Investigations of motor-cortex cortical plasticity following facilitatory and inhibitory transcranial theta-burst stimulation in schizophrenia: A proof-of-concept study

Hasan, Alkomiet; Brinkmann, Caroline; Strube, Wolfgang; Palm, Ulrich; Malchow, Berend; Rothwell, John C.; Falkai, Peter; Wobrock, Thomas

doi:10.1016/j.jpsychires.2014.12.006

Cited by 16 publications

(19 citation statements)

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Section: Non-invasive Brain Stimulationmentioning

confidence: 99%

“…A proof-of-concept study investigated TBS-induced LTP and LTD-like plasticity in the left primary motor cortex of 10 SCZ patients and 10 healthy controls ( 60 ). In healthy subjects cTBS300 and cTBS600 induce LTP- and LTD-like cortical excitability changes in the motor cortex ( 58 – 60 , 63 ). The duration of the stimulation protocol determines the direction of cortical plasticity changes; cTBS300 delivers high frequency stimulation in a continuous train lasting 20 s, whereas cTBS600 lasts 40 s ( 60 ).…”

Section: Non-invasive Brain Stimulationmentioning

confidence: 99%

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A Review of Impaired Neuroplasticity in Schizophrenia Investigated with Non-invasive Brain Stimulation

et al. 2016

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BackgroundSeveral lines of evidence implicate dysfunctional neuronal plasticity in the pathophysiology of schizophrenia (SCZ). Aberrant glutamatergic and gamma amino-butyric acid neurotransmission are thought to underlie core cognitive deficits and negative symptoms of SCZ. Non-invasive brain stimulation (NIBS) allows for the in vivo study of cortical plasticity and excitability at the systems level of the human motor cortex. This review will focus on summarizing the available neurophysiological evidence for impaired motor cortical plasticity in SCZ assessed by NIBS.MethodsA search of MEDLINE, Embase, and PubMed was performed on the use of NIBS techniques to investigate neuroplasticity in the motor cortex of SCZ patients. The relevant articles were summarized.ConclusionOur review of the literature reveals evidence for disrupted neuroplasticity in SCZ and its close association to alterations in cortical inhibition and dysfunctional intracortical connectivity. Further investigations are required to elucidate the neurobiological mechanisms that underlie dysfunctional plasticity in SCZ in order to develop more targeted therapeutic interventions for SCZ patients.

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Section: Non-invasive Brain Stimulationmentioning

confidence: 99%

Section: Non-invasive Brain Stimulationmentioning

confidence: 99%

A Review of Impaired Neuroplasticity in Schizophrenia Investigated with Non-invasive Brain Stimulation

et al. 2016

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“…Potential factors that may infl uence motor-cortex plasticity in schizophrenia could be the medication status , the smoking status , the genetic status or the stage of the disorder . Further studies are needed to explore whether schizophrenia patients have a general inability to develop motor-cortical plasticity or whether just the likelihood to develop an expected response compared to healthy controls is reduced (Hasan et al 2015). An extension of these fi ndings to the DLPFC is urgently needed in the future to better explore the impact of plasticity defi cits on schizophrenia symptomatology.…”

Section: Cortical Plasticitymentioning

confidence: 99%

Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia part I: Neurophysiology

Thibaut

Boutros

Jarema

et al. 2015

The World Journal of Biological Psychiatry

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The neurophysiological components that have been proposed as biomarkers or as endophenotypes for schizophrenia can be measured through electroencephalography (EEG) and magnetoencephalography (MEG), transcranial magnetic stimulation (TMS), polysomnography (PSG), registration of event-related potentials (ERPs), assessment of smooth pursuit eye movements (SPEM) and antisaccade paradigms. Most of them demonstrate deficits in schizophrenia, show at least moderate stability over time and do not depend on clinical status, which means that they fulfil the criteria as valid endophenotypes for genetic studies. Deficits in cortical inhibition and plasticity measured using non-invasive brain stimulation techniques seem promising markers of outcome and prognosis. However the utility of these markers as biomarkers for predicting conversion to psychosis, response to treatments, or for tracking disease progression needs to be further studied.

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“…Psychiatric disorders such as depression and schizophrenia typically arise in late adolescence (5–8) and are associated with disrupted long-term potentiation (LTP) (9–11). LTP is a form of neuroplasticity that occurs when co-firing neurons become increasingly associated over time (12).…”

Section: Introductionmentioning

confidence: 99%

Paired-Associative Stimulation-Induced Long-term Potentiation-Like Motor Cortex Plasticity in Healthy Adolescents

et al. 2017

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ObjectiveThe objective of this study was to evaluate the feasibility of using paired-associative stimulation (PAS) to study excitatory and inhibitory plasticity in adolescents while examining variables that may moderate plasticity (such as sex and environment).MethodsWe recruited 34 healthy adolescents (aged 13–19, 13 males, 21 females). To evaluate excitatory plasticity, we compared mean motor-evoked potentials (MEPs) elicited by single-pulse transcranial magnetic stimulation (TMS) before and after PAS at 0, 15, and 30 min. To evaluate inhibitory plasticity, we evaluated the cortical silent period (CSP) elicited by single-pulse TMS in the contracted hand before and after PAS at 0, 15, and 30 min.ResultsAll participants completed PAS procedures. No adverse events occurred. PAS was well tolerated. PAS-induced significant increases in the ratio of post-PAS MEP to pre-PAS MEP amplitudes (p < 0.01) at all post-PAS intervals. Neither socioeconomic status nor sex was associated with post-PAS MEP changes. PAS induced significant CSP lengthening in males but not females.ConclusionPAS is a feasible, safe, and well-tolerated index of adolescent motor cortical plasticity. Gender may influence PAS-induced changes in cortical inhibition. PAS is safe and well tolerated by healthy adolescents and may be a novel tool with which to study adolescent neuroplasticity.

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Investigations of motor-cortex cortical plasticity following facilitatory and inhibitory transcranial theta-burst stimulation in schizophrenia: A proof-of-concept study

Cited by 16 publications

References 71 publications

A Review of Impaired Neuroplasticity in Schizophrenia Investigated with Non-invasive Brain Stimulation

A Review of Impaired Neuroplasticity in Schizophrenia Investigated with Non-invasive Brain Stimulation

Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia part I: Neurophysiology

Paired-Associative Stimulation-Induced Long-term Potentiation-Like Motor Cortex Plasticity in Healthy Adolescents

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