Investigations on biodistribution of technetium-99m-labeled carbohydrate-coated poly(propylene imine) dendrimers

Agashe, Hrushikesh; Babbar, Anil Kumar; Jain, Sanyog; Sharma, Rakesh Kumar; Mishra, Anil K.; Asthana, Abhay; Garg, Minakshi; Dutta, Tathagata; Jain, Narendra Kumar

doi:10.1016/j.nano.2007.02.002

Cited by 61 publications

(48 citation statements)

References 41 publications

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“…PAMAMOS dendrimers offer unique potential for novel application in electronics, chemical catalysis, nano-lithography, photonics, etc. It is possible due to its unique properties such as constancy of structure and ability to form complex and encapsulate various guest species with nanoscopic topological precision [89].…”

Section: ) Pamam-organosilicon (Pamamos) Dendrimersmentioning

confidence: 99%

See 1 more Smart Citation

Nanotechnology and its implications in therapeutics

Patil¹,

Chaudhary²,

Jadhav³

et al. 2015

Nano Based Drug Delivery

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Section: ) Pamam-organosilicon (Pamamos) Dendrimersmentioning

confidence: 99%

“…The devices are designed to work together, monitor the body's glucose levels and automatically pump appropriate doses of insulin as determined by a computer algorithm [89]. The development of an artificial pancreas could be the permanent solution for diabetic patients.…”

Section: Artificial Pancreasmentioning

confidence: 99%

Nanotechnology and its implications in therapeutics

Patil¹,

Chaudhary²,

Jadhav³

et al. 2015

Nano Based Drug Delivery

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“…By contrast, conjugation of lactose to dendrimers increased uptake via the liver and spleen (Agashe et al 2007). It is therefore clear that galactose promotes cellular targeting towards hepatocytes, whereas mannose specifically targets liver and spleen resident macrophages after intravenous dosing.…”

Section: Presentation Of Ligands To Organs Of the Reticuloendothelialmentioning

confidence: 99%

Nanosized Drug Delivery Vectors and the Reticuloendothelial System

Kaminskas

Boyd

2011

Intracellular Delivery

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Nanomaterials have potential as drug delivery vectors that can improve the chemical stability and pharmacokinetic profile of small molecule drugs or improve drug uptake into solid tumours. However, one consequence of the use of nanosized drug delivery vectors is their potential recognition by tissue macrophages and accumulation in organs of the reticuloendothelial system (RES). While in some instances the uptake of drug loaded nanomaterials or 'nanomedicines' into organs of the RES is favoured, in most instances uptake into the RES can limit systemic exposure of the nanomedicine and limit therapeutic utility. Hence, this section discusses ways in which the RES uptake of nanomedicines can either be promoted or inhibited. Specifically, the effect of various physicochemical properties and presence or absence of key RES 'recognition ligands' on RES uptake are examined.

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“…In fact, Agashe et al [94] directly labeled PPI dendrimers with 99m Tc-pertechnetate and SnCl 2 and proved that the label was stably attached to the NPs both in vitro and in vivo. Similarly, Park and co-workers did not observe any release of 99m Tc-pertechnetate after intratumor injection of directly 99m Tc-labeled pullulan NPs [95].…”

Section: Technetium and Rhenium Radiolabelingmentioning

confidence: 99%

Radiolabeled Nanoplatforms: Imaging Hot Bullets Hitting their Target

Rossin

2011

Nanoplatform‐Based Molecular Imaging

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Nanomedicine is a rapidly evolving field. Every year, new and more sophisticated nanoplatforms (NPs) designed to deliver drugs to specific targets or for molecular imaging of disease states make their appearance on the scientific scene. The assessment of the in vivo distribution of these NPs is the first step in order to fully understand their potential as candidate nanomedicines and to predict and prevent toxic side effects. To this aim, the incorporation of a radionuclide in the NP is of great advantage, as radiometric assays are rapid and quantitative. Furthermore, noninvasive nuclear imaging techniques are highly sensitive, achieve high tissue penetration and good spatial resolution, and can accelerate the translation of new NPs into the clinic. This chapter gives an overview of the strategies to label NPs with a variety of radionuclides (radiometals and radiohalogens), focusing on some of the hurdles that scientists must overcome (or take into consideration) when administering these radioconjugates in vivo. Furthermore, the latest achievements in molecular imaging of angiogenesis with radiolabeled NPs are reviewed.The most recent publications on nanoplatforms labeled with ␥ -and ␤ + -emitting radionuclides for SPECT and PET imaging are reviewed. Different strategies to label nanoplatforms are described, particularly those involving radiometals ( 64 Cu, 111 In, 67/68 Ga, 86 Y, 99m Tc, and 186/188 Re) and radiohalogens ( 123/124/125/131 I, 76 B, and 18 F). Some of the problems occurring when evaluating radiolabeled nanoplatforms in vivo are also covered. Finally, the use of radiolabeled nanoplatforms for angiogenesis imaging with PET and SPECT is discussed.

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Investigations on biodistribution of technetium-99m-labeled carbohydrate-coated poly(propylene imine) dendrimers

Cited by 61 publications

References 41 publications

Nanotechnology and its implications in therapeutics

Nanotechnology and its implications in therapeutics

Nanosized Drug Delivery Vectors and the Reticuloendothelial System

Radiolabeled Nanoplatforms: Imaging Hot Bullets Hitting their Target

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