Investigations on integration of mossy fiber inputs to Purkyně cells in the anterior lobe

Jc, Eccles; Faber, Donald S.; Jt, Murphy; Nh, Sabah; Táboríková, H

doi:10.1007/bf00236430

Cited by 75 publications

(35 citation statements)

References 36 publications

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“…Thus far from suggesting that parallel fibers play no role in PC response properties, we have simply proposed a different, more subtle and complex role. This is essentially the same conclusion drawn by Eccles and colleagues in 1971, when they first failed to find a beam-like parallel fiber activation of PCs after natural tactile stimulation (Eccles et al 1971). …”

Section: Functional Significancesupporting

confidence: 85%

“…Based on most interpretations of the granule cell-PC circuitry (Ito 2001), it might seem logical to assume that these spikes are "driven" by activity in the parallel fibers. However, as already discussed, this interpretation is not consistent with numerous in vivo studies that have failed to demonstrate a direct excitatory relationship between parallel fiber activity and PC output (Bell and Grimm 1969;Bower and Woolston 1983;Cohen and Yarom 1998;Eccles et al 1971;Kolb et al 1997). Instead, it is most likely that PCs themselves intrinsically generate spiking activity as suggested by the presence of spontaneous activity in vitro (Llinas and Sugimori 1980a,b) and in tissue culture preparations (Linden et al 1991;Schilling et al 1991).…”

Section: Underlying Gcl Activity Does Not Account For All Pc Spikesmentioning

confidence: 85%

“…In almost all cases, theorists have assumed that the timing of PC simple spikes is under the direct control of the up to 150,000 parallel fiber synapses each cell receives. However, experimental evidence dating back to the 1960s suggests that this might not be the case (Bell and Grimm 1969;Bower and Woolston 1983;Cohen and Yarom 1998;Eccles et al 1971;Kolb et al 1997). Instead it was proposed more than 20 years ago that synapses associated with the ascending segment of the granule cell axon, but not the parallel fiber, most directly influence PC spiking (Bower and Woolston 1983;Llinas 1982).…”

Section: Introductionmentioning

confidence: 99%

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Correlations Between Purkinje Cell Single-Unit Activity and Simultaneously Recorded Field Potentials in the Immediately Underlying Granule Cell Layer

Hartmann²,

Bower

2005

Journal of Neurophysiology

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Lu, Huo, Mitra J. Hartmann, and James M. Bower. Correlations between Purkinje cell single-unit activity and simultaneously recorded field potentials in the immediately underlying granule cell layer. J Neurophysiol 94: 1849 -1860, 2005. First published May 31, 2005 doi:10.1152/jn.01275.2004. Evidence from both anatomical and physiological studies suggests that the ascending segment of the granule cell axon provides a large, driving input to overlying Purkinje cells. In the current experiments, we used dual recording electrodes to simultaneously record spike activity of Purkinje cells and multiunit field potential activity in the directly underlying granule cell layer. These dual recordings were performed both during periods of spontaneous ("background") firing and also after peripheral tactile stimulation. The results demonstrate that in the large majority of cases, there is a strong positive correlation between spontaneous Purkinje cell simple spikes and spontaneous activity in the immediately underlying granule cell layer. The strength of this correlation was dependent on both the firing rate of the Purkinje cell as well as on the rate of granule cell layer multiunit activity. In addition, for any given pair of recordings, the correlation seen during spontaneous activity accurately predicted the magnitude and time course of responses evoked by peripheral tactile stimulation. These results provide additional evidence that the synapses associated with the ascending segment of the granule cell axon have a substantial influence on Purkinje cell output. This relationship is considered in the context of our ongoing reevaluation of the physiological relationship between cerebellar granule and Purkinje cells. I N T R O D U C T I O NThe unusual and geometrically stereotyped relationship between the parallel fiber axonal system and the Purkinje cells (PCs) has strongly influenced cerebellar theories for more than 50 years (Albus

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Section: Functional Significancesupporting

confidence: 85%

Section: Underlying Gcl Activity Does Not Account For All Pc Spikesmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

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Correlations Between Purkinje Cell Single-Unit Activity and Simultaneously Recorded Field Potentials in the Immediately Underlying Granule Cell Layer

Hartmann²,

Bower

2005

Journal of Neurophysiology

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“…While the evidence that parallel fibers don't directly drive Purkinje cell output under more natural stimulation conditions dates back more than 40 years (Eccles et al 1972a), it has only been fairly recently that a plausible explanation for this result has been obtained, and this understanding is the result of an interplay between experimental studies and a very different kind of modeling effort than that envisioned by Marr, and represented by most existing models of cerebellar cortical function. The rest of this chapter lays the groundwork for this different approach to unraveling the computational structure of the cerebellum which relies on the construction of models that include as much anatomical and physiological detail as possible, but explicitly do not include more overarching functional assumptions.…”

Section: Uncovering Function From Structurementioning

confidence: 99%

Computational Structure of the Cerebellar Molecular Layer

Bower¹

2013

Handbook of the Cerebellum and Cerebellar Disorders

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Theories regarding the computational structure of the cerebellar molecular layer have been more strongly influenced by biological data than is the case for many and perhaps even most other vertebrate brain regions. Yet, or perhaps for this reason, the computational significance of this circuitry remains a very active subject of discussion and debate, with even basic assumptions regarding the physiological organization of this circuit now being questioned. Specifically, while most current models of molecular layer circuitry assume that parallel fiber excitatory synaptic input directly drives Purkinje cells to fire, there is growing experimental evidence that this might not be the case. Recent model-based efforts to better understand the functional role of the parallel fiber system suggest that molecular layer inhibition may play a larger and more complex physiological role than previously realized. In turn, this reanalysis of the role of inhibition in cerebellar cortical circuitry suggests that the cerebellar molecular layer may implement a sensory-related contextual algorithm, rather than either a timing or associative learning function previously assumed to provide the basis for a cerebellar involvement in motor coordination.

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“…Therefore it was suggested that Purkyn6 cells might integrate specific subsets of sensory inputs (Eccles et at. 1969(Eccles et at. , 1971.…”

Section: Introductionmentioning

confidence: 99%

Synaptic actions of peripheral nerve impulses upon Deiters neurones via the climbing fibre afferents

Allen¹,

Sabah²,

Toyama³

1972

The Journal of Physiology

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Investigations on integration of mossy fiber inputs to Purkyně cells in the anterior lobe

Cited by 75 publications

References 36 publications

Correlations Between Purkinje Cell Single-Unit Activity and Simultaneously Recorded Field Potentials in the Immediately Underlying Granule Cell Layer

Correlations Between Purkinje Cell Single-Unit Activity and Simultaneously Recorded Field Potentials in the Immediately Underlying Granule Cell Layer

Computational Structure of the Cerebellar Molecular Layer

Synaptic actions of peripheral nerve impulses upon Deiters neurones via the climbing fibre afferents

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