Investigations on the Ability of the Insular Cortex to Process Peripheral Immunosuppression
Julia Bihorac,
Yasmin Salem,
Laura Lückemann
et al.
Abstract:The brain and immune system communicate through complex bidirectional pathways, but the specificity by which the brain perceives or even remembers alterations in immune homeostasis is still poorly understood. Recent data revealed that immune-related information under peripheral inflammatory conditions, termed as “immunengram”, were represented in specific neuronal ensembles in the insular cortex (IC). Chemogenetic reactivation of these neuronal ensembles was sufficient to retrieve the inflammatory stages, indi… Show more
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