Investigations of Fungal Secondary Metabolites with Potential Anticancer Activity

Baldé, E.S.; Andolfi, Anna; Bruyère, Céline; Cimmino, Alessio; Lamoral-Theys, Delphine; Vurro, Maurizio; Damme, Marc Van; Altomare, Claudio; Mathieu, Véronique; Kiss, Róbert; Evidente, Antonio

doi:10.1021/np900731p

Cited by 52 publications

(36 citation statements)

References 33 publications

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“…Secondary metabolites have a significant role to control various biological activities 15 . Likewise, it was also recognized that secondary-metabolite are effectively control the cancers and cancer related diseases 16,17 . The GC-MS analysis of methanol extract of P. guajava showed 08 different compounds.…”

Section: Discussionmentioning

confidence: 99%

The Phytochemical and Comparative Anticancer Study of Methanolic and Chloroform Extracts of Psidium guajava L. Leaves of Pakistani Origin

Abbas¹,

Ansari²,

Hassan³

et al. 2020

J. Drug Delivery Ther.

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The chief focus of our study is to evaluate the phytochemical and anti-cancer activity of methanol (PGM) and chloroform extracts (PGC) of the leaves of Psidium guajava (guava) collected from local area of district Sialkot, Pakistan. Shade dried milled leaves was subjected to extraction (maceration) with methanol and chloroform. Quantitative and qualitative screenings by GC-MS and phytochemical techniques were performed. Then different secondary metabolites and phytochemical compounds were identified which are typically associated with the existence of therapeutic characteristics. Psidium guajava has been extensively used as herbal remedies like, anti-diarrheal, antihypertensive, antibacterial, antifungal as well as to control obesity, ulcer, diabetes. In this study, both extracts of P. guajava were evaluated for their anticancer activities against HeLa cell-lines (cancerous cells). The healthiest anticancer response in the form of cell-line suppression was perceived with 200µg/mL of both extracts, PGM showed 81% and PGC exhibited 91% while the standard drug doxorubicin presented around 76% inhibition. The comparative better result was seen with chloroform extract than methanolic abstract. In conclusion, the chloroform and methanol extracts of our nominated plant from Pakistan origin has a good source of phytochemicals that revealed an outstanding anti-cancer potential. Keywords: Psidium guajava, anticancer, phytochemicals, methanol extracts, secondary metabolites.

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Section: Discussionmentioning

confidence: 99%

The Phytochemical and Comparative Anticancer Study of Methanolic and Chloroform Extracts of Psidium guajava L. Leaves of Pakistani Origin

Abbas¹,

Ansari²,

Hassan³

et al. 2020

J. Drug Delivery Ther.

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“…Previous in vitro studies demonstrated cytotoxicity of A. fumigatus CFs against macrophages 13, 15, human nasal epithelial 16 and human umbilical vein endothelial cells 17. Anticancer activity of A. fumigatus metabolites 18, 19 and cytotoxicity of its spore-borne metabolite to A549 tumor lung cell line were also shown 9.…”

Section: Introductionmentioning

confidence: 92%

In vitro Protease Inhibition and Cytotoxicity of Aspergillus fumigatus Biomolecules Secreted under Long-Term Aerated Conditions

Arsenijevic¹,

Pekmezović²,

Rajković

et al. 2014

Int. J. Med. Sci.

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The fatality rate of invasive aspergillosis (IA) is still very high, especially in prolonged and untreated pulmonary cases. Aspergillus fumigatus is the main causative agent of IA and investigation of its metabolites could provide valuable insight into virulence factor(s) associated with this organism. We evaluated the A. fumigatus culture filtrate (CF) products generated during short- and long-term aerated and non-aerated conditions and tested for (i) inhibition of cysteine or serine proteases and (ii) cytotoxicity. In addition, the mathematical model was determined using response surface methodology (RSM) to estimate the influence of different fermentation conditions on A. fumigatus CF characteristics, predict enzyme inhibition and make possible correlations with in vivo conditions. Biosynthesis of A. fumigatus low molecular weight proteinaceous products (from 6.4 to 15.4 kDa) was observed after 6 days of growth under aerated and alkaline conditions. Also, only these CFs showed significant reduction in cell lines survival (Caco-2 and WISH 35.6% and 54.6%, respectively). Obtained results provide solid starting point for further studies that would include: (i) detailed chemical characterization of A. fumigatus CF, (ii) activity relationships and in vivo correlation with pathogenicity of prolonged pulmonary IA and (iii) possible use of biomolecules as diagnostic or therapeutic markers.

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“…At a concentration of 25 μM, ergosterol peroxide (19) completely inhibits growth and induces apoptosis of HL-60 cells [50]. It also suppresses inflammatory responses in RAW 264.7 macrophages and the growth of HT29 colon adenocarcinoma cells [51], and it has inhibitory effects on human MCF-7 breast adenocarcinoma cells by inducing cell apoptosis [52].…”

Section: Volatile and Nonvolatile Compoundsmentioning

confidence: 99%

“…Fig. 8 Chemical structure of ergosterol peroxide (19) isolated from a marine-derived strain of P. variotii…”

Section: Conflict Of Interestmentioning

confidence: 99%

The Chemical Diversity of the Ascomycete Fungus Paecilomyces variotii

Mioso

Marante

Laguna

2015

Appl Biochem Biotechnol

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Paecilomyces variotii isolated from a broad range of habitats drives the diversification of new high-value-added secondary metabolites that could potentially play an important role in human and animal health. These metabolites include the anhydride metabolite of the nonadride family, as well as the following compounds: naphthopyranone metabolites, sphingofungins, eicosenoic acids, new branched fatty acids, ascofuranone, polyketides, an anacardic acid analogue, straight-chain peptides, and volatile compounds. These natural products show that P. variotii can provide leading compounds for new drug discoveries, which may include herbicide agents, some of which are important in the agrochemical market. Finally, this review outlines recent developments, trends, and prospects for the chemistry of this ascomycete.

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Investigations of Fungal Secondary Metabolites with Potential Anticancer Activity

Cited by 52 publications

References 33 publications

The Phytochemical and Comparative Anticancer Study of Methanolic and Chloroform Extracts of Psidium guajava L. Leaves of Pakistani Origin

The Phytochemical and Comparative Anticancer Study of Methanolic and Chloroform Extracts of Psidium guajava L. Leaves of Pakistani Origin

In vitro Protease Inhibition and Cytotoxicity of Aspergillus fumigatus Biomolecules Secreted under Long-Term Aerated Conditions

The Chemical Diversity of the Ascomycete Fungus Paecilomyces variotii

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