitablets were given simultaneously with every administration), the minitablets were not emptied together but showed different GRTs.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

In Vitro and In Vivo Evaluation of Carbopol 71G NF-Based Mucoadhesive Minitablets as a Gastroretentive Dosage Form

et al. 2023

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“…Gastritis is an inflammatory disease that affects the lining of the stomach mucosa 1 . Haematemesis or melaena may appear in young children 2 .…”

Section: Introductionmentioning

confidence: 99%

Retrospective study on endoscopic findings of gastritis in children attending the gastrointestinal tract endoscopic unit of Assiut University Children Hospital over a 15-year-period

Abu Faddan,

Reyad,

Shalaby

2023

Sri Lanka J Child Health

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Background: Children with gastritis typically exhibit recurrent stomach pain and dyspepsia or vomiting.Objectives: To assess the frequency, clinical manifestations, endoscopic pictures, aetiology and outcome of gastritis in children who visited the gastrointestinal tract (GIT) endoscopic unit of Assiut University Children Hospital.Method: This was a retrospective, crosssectional study conducted at Assiut University Children Hospital GIT Endoscopic Unit from 1st January 2005 to 31st December 2019.Results: Upper GI endoscopy, done in all cases, showed that 66 (8.1%) had erythematous gastric mucosa, 106 (13%) had nodular gastric mucosa, 212 (25.9%) had erythematous gastric mucosa and hyperaemia, 147 (18%) had erythematous gastric mucosa and nodularity, 156 (19.1%) had hyperaemic mucosa and petechiae, 77 (9.5%) had hyperaemic mucosa and erosion, and 53 (6.5%) had multiple erosions and ulcers.Conclusions: Gastritis represented 9.4% of children who underwent upper GI endoscopy. Helicobacter pylori was the commonest cause with high recurrence. Patients presented with recurrent GI bleeding, and those with erythematous hyperaemic mucosa on endoscopy showed recurrence compared to their counterparts.

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Ex vivo evaluation of adhesive strength and barrier effect of a novel treatment for esophagitis

Brito‐Casillas

Caballero

Hernández-Baraza

et al. 2023

Gastroenterología y Hepatología (English Edition)

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Investigations to Evaluate Gastric Mucoadhesion of an Organic Product to Ameliorate Gastritis

Cited by 4 publications

References 53 publications

In Vitro and In Vivo Evaluation of Carbopol 71G NF-Based Mucoadhesive Minitablets as a Gastroretentive Dosage Form

In Vitro and In Vivo Evaluation of Carbopol 71G NF-Based Mucoadhesive Minitablets as a Gastroretentive Dosage Form

Retrospective study on endoscopic findings of gastritis in children attending the gastrointestinal tract endoscopic unit of Assiut University Children Hospital over a 15-year-period

Ex vivo evaluation of adhesive strength and barrier effect of a novel treatment for esophagitis

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