Investigations of Hydrolytic Products of Butalbital

Occurrence and Fate of Barbiturates in the Aquatic Environment

“…Their metabolic pathway in human and animal organisms has been studied extensively, but very little is known about their biodegradability in the environment. Some studies dealt with abiotic degradation of barbiturates under various conditions such as hydrolysis at different temperatures and pH values ( , ). Depending on the substituent at the C5 position, the properties, and therefore the behavior and stability varies, e.g.…”

Practical Kinetics I: Quantitation of Barbiturate Stability by TLC

“…(2)(3)(4)(8)(9)(10)(11). These products are easily separated from the parent molecule by the thin-layer system used (5).…”

“…With some barbiturates, only the parent compound may be seen on fluorescent plates under short wavelength UV light. Other compounds may be observed using iodine vapor, followed by removal of the color on heating the TLC plates (2). Urea must be visualized in another manner (2).…”

“…Other compounds may be observed using iodine vapor, followed by removal of the color on heating the TLC plates (2). Urea must be visualized in another manner (2). The anionic form of the pyrimidine ring system is easily extractable from the TLC plates into 0.1 N NHIOH, which serves as a suitable solvent for many anionic substances.…”

Alkaline Hydrolysis of 1,3-Dimethylphenobarbital

“…The 5,5-disubstituted barbituric acid alkaline hydrolysis has recently received attention (1)(2)(3)(4)(5). The pyrimidine ring may cleave at the 1,6-position, yielding a malonuric acid, or at the 1,2-position, forming a carbamic acid.…”