Investigations on the use of testosterone oenanthate as a male contraceptive agent

Mauss, J; Börsch, G; Richter, Elke; Bormacher, K.

doi:10.1016/0010-7824(74)90006-7

Cited by 28 publications

(5 citation statements)

References 12 publications

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“…It is possible to inhibit sperm production indirectly by suppressing the secretion of testosterone (T), which is required for spermatogenesis. This has been achieved variously by using exogenous androgens [1][2][3][4][5] to inhibit the release of LH, and by blocking the action of GnRH [6][7][8][9][10][11][12]. However, drugs such as gossypol [13][14][15], tolnidamine [16], and sulfasalazine [17][18][19][20][21] can also directly inhibit spermatogenesis.…”

Section: Introductionmentioning

confidence: 99%

Maintenance of Sexual Function with Testosterone in the Gonadotropin-Releasing Hormone-Immunized Hypogonadotropic Infertile Male Rat

Awoniyi¹,

Reece²,

Hurst³

et al. 1993

Biology of Reproduction

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We have previously shown that active immunization against GnRH in the mature male rat can predictably produce hypogonadotropic hypogonadism and azoospermia and, further, that normospermia and normal fertility can be restored by testosterone (T) administration alone. The objective of this study was to explore the hypothesis that GnRH-immunized azoospermic rats could be supplemented with T doses sufficient to restore sexual behavior, but insufficient to support adequate spermatogenesis or to allow restoration of fertility. Adult male rats of proven fertility were immunized against GnRH and supplemented with 2-, 4-, or 8-cm T implants or with empty implants. Eight weeks later, fertility was evaluated; concentrations of serum T, LH, FSH, growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) were determined; sperm number was obtained from the testis; and weights of androgen-dependent organs were measured. GnRH immunization and T supplementation resulted in restoration of organ weights and of fertility in a dose-dependent manner. GnRH immunization with or without T supplementation resulted in the absence of circulating gonadotropins, but had no effect on serum GH, PRL, or TSH levels. Whereas all control animals were fertile, rats that received either empty or 2-cm T implants were completely infertile. Rats that received 4-cm or 8-cm T implants were fertile in 60% and 100% of cases, respectively. Sexual behavior of rats with empty and with 2-cm T implants was compared at 10-18 wk after immunization with GnRH. GnRH-immunized rats given empty implants displayed negligible sexual activity, but those with 2-cm T implants displayed sexual activity equivalent to that of untreated controls despite complete infertility.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Introductionmentioning

confidence: 99%

Maintenance of Sexual Function with Testosterone in the Gonadotropin-Releasing Hormone-Immunized Hypogonadotropic Infertile Male Rat

Awoniyi¹,

Reece²,

Hurst³

et al. 1993

Biology of Reproduction

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“…A marked reduction in sperm count occurred in eight fertile men with a 40–50 mg testosterone implant and an oral dose of 50 mg norgestrionone or R‐2323 three times weekly, but similar results were not obtained with the testosterone implant plus 50 mg NET 9 . Oral administration of NET or megestrol acetate concomitant with testosterone implant therapy was capable of reducing the sperm count to azoospermia in 6–12 weeks 11 . However, daily oral administration of 20 mg norethandrolone, a derivative of NET, for four months to volunteers having testosterone implants failed adequately to suppress spermatogenesis 12 .…”

Section: Steroidal Regimens and Their Effect On Seminal Parametersmentioning

confidence: 83%

“…Marked recovery up to 63 mill/ml did not occur until 17 weeks after stopping treatment. Changes in normal morphology and motility of spermatozoa varied according to the sperm concentration, while the semen volume remained the same 11,13 . Weekly or biweekly injections of 200 mg TE in 39 men for 16–20 weeks suppressed sperm production to less than 5 mill/ml in most subjects, while a few became azoospermic.…”

Section: Steroidal Regimens and Their Effect On Seminal Parametersmentioning

confidence: 95%

Steroidal Contraception for Men

Sarkar

2000

Int J Clinical Practice

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SUMMARYThis article is a review of the development of male steroidal contraceptives during the past 25 years. Numerous studies have been conducted on male volunteers with oral and/or injectable preparations of single or combined steroids. Progestogen, androgen alone, or progestogen and androgen combinations have been used as weekly or monthly injectable formulations. Most of the studies involved small numbers of subjects. There was reversible suppression of spermatogenesis to oligospermia and/or azoospermia during the treatment period. Alteration of LH, FSH and testosterone levels in the blood was observed in most of these studies, depending on the steroid or combination of steroids used. There were reports about decreased or increased libido and weight gain during treatment with steroids. No other serious side‐effects were found. Attention has recently focused on developing an androgen‐only male contraceptive, because testosterone ester has shown promising results. The development of an effective and reliable steroidal contraceptive for men may be possible but this requires further research.

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“…Recently published reports described investigations with testosterone oenanthate (Toe: Testoviron (R) Depot, Schering AG Berlin) aimed at the reversible inhibition of fertility in young men (Mauss et al -1974;Mauss et al -1975;Borsch et al -1975).…”

Section: Introductionmentioning

confidence: 99%

Demonstration of the Reversibility of Spermatozoa Suppression by Testosterone Oenanthate

et al. 2009

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Zusammenfassung Nachweis der Reversibilität der Spermatozoensuppression durch Testosteronönanthat 7 gesunde junge Probanden waren langfristig mit Testosteronönanthat behandelt worden mit dem Ziel, die Spermatogenese reversibel zu hemmen. Nach Absetzen der Therapie trat in der anschließenden Nachbeobachtungsperiode eine allmähliche Erho‐lung der Spermatogenese ein. Bei drei der Probanden erreichten die Spermatozoenzahlen jedoch nicht das Vorbehandlungsniveau. 3 Jahre nach Versuchsbeginn, d.h. 2,5 Jahre nach der letzten Testosteronönanthatinjektion wurden die Probanden nochmals nachuntersucht. Dabei ergab sich, daß die Testosteronbehandlung zu keiner erkennbaren negativen Beeinflussung der Hodenfunktion geführt hat. Bei drei Probanden zeigten die Spermaanalysen sogar höhere Spermatozoenzahlen als vorher.

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Investigations on the use of testosterone oenanthate as a male contraceptive agent

Cited by 28 publications

References 12 publications

Maintenance of Sexual Function with Testosterone in the Gonadotropin-Releasing Hormone-Immunized Hypogonadotropic Infertile Male Rat

Maintenance of Sexual Function with Testosterone in the Gonadotropin-Releasing Hormone-Immunized Hypogonadotropic Infertile Male Rat

Steroidal Contraception for Men

Demonstration of the Reversibility of Spermatozoa Suppression by Testosterone Oenanthate

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