Investigations of Oxidant/antioxidant Status and Hemoglobin Biophysical Properties in Buffalo Calves with Special Reference to Inferior Preweaning Vitality

Ahmed, Waseem; Nabil, Ghada M.

doi:10.3923/pjbs.2007.2353.2358

Cited by 6 publications

(6 citation statements)

References 17 publications

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“…This study results was in agreement with Ahmed and Ghada (2007) who proved that the real cause of ill-thriftiness in buffalo calves was trace elements deficiency including Cu, Zn, Se and Fe and there is a tight relationship between antioxidant status and state of inferior vitality in buffalo calves as there was elevation of oxidative stress markers ' malondialdehyde (MDA)' and significant reduction in TAC.…”

Section: Discussionsupporting

confidence: 91%

Trace Elements Status and Antioxidants Profile in Ill-thrift Buffalo Calves

Ismael¹,

El-Sayed²,

Metwally³

et al. 2015

AJVS

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The goal of the present study was to evaluate some trace element concentrations and the activity of antioxidant systems in ill-thrift calves. A total number of (52) buffalo-calf was subjected to study. Out of them, (37) buffalo-calves had poor coat, poor general body condition score which constituted the ill-thrift group. The remained animals (15) were clinically healthy and kept as control group. Complete blood picture, trace elements profile, serum calcium, phosphorus & magnesium , blood urea nitrogen (BUN) , creatinine, some liver function parameters and total antioxidants capacity were evaluated. Results showed a significant reduction in the blood serum concentration of copper, cobalt, iron, selenium and zinc associated with normocytic normochromic anemia. Also a significant reduction in the activity of total antioxidants value was evident in ill-thrift calves. While levels of serum calcium, phosphorus and magnesium , blood urea nitrogen, creatinine and liver function parameters showed non-significant changes. In conclusion, a state of sub-optimal growth (ill-thrift) in buffalo-calves was largely attributed to trace element deficiency, in particular copper, cobalt, iron, selenium and zinc deficiency that may cause reduction in the total antioxidant capacity, with a lower ability to reduce oxidative compounds.

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Section: Discussionsupporting

confidence: 91%

Trace Elements Status and Antioxidants Profile in Ill-thrift Buffalo Calves

Ismael¹,

El-Sayed²,

Metwally³

et al. 2015

AJVS

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“…Selenium deficiency may result in a compromised immune function and suboptimal growth in small ruminants [54]. The pronounced decrease in Cu, Se, and Fe serum levels observed in the emaciated group in this study aligns with Ahmed et al's [55] findings indicating a deficiency in these trace elements can hinder goat growth. In the present study, Zn and Co showed insignificant changes in their levels in the emaciated group despite the established association between Zn and Co with the occurrence of ill-thrift in calves [8,11].…”

Section: Discussionsupporting

confidence: 89%

Clinical, Haematological, Biochemical Alterations, and Potential Risk Factors Associated with Ill-Thrift in Goats Raised at Smallholder Farms in Egypt

Esraa,

Safaa,

Samia

et al. 2025

Egyptian Journal of Veterinary Sciences

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LL-THRIFT or poor growth in small ruminants is a global concern for both veterinarians and small ruminants' producers. The aim of this study was to assess the risk factors of ill-thrift and the associated clinicopathological changes. Smallholder farms were the source of 150 goats used in the study. Based on clinical findings and body condition score (BCS), the goats were classified into 3 groups: emaciated (BCS 1, n = 46), thin (BCS 1.5-2, n = 52), and control (BCS≥2.5, n = 52), respectively. Blood samples were used for clinicopathological investigations, and risk factors were tested. Goats suffering from emaciation had a significant decrease in haemoglobin (HGB) (P= 0.012), mean corpuscular haemoglobin (MCH) (P= 0.029), mean corpuscular haemoglobin concentration (MCHC) (P=0.03), albumin (P=0.009), sodium (Na) (P=0.039), iron (Fe) (P=0.004), copper (Cu) (P=0.022), and selenium (Se) (P= 0.027) compared to the control group. White blood cell count and globulin levels, on the other hand, were significantly elevated in the emaciated group (P= 0.0001, and P= 0.039, respectively). Goats aged ≤ 2 years (odds ratio (OR): 6.5, P = 0.0001), female goats (OR: 10.1, P = 0.0001), and those fed on unbalanced rations (OR: 13.3, P = 0.032) were at higher risk of illthrift. In conclusion, this study evidenced that ill-thrift is associated with significant alterations in the haematological and biochemical profiles. Young age, gender, and unbalanced rations are the potential risk factors for ill-thrift in goats. Recognition of risk factors associated with ill-thrift provides valuable insights for prevention and management programs.

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“…Antioxidant parameters assessment. Assessment of Superoxide dismutase (SOD), catalase (CAT), lipid peroxidation and reduced glutathione (GSH) activities were estimated in serum and tissue homogenate according to Ahmed and Nabil (2007) (Ahmed and Nabil, 2007).…”

Section: Animal Studymentioning

confidence: 99%

Neuroprotective activity of Ulmus pumila L. in Alzheimer's disease in rats; role of neurotrophic factors

Hussein

Afifi

Soliman

et al. 2020

Heliyon

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Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders which affects the hippocampus and cortical neurons leading to impairment of cognitive ability. Treatment of AD depends mainly on acetylcholinesterase inhibitors, however, a novel therapeutic approach is introduced based on the maintenance of neuronal viability and functionality exerted through neurotrophic factors. In the current study, Ulmus pumila L. leaves alcoholic extract was investigated for its neuroprotective activity in AlCl 3 -induced AD in rats. Rats were orally treated with AlCl 3 (17 mg/kg) for 4 weeks followed by U. pumila extract (150 mg/kg b.wt.) for another 6 weeks. Treatment of neuro-intoxicated rats with U. pumila extract resulted in a significant regulation in neurotrophic factors; brain derived neurotrophic factor and transforming growth factor-β and pro-inflammatory cytokine; TNF. It also induced an elevation in serum levels of monoamine neurotransmitters; norepinephrine, dopamine and serotonin and a decline in brain acetlycholinesterase activity. U. pumila extract also showed potent antioxidant activity as indicated by the declined malondialdehyde and elevated reduced glutathione, catalase and super oxide dismutase levels in AD rats‘ brains. Histological improvement was detected in the cerebral cortex, the hippocampus and striatum of the treated rats . The phytochemical analysis of U. pumila extract revealed high contents of flavonoids and phenolics and the major compounds were isolated and chemically characterized. Additionally, U. pumila extract and the isolated compounds exerted a prominent activity in in-vitro acetylcholinesterase inhibition assay with kaempferol-3-O-β-glucoside being the most potent compound showing IC 50 of 29.03 ± 0.0155 μM. A molecular docking study indicated high affinity of kaempferol-3-O-β-robinobioside on acetylcholine esterase binding site with estimated binding free energy of –8.26 kcal/mol.

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Investigations of Oxidant/antioxidant Status and Hemoglobin Biophysical Properties in Buffalo Calves with Special Reference to Inferior Preweaning Vitality

Cited by 6 publications

References 17 publications

Trace Elements Status and Antioxidants Profile in Ill-thrift Buffalo Calves

Trace Elements Status and Antioxidants Profile in Ill-thrift Buffalo Calves

Clinical, Haematological, Biochemical Alterations, and Potential Risk Factors Associated with Ill-Thrift in Goats Raised at Smallholder Farms in Egypt

Neuroprotective activity of Ulmus pumila L. in Alzheimer's disease in rats; role of neurotrophic factors

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