Investigations of mobile phase contributions to enantioselective anion- and zwitterion-exchange modes on quinine-based zwitterionic chiral stationary phases

Hoffmann, Christian V.; Reischl, Roland; Maier, Norbert M.; Lämmerhofer, Michael; Lindner, Wolfgang

doi:10.1016/j.chroma.2008.12.044

Cited by 71 publications

(85 citation statements)

References 28 publications

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“…MeCN-rich mobile phases [55,57] . The best column performance, which means short analysis time, high peak efficiency and enantioselectivity was usually obtained in zwitterionic and cation-exchange mode at MeOH/MeCN 50/50 (v/v) composition.…”

Section: Resultsmentioning

confidence: 99%

“…The opposite trend was found for pure enantioselective cation-exchanger-type CSPs, where the retention decreased, in the order TEA < DEA < EA < NH3, and base additive served as the counter-ions [50,57,84,85] .…”

Section: Figure 13 Effect Of Elution Strengths Of Co-and Counter-ionmentioning

confidence: 95%

“…They act as a competitor in the ion-exchange equilibrium. The addition of acid and base to the nonaqueous polar organic solvents greatly influences the solvation of both SO and SA, and the anions and cations of acid and base additives have great effects on the elution strength of the mobile phase, inversely acting as displacers at the cation-and anion-exchanger sites of the zwitterionic CSP, as summarized in Figure 13 [57,[84][85][86] . According to literature reports in single anion-exchange mode the base additives (co-ions)…”

Section: Effect Of the Nature Of Base And Acid Additivesmentioning

confidence: 99%

“…The investigations were extended by application of HO mobile phase, because solvation of the ionic compounds can play an important role in enantioseparations on ZWIX CSPs [57,82,83] . Water is on the top of the protic solvent list due to its powerful proton activity.…”

Section: Effect Of Thf Content In the Separation Of Trans-paroxetine mentioning

confidence: 99%

“…depicts the most important interactions between the SAs and zwitterionic SOs. The fusion of anion-exchange and cation-exchange moieties in ZWIX CSPs is a good choice to facilitate the enantiomer discrimination of chiral acids, amines, amino acids and peptides [56,57] .…”

Section: Cinchona Alkaloid-based Cspsmentioning

confidence: 99%

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Investigation of Novel Cinchona Alkaloid-based Zwitterionic Chiral Stationary Phases in Cation- and Zwitterion-Exchange Modes

Grecsó¹

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Section: Resultsmentioning

confidence: 99%

Section: Figure 13 Effect Of Elution Strengths Of Co-and Counter-ionmentioning

confidence: 95%

Section: Effect Of the Nature Of Base And Acid Additivesmentioning

confidence: 99%

Section: Effect Of Thf Content In the Separation Of Trans-paroxetine mentioning

confidence: 99%

Section: Cinchona Alkaloid-based Cspsmentioning

confidence: 99%

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Investigation of Novel Cinchona Alkaloid-based Zwitterionic Chiral Stationary Phases in Cation- and Zwitterion-Exchange Modes

Grecsó¹

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Chiral Stationary Phases Derived from Cinchona Alkaloids

Lämmerhofer

Lindner

2023

Chiral Separations and Stereochemical Elucidation

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Unusual Temperature‐Induced Retention Behavior of Constrained β‐Amino Acid Enantiomers on the Zwitterionic Chiral Stationary Phases ZWIX(+) and ZWIX(–)

et al. 2014

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The effects of temperature on the chiral recognition of cyclic β-amino acid enantiomers on zwitterionic [Chiralpak ZWIX(+) and ZWIX(-)] chiral stationary phases were investigated. Experiments were performed at different mobile phase compositions and under 10°C column temperature increments in the temperature range 10-50°C. Apparent thermodynamic parameters and T(iso) values were calculated from plots of ln k and ln α versus 1/T, respectively. Unusual temperature behavior was observed, especially on the ZWIX(-) column, where the application of MeOH/MeCN (50/50 v/v) containing 25 mM triethylamine and 50 mM formic acid as mobile phase led to nonlinear van't Hoff plots and increasing retention time with increasing temperature. On both columns, both enthalpically and entropically driven separations were observed.

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Investigations of mobile phase contributions to enantioselective anion- and zwitterion-exchange modes on quinine-based zwitterionic chiral stationary phases

Cited by 71 publications

References 28 publications

Investigation of Novel Cinchona Alkaloid-based Zwitterionic Chiral Stationary Phases in Cation- and Zwitterion-Exchange Modes

Investigation of Novel Cinchona Alkaloid-based Zwitterionic Chiral Stationary Phases in Cation- and Zwitterion-Exchange Modes

Chiral Stationary Phases Derived from Cinchona Alkaloids

Unusual Temperature‐Induced Retention Behavior of Constrained β‐Amino Acid Enantiomers on the Zwitterionic Chiral Stationary Phases ZWIX(+) and ZWIX(–)

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