Investigations of ‘transfer factor’ activity in immunity to Ostertagia circumcincta and Trichostrongylus colubriformis infections in sheep

Ross, J. G.; Halliday, W.G.

doi:10.1016/0020-7519(79)90075-4

Cited by 9 publications

(3 citation statements)

References 10 publications

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“…In the two successful investigations to be reported dialysed and non-dialysed TF preparations were prepared by freezing and thawing leucocytes from donor sheep as previously described (Ross and Halliday, 1979a) and were administered by the combined intravenous and intraperitoneal routes. In the first investigation three groups of four 6-week-old Blackface lambs were used.…”

Section: Methodsmentioning

confidence: 99%

“…Previous investigations have demonstrated the ability of TF prepared from sheep infected with three abomasal Trichostrongylids to transfer resistance to challenge infection in recipient sheep, both between sheep of different breeds and between sheep of the same breed and different ages Halliday, 1978, 1979a andb;Ross et al, 1979)o Initially, experiments were carried out using non-dialysed TF preparations but latterly similar transfers of resistance were achieved with dialysed preparations (Ross and Halliday, 1979a). These earlier studies demonstrated the failure of TF prepared from parasite-free donors to transfer resistance to T. axei challenge when similarly prepared material from T. axei infected donor lambs successfully transferred resistance to challenge.…”

Section: Introductionmentioning

confidence: 96%

See 1 more Smart Citation

Passive transfer of immunity to Trichostrongyle species infections in sheep. Investigations of specificity and limitations of ‘transfer factor’ activity withTrichostrongylus axei infections

Ross¹,

Halliday²

1980

Vet Res Commun

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Passive transfer of immunity to Trichostrongyle species infections in sheep. Investigations of specificity and limitations of ‘transfer factor’ activity withTrichostrongylus axei infections

Ross¹,

Halliday²

1980

Vet Res Commun

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“…However, serum from sheep immunised against T. colubriformis has reduced the in vitro feeding and oviposition of the nematode (Bottjer et al 1985;Bone and Klesius 1986). Transfer of passive immunity via immune sheep or guinea-pig serum against T. colubriformis (Connan 1972;Ross and Halliday 1982) or immune sheep serum against T. axei (Ross and Halliday 1979) has also been demonstrated to induce protection against homologous challenge.…”

Section: Discussionmentioning

confidence: 99%

Drug-abbreviated infections of Trichostrongylus colubriformis and development of immunity in jirds (Meriones unguiculatus)

Ziam¹,

Pandey²,

Elegbe³

et al. 2000

Parasitol Res

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The objective of this study was to examine the development and the duration of immunity achieved with drug-abbreviated infections of Trichostrongylus colubriformis in jirds (Meriones unguiculatus). Jirds were primarily infected either by trickle infection with 6 x 100 infective larvae (L3) of T. colubriformis at 3-day intervals or by a single infection with 600 L3. On day 35 post-infection, one batch of jirds from each group was autopsied; the others were treated with oxfendazole at a dose of 5 mg/kg and were challenged with 1,000 L3 on either day 7 or day 42 post-treatment. All jirds were autopsied at 17 days post-challenge. Trickle infection resulted in lower levels of egg production during the primary infection period. The systemic IgM and IgG antibody response was significantly stronger in trickle- and single-infected groups as compared with the negative control group (P < 0.01-P < 0.05). Significantly higher levels of intestinal IgA were demonstrated in trickle- and single-infected groups than in the negative control group (P < 0.01). Numbers of mucosal mast cells increased following infection, but this was not dependent on the type of immunisation. After challenge the extent of worm reduction was greater in trickle-infected than in single-infected subgroups. The IgM and IgG response was significantly stronger in challenged subgroups as compared with negative control subgroups (P < 0.01). However, the IgG response was weaker in control challenged subgroups than in challenged subgroups (P < 0.01). There was a negative correlation between the IgG response and the worm burden after the second challenge (r = -0.73). The acquired immunity to T. colubriformis infection in jirds developed within 5 weeks of primary infection. The level of immunity was higher after trickle infection than after single infection. Furthermore, the immunity persisted for at least 6 weeks after oxfendazole treatment in the absence of a worm burden and larval intake, which is very similar to the situation in domestic ruminant hosts.

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Dialysable leukocyte extracts modify the course of experimental paracoccidioidomycosis in the Syrian hamster

et al. 1993

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The effect of dialysable leukocyte extracts (DLE) obtained from hamsters immunized with Paracoccidioides brasiliensis (immune DLE) and from non-immunized hamsters (non-immune DLE) was studied in hamsters inoculated with P. brasiliensis by the intratesticular route. Treatment with immune or non-immune DLE was started during the third week of infection and was repeated at 7, 11, 15 and 19 weeks. A group of untreated infected animals was used as control. Animals were submitted to the delayed hypersensitivity skin test to P. brasiliensis antigen (PbAg) in vivo and assayed in vitro by the macrophage migration inhibition test in the presence of Phytohemagglutinin (PHA) and PbAg and by immunodiffusion for specific antibody. The animals were sacrificed at 4, 8, 12, 16 and 20 weeks. The morphology and extension of the lesions were studied at the inoculation site, and in lymph nodes, lungs, liver, spleen and kidneys. In contrast to the controls, animals treated with both DLEs maintained a positive cell-mediated immune response throughout the experiment and developed less extensive infection with a significantly lower number of fungi in the lesions. The results suggest that immune and non-immune DLE preparations modified the evolution of experimental paracoccidioidomycosis with equal efficiency. This similarity may be explained by the immunoregulatory activities of both extracts.

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Investigations of ‘transfer factor’ activity in immunity to Ostertagia circumcincta and Trichostrongylus colubriformis infections in sheep

Cited by 9 publications

References 10 publications

Passive transfer of immunity to Trichostrongyle species infections in sheep. Investigations of specificity and limitations of ‘transfer factor’ activity withTrichostrongylus axei infections

Passive transfer of immunity to Trichostrongyle species infections in sheep. Investigations of specificity and limitations of ‘transfer factor’ activity withTrichostrongylus axei infections

Drug-abbreviated infections of Trichostrongylus colubriformis and development of immunity in jirds (Meriones unguiculatus)

Dialysable leukocyte extracts modify the course of experimental paracoccidioidomycosis in the Syrian hamster

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